Drive bearings, as essential components of vehicles, play a crucial role in ensuring the safety and reliability of intelligent transportation systems. By monitoring and analyzing the operating ...condition of drive bearings, it is possible to troubleshoot the transmission system and improve the service life of the vehicle. However, due to the complexity of monitoring devices, noise interference, and the correlation between data features, traditional feature extraction methods often difficult to obtain satisfactory diagnostic results. To address this issue, this study proposes a novel adaptive feature fusion and selection method for vehicle fault diagnosis systems. First, the CNN-Transformer-LSTM backbone network is used to simultaneously extract local and global features to fully capture the complex patterns and dynamic changes in the data. Secondly, by introducing a self-attention mechanism, the importance of each feature is adaptively adjusted to highlight key information in the complex feature space. Finally, combined with the improved group LASSO technology, redundant features are effectively removed and the accuracy of feature selection is further improved. Extensive experimental results demonstrate that the proposed method outperforms other competing methods in terms of diagnostic accuracy, achieving prediction accuracy up to 99%.
Patients with hematologic disorders may experience anxiety and depression due to their immunocompromised status and potential side effects of therapies. Healthy lifestyle behaviors might enhance the ...mental health. To evaluate the association of both separate and clustering pattern lifestyle behaviors with anxiety and depression in hematological patients, healthcare providers can develop future initiatives that respond to the specific needs of this population. A total of 185 patients with hematologic disorders were enrolled in this cross-sectional study. Linear regression analysis was performed to measure the association of separate lifestyles with anxiety and depression. Latent class analysis was further conducted to identify homogeneous and mutually exclusive lifestyle classes, and the logistic regression was then used to assess the relationship between class memberships and symptoms of anxiety and depression. The study found sleep quality was correlated with anxiety and depression. Nevertheless, no association of anxious and depressive symptoms with sitting and exercise, dietary habits, toxicant exposure, drinking, and smoking, in either the overall patient population or patients classified by hematologic neoplasms. Two latent classes of lifestyle behaviors were further identified, but the class memberships were independent of anxiety and depression. The study suggested that promoting sleep quality was a viable intervention for patients with hematologic disorders. However, the clustering pattern of lifestyles may not be a reliable indicator of psychological issues.
Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease is difficult to diagnose, treat ...and control. We present a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 genes. Comparisons with the genome sequences from other taxa show that E. granulosus has acquired a spectrum of genes, including the EgAgB family, whose products are secreted by the parasite to interact and redirect host immune responses. We also find that genes in bile salt pathways may control the bidirectional development of E. granulosus, and sequence differences in the calcium channel subunit EgCavβ1 may be associated with praziquantel sensitivity. Our study offers insights into host interaction, nutrient acquisition, strobilization, reproduction, immune evasion and maturation in the parasite and provides a platform to facilitate the development of new, effective treatments and interventions for echinococcosis control.
Bluetongue virus (BTV) is the ‘type’ species of the genus Orbivirus causing bluetongue (BT) in sheep, bovine and other ruminants. Twenty‐four serotypes and several atypical serotypes of BTV were ...identified worldwide. In present study, a novel strain of BTV (V196/XJ/2014) was isolated from an asymptomatic sentinel goat in Yuli County, Xinjiang of China. Serotype identification of this isolate exhibited uniform negative results by serotype‐specific conventional RT‐PCR and real‐time RT‐PCR for BTV‐1 to BTV‐27, and virus neutralization tests using reference sera of BTV‐1 to BTV‐24. Genomic analysis showed V196/XJ/2014 grouped with atypical serotypes of BTV‐25 to BTV‐28, BTV‐X/XJ1407, BTV‐X/ITL2015 and BTV‐Y/TUN2017, while segment 2 and VP2 protein of V196/XJ/2014 shared <63.4%/61.4% nucleic acids and amino acids sequence identities with other recognized BTV serotypes and its segment 2 formed a separate ‘nucleotype’ in phylogenetic tree. These results indicated V196/XJ/2014 does not belong to any reported serotypes of BTV. Further studies of infectivity and pathogenicity showed that goats infected with V196/XJ/2014 did not exhibit observed clinical symptoms, but high level of virus amplification and homologous neutralization antibodies were detected post‐infection. Our studies suggested a novel putative serotype of BTV‐29 was isolated in Xinjiang of China, which expands our knowledge about the diversity of BTV.
