A facile and an efficient protocol has been developed for the synthesis of novel 1,2,3‐triazole substituted 4
H
‐chromene derivatives
4
in single pot by multicomponent reaction of ...1,3‐cyclohexanedione, malononitrile and 1‐substituted 1,2,3‐triazole‐5‐aldehyde using potassium carbonate as catalyst.
A series of novel positional isomers of 1-alkyl-2-trifluoromethyl benzimidazole derivatives
3a
–
j
and
4a
–
j
have been synthesized and screened for antibacterial activity against gram positive ...bacteria viz,
Bacillus subtilis
,
Staphylococcus aureus
and gram negative bacteria viz.,
Escherichia coli
,
Pseudomonas aeruginosa
and antifungal activity against
Candida albicans
,
Aspergillus niger
,
Rhizopus oryzae
and
Saccharomyces cerevisiae
. Results indicate that compounds
3b
,
4b
were having promising antibacterial and antifungal activity.
7-Trifluoromethyl-4-hydroxy quinoline-3-carboxylic acid ethyl ester was prepared from 3-amino benzotrifluoride and EMME. The hydroxyquinoline was reacted with amino acids to furnish amino acid ...funtionalised quinolines (
5
,
6
,
7
). The compounds were alkylated by ethyl iodide followed by hydrolysis afforded the title compounds in good yields. They were screened for their antibacterial activity for in vitro against Gram +ve and Gram −ve bacterial strains and found
11e
and
11b
as promising compounds.
The condensation of trifluoromethyl -o-phenylenediamines and aromatic aldehydes under microwave irradiation on metal halide supported alumina resulted exclusively trifluoromethyl-2-aryl ...benzimidazoles.
*IICT Communication No. 4776.
Novel pyrido2,3-dpyrimidines (2,4) were synthesized by reacting 2-amino-3-cyano-4-trifluoromethyl-6-substituted pyridines (1) with Grignard reagent followed by condensation with ...anhydride/chloroacetylchloride/aromatic aldehyde.
a
IICT Communication No.: 040104.
Synthesis of novel-2,3-bifunctionalised indole regioisomers (
2
/
3
and
6
/
7
) from unsymmetrical dicyanoanilines
1
by regioselective cyclization in two independent ways. Regioisomers
6
are further ...utilized in synthesis of novel 4,5-dihydro1,3oxazino5,4-
b indole-6-carbonitriles
9
.
Graphical Abstract
Fluoro-substituted 3-cyano-2-methyl-benzo
bfurans and ethyl 2-methyl-benzo
bfuran-3-carboxylates are conveniently prepared in a single step in good yield by the microwave induced tandem ...intramolecular Wittig and Claisen rearrangement reactions of the corresponding (aryloxyacetyl) (cyano) methylene triphenylphosphorane and (aryloxyacetyl) (ethoxycarbonyl) methylene triphenylphosphoranes, respectively.
Graphical Abstract
Graphic
Unsymmetrical 1,2-phenylenediamine on reaction with various ketones resulted in a number of fluorinated heterocycles such as benzimidazoles, quinoxalines and spiro benzimidazoles in high ...yields. The role of substituents in diamine in its reaction with various ketones and on the nature of product formation has been studied in detail.
Exclusive formation of either 2- or 4-trifluoromethyl(1H,5)arylodiazepines
(5,7)
(6,8)
was observed in the condensation of 1,1,1-trifluoro-3-(isobutoxymethylene)-2-propanones
2
3
with ...o-arylenediamines
4 under microwave irradiation conditions. Thermal reactions under the same temperature and time produced no products. Orthoaminophenols
9 and o-aminothiophenol
12 with
2 and
3 under the same conditions produced the respective oxazepines
10,11 and thiazepines
13,14. The synthetic equvalent
1 gave similarly benzimidazoles
15, benzoxazoles
16 and benzthiazoles
17.
Graphic
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