In the last few decades, considerable progress has been made in anticancer agents development, and several new anticancer agents of natural and synthetic origin have been produced. Among heterocyclic ...compounds, thiazole, a 5-membered unique heterocyclic motif containing sulphur and nitrogen atoms, serves as an essential core scaffold in several medicinally important compounds. Thiazole nucleus is a fundamental part of some clinically applied anticancer drugs, such as dasatinib, dabrafenib, ixabepilone, patellamide A, and epothilone. Recently, thiazole-containing compounds have been successfully developed as possible inhibitors of several biological targets, including enzyme-linked receptor(s) located on the cell membrane, (i.e., polymerase inhibitors) and the cell cycle (i.e., microtubular inhibitors). Moreover, these compounds have been proven to exhibit high effectiveness, potent anticancer activity, and less toxicity. This review presents current research on thiazoles and elucidates their biological importance in anticancer drug discovery. The findings may aid researchers in the rational design of more potent and bio-target specific anticancer drug molecules.
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•Recent advances in thiazole containing compounds with anticancer properties.•Diverse biological targets and their potent inhibitors related to anticancer actions of thiazoles have been reviewed.•Several compounds reported to be cytotoxic against various cancer cell lines have been discussed.•Brief summary of recent patents and novel cyclic peptide antibiotics in cancer treatment has been provided.
In the present paper, we aim to define λ-statistical summability, Vλ-statistical summability in neutrosophic-2-normed spaces (briefly called N − 2 − NS) and study some relationships among these ...notions. We give an example that shows λ-statistical summability is stronger method in neutrosophic-2-normed spaces. Finally, we define λ-statistically Cauchy sequence and λ-statistically completeness in neutrosophic-2-normed spaces and obtain the Cauchy convergence criteria in these spaces.
In the present paper, we aim to define Sθ-summability in neutrosophic 2-normed spaces and study some of its properties. We provide examples that shows our method of summability is stronger in these ...spaces. Finally we introduce Sθ-Cauchy and Sθ-completeness and prove that every neutrosophic-2-normed spaces is Sθ-complete.
The imidazole nucleus is inimitable and ubiquitous and it is very well known to play an important role in living organisms. Imidazole derivatives are under intensive scientific exploration due to ...their diverse and significant pharmacological activities.
The present paper is an attempt to discuss chemistry, synthetic aspects including click chemistry procedures of imidazoles through systematic literature survey.
Biological activity profiles of the imidazole derivatives reported in recent scientific literature from 2000 to 2015 have been discussed in detail. It has been found that imidazole derivatives depict appreciable antiinfective activity potential.
It is anticipated that the information compiled in this paper will be useful and motivating to prospective researchers working on this heterocylic scaffold.
The composition of the extracellular matrix (ECM) in nervous tissue plays an important role in controlling neuronal outgrowth and synapse development. Changes in both protein and glycosaminoglycan ...components of the ECM occur with tissue injury and may affect neuron growth. To investigate neuron responses to alterations in fibronectin (FN), a major component of the wound ECM, we grew cortical neurons on cell-derived decellularized matrices composed of wild type FN (FN
) or of a mutant form of FN (FN
) from which the III
heparin-binding site had been deleted by CRISPR-Cas 9 gene editing. The most significant effect of the mutant FN was a reduction in dendrite outgrowth. Not only were dendrites shorter on mutant FN
-collagen (COL) matrix than on wild type (FN
-COL) matrix, but the number of dendrites and dendritic spines per neuron and the spine densities were also dramatically reduced on FN
-COL matrices. Mass spectrometry and immunostaining identified a reduction in tenascin-C (TN-C) levels in the mutant matrix. TN-C is an ECM protein that binds to the III
site of FN and modulates cell-matrix interactions and has been linked to dendrite development. We propose that TN-C binding to FN in the wound matrix supports dendrite and spine development during repair of damaged neural tissue. Overall, these results show that changes in ECM composition can dramatically affect elaboration of neurites and support the idea that the ECM microenvironment controls neuron morphology and connectivity.
In this current paper, our objective is to establish neutrosophic n-normed linear space and introduce the convergence structure within these spaces. We also define Cauchy sequences, and obtained the ...relations between these notions.
In present paper, we aim to define λ-statistical convergence, λ-statistical Cauchy and λ-statistical completeness of sequences in neutrosophic soft normed linear spaces (briefly called NSNLS). We ...study certain properties of these notions and provide example to show that λ-statistical convergence is a more general method of summability in these spaces.
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