Aim
This study aimed to explore the level and influencing factors of fatigue in patients with rheumatoid arthritis.
Methods
This cross‐sectional study was conducted in 243 patients with rheumatoid ...arthritis from April 2016 to March 2017. The Bristol Rheumatoid Arthritis Fatigue Multi‐Dimensional Questionnaire, Arthritis Self‐Efficacy Scale‐8, Visual Analogue Scale for pain, physical function subscale of Short Form 36‐Item Health Survey, Hospital Anxiety and Depression Scale, Perceived Social Support Scale, Pittsburgh Sleep Quality Index and a self‐designed demographic and disease‐related information questionnaire were used to collect the data. Stepwise linear multiple regression was used to clarify the impact of statistically significant variables (P < 0.05) in the independent sample t test, one‐way ANOVA and correlation analysis on the level of fatigue.
Results
Stepwise linear multiple regression analyses showed that disease activity, self‐efficacy, physical function, pain, depression, duration of morning stiffness and anxiety were major factors influencing fatigue in patients with rheumatoid arthritis, which explained 59.5% of the total variance.
Conclusion
Our study demonstrated a moderate level of fatigue in Chinese patients with rheumatoid arthritis. In clinical practice, nurses should explore individualized intervention programmes based on related predictors of fatigue to help patients relieve fatigue.
Summary statement
What is already known about this topic?
Fatigue is a common problem in patients with rheumatoid arthritis (RA).
Little research has investigated what factors are associated with fatigue in patients with RA.
Nurses need to understand the factors that potentially influence fatigue in patients with RA, in order to improve the quality of life.
What this paper adds?
Fatigue is moderate in Chinese patients with RA, which is lower than the results of western countries.
Disease activity, self‐efficacy, physical function, pain, depression, duration of morning stiffness and anxiety are important factors affecting fatigue in patients with RA.
The implications of this paper:
Special attention should be paid to the RA patients with high level of fatigue.
The findings of this study highlight the need to develop effective strategies to alleviate fatigue and eventually improve the quality of life in patients with RA.
MicroRNAs (miRNAs) are important post-transcriptional regulators which control growth and development in eukaryotes. The cestode Echinococcus granulosus has a complex life-cycle involving different ...development stages but the mechanisms underpinning this development, including the involvement of miRNAs, remain unknown.
Using Illumina next generation sequencing technology, we sequenced at the genome-wide level three small RNA populations from the adult, protoscolex and cyst membrane of E. granulosus. A total of 94 pre-miRNA candidates (coding 91 mature miRNAs and 39 miRNA stars) were in silico predicted. Through comparison of expression profiles, we found 42 mature miRNAs and 23 miRNA stars expressed with different patterns in the three life stages examined. Furthermore, considering both the previously reported and newly predicted miRNAs, 25 conserved miRNAs families were identified in the E. granulosus genome. Comparing the presence or absence of these miRNA families with the free-living Schmidtea mediterranea, we found 13 conserved miRNAs are lost in E. granulosus, most of which are tissue-specific and involved in the development of ciliated cells, the gut and sensory organs. Finally, GO enrichment analysis of the differentially expressed miRNAs and their potential targets indicated that they may be involved in bi-directional development, nutrient metabolism and nervous system development in E. granulosus.
This study has, for the first time, provided a comprehensive description of the different expression patterns of miRNAs in three distinct life cycle stages of E. granulosus. The analysis supports earlier suggestions that the loss of miRNAs in the Platyhelminths might be related to morphological simplification. These results may help in the exploration of the mechanism of interaction between this parasitic worm and its definitive and intermediate hosts, providing information that can be used to develop new interventions and therapeutics for the control of cystic echinococcosis.
Hydatid disease caused by tapeworm is an increasing public health and socioeconomic concern. In order to enhance the therapeutic efficacy of praziquantel (PZQ) against tapeworm, PZQ-loaded ...hydrogenated castor oil solid lipid nanoparticle (PZQ-HCO-SLN) suspension was prepared by a hot homogenization and ultrasonication method. The stability of the suspension at 4°C and room temperature was evaluated by the physicochemical characteristics of the nanoparticles and in-vitro release pattern of the suspension. Pharmacokinetics was studied after subcutaneous administration of the suspension in dogs. The therapeutic effect of the novel formulation was evaluated in dogs naturally infected with Echinococcus granulosus. The results showed that the drug recovery of the suspension was 97.59% ± 7.56%. Nanoparticle diameter, polydispersivity index, and zeta potential were 263.00 ± 11.15 nm, 0.34 ± 0.06, and -11.57 ± 1.12 mV, respectively and showed no significant changes after 4 months of storage at both 4°C and room temperature. The stored suspensions displayed similar in-vitro release patterns as that of the newly prepared one. SLNs increased the bioavailability of PZQ 5.67-fold and extended the mean residence time of the drug from 56.71 to 280.38 hours. Single subcutaneous administration of PZQ-HCO-SLN suspension obtained enhanced therapeutic efficacy against tapeworm in infected dogs. At the dose of 5 mg/kg, the stool-ova reduction and negative conversion rates and tapeworm removal rate of the suspension were 100%, while the native PZQ were 91.55%, 87.5%, and 66.7%. When the dose reduced to 0.5 mg/kg, the native drug showed no effect, but the suspension still got the same therapeutic efficacy as that of the 5 mg/kg native PZQ. These results demonstrate that the PZQ-HCO-SLN suspension is a promising formulation to enhance the therapeutic efficacy of PZQ.
According to the Code for Seismic Design of Buildings （GB50011-2001）, ten typical reinforced concrete （RC） frame structures, used as school classroom buildings, are designed with different seismic ...fortification intensities （SFIs） （SFI=6 to 8.5） and different seismic design categories （SDCs） （SDC=B and C）. The collapse resistance of the frames with SDC=B and C in terms of collapse fragility curves are quantitatively evaluated and compared via incremental dynamic analysis （IDA）. The results show that the collapse resistance of structures should be evaluated based on both the absolute seismic resistance and the corresponding design seismic intensity. For the frames with SFI from 6 to 7.5, because they have relatively low absolute seismic resistance, their collapse resistance is insufficient even when their corresponding SDCs are upgraded from B to C. Thus, further measures are needed to enhance these structures, and some suggestions are proposed.
The radiation performance of acoustically actuated magnetoelectric (ME) antennas is originated from converse magnetoelectric (CME) effect that converts the electric field to magnetic field due to ...strain coupling. This paper presents a two-dimensional model for the CME effect of ME antennas with considering a fully magneto-elastic coupled characteristic of magnetostrictive materials. The nonlinear magnetostrictive relation is equivalent to a linear-like form using the equivalent parameter method. The coupled effects of magnetic bias and pre-stress on the CME coupling are discussed. The prediction for the CME coefficient shows a good agreement with the experimental data. The results indicate that pre-stress and magnetic bias have a strong-coupled effect on the CME effect. In addition, optimal loading modes are obtained for improving the CME effect. The radiations of ME antennas have not yet been obtained. Nevertheless, the results in this work may provide a basis for further investigation on the radiations.
•A two-dimensional multi-field coupling model for the CME effect is proposed.•The linear-like magnetostrictive relation is derived using equivalent parameters.•The coupled effect of magnetic bias and pre-stress is discussed in detail.•The influence of the loading directions of the external stimuli is analyzed.
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