This study navigates the digital transformation challenges within music education at higher vocational colleges and universities, proposing an innovative approach that integrates modern technology to ...enhance student musicality. Employing a mixed-methods research framework that combines quantitative and qualitative analyses, we explore the impact of digital teaching tools, including artificial intelligence and multimedia resources, on students’ musical understanding and creativity. Our findings reveal that students engaged with our digital-enhanced educational model exhibit significant improvements in rhythmic sense (30% increase) and creativity (25% increase) compared to traditional settings. This synergy of music education and technology elevates teaching outcomes and fosters innovative thinking among students, suggesting new directions for the evolution of music education in higher education institutions.
Precision studies at electron–positron colliders with centre-of-mass energies in the charm–tau region and below have strongly contributed to our understanding of light-meson interactions at low ...energies. We focus on the processes involving two or three light mesons with invariant masses below nucleon–antinucleon threshold. A prominent role is given to the interactions of the nine lightest pseudoscalar mesons (pions, kaons, η, and η′) and the two narrow neutral isoscalar vector mesons ω and ϕ. Experimental methods used to produce the mesons are reviewed as well as theory tools to extract properties of the meson–meson interactions. Examples of recent results from the DAΦNE, BEPCII, and VEPP-2000 colliders are presented. In the outlook we briefly discuss prospects for further studies at future super-charm–tau factories.
•The effect of limited oxygen daily supplied on the AD of corn straw was studied.•Daily oxygen supplied could obviously improve the AD performance of corn straw.•Specific methanogenic activity under ...microaerobic condition improved slightly.•The microbial community structure shift could explain the better AD performance.
Conventionally, oxygen is considered as inhibit factor of anaerobic digestion (AD). However, recent studies have demonstrated that AD performance could be enhanced by introducing limited amounts of oxygen (or air) directly into the anaerobic digester or during pretreatment step. In this study, impacts of microaeration on the anaerobic digestion of corn straw and the microbial community structure were investigated. Results showed that limited air introduced into fermentation system could improve the methane yield of corn straw. Maximum cumulative methane yield of 216.8ml/g VSsubstrate and maximum VS removal efficiency of 54.3% were simultaneously obtained under microaerobic condition with the air load of 12.5ml/LR per day, which were 16.5% and 10.3% higher than those of sample under anaerobic condition, respectively. Compared to anaerobic condition, the relative abundances of phylum Firmicutes, class Clostridia and order Clostridiales, which associated with hydrolysis process of AD were raised under microaerobic condition. In addition, the relative abundances of oxytolerant Methanosarcina and Methanobacterium were both doubled under microaerobic condition. Accordingly, specific methanogenic activity (SMA) under microaerobic condition improved slightly. The microbial community shift might be the reason for improved AD performance under microaerobic condition.
Astrocytoma is the most common type of primary malignant brain tumor, with pretty lowly 5-year survival rate in patients. Although extended surgical removal of the tumor and postoperative ...chemotherapy/radiotherapy executed, still there is large recurrence rate, mainly because diffuse glioma tumor cells ubiquitously infiltrate into normal parenchyma. So it becomes a priority to hunt novel molecular and signaling pathway targets to suppress astrocyma progression. HSP10, an important member of Heat shock proteins (Hsps) family, classically works as molecular chaperone folding or degradating of target proteins. Evolutionarily, HSP10 is also reported to be involved in immunomodulation and tumor progression. Poly (ADP-ribose) polymerase (PARP), important in DNA repair, is one of the main cleavage targets of caspase. And cleaved PARP (c-PARP) can serve as a marker of cells undergoing apoptosis. So far, whether the expression of HSP10 or c-PARP is associated with clinicopathologic implication for astrocytoma has not been reported. Meanwhile, it is unclear about the relationship between HSP10 and cell apoptosis. The purpose of this research is to elucidate the association between the expression of HSP10 and c-PARP and clinicopathological characteristics of astrocytoma by immunohistochemistry. The results showed that positive percentage of high HSP10 expression in astrocytoma 42/103, 40.8%) was significantly higher than that in the non-tumor control brain tissues (8/43, 18.6%) (P = 0.01). While no apparent difference of high c-PARP expression existed between astrocytoma and non-tumor control brain tissues. Furthermore, elevated expression of HSP10 was negative related to low expression of c-PARP (r = -0.224, P = 0.023), indicating high expression of HSP10 in astrocytoma inhibited apoptosis process effectively. And overexpression of HSP10 was proved to be the independent poor prognostic factor for astrocytoma by multivariate analysis. Taken together, our results suggest that elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
Light meson physics at BESIII Fang, Shuang-shi
National science review,
11/2021, Letnik:
8, Številka:
11
Journal Article
Recenzirano
Odprti dostop
Abstract
Studies of light meson decays are important tools to perform precision tests of the effective field theories, determine transition form factors and test fundamental symmetries. With very ...high statistics data samples, the Beijing Spectrometer III (BESIII) experiment provides a unique laboratory for light meson studies and is contributing significantly to a variety of these investigations. A brief review of recent progress in light meson decay studied at the BESIII experiment, including detailed studies of common decay dynamics, searches for rare/forbidden decays and new particles, is presented. Finally, together with descriptions of different experimental techniques, prospects for future studies of light mesons are discussed in some detail.
Studies of light mesons continue to provide opportunities for exploring a variety of physics at low energy scales. The BESIII experiment will bring the study of light meson decays into a precision era and make significant contributions to understanding of hadron physics in the non-perturbative regime.
A strictly anaerobic, mesophilic, carbohydrate-fermenting, hydrogen-producing bacterium, designated strain RL-CT, was isolated from a reed swamp in China. Cells were Gram-stain-negative, ...catalase-negative, non-spore-forming, non-motile rods measuring 0.7–1.0 µm in width and 3.0–8.0 µm in length. The optimum temperature for growth of strain RL-CT was 37 °C (range 25–40 °C) and pH 7.0–7.5 (range pH 5.7–8.0). The strain could grow fermentatively on yeast extract, tryptone, arabinose, glucose, galactose, mannose, maltose, lactose, glycogen, pectin and starch. The main end products of glucose fermentation were acetate, H2 and CO2. Organic acids, alcohols and amino acids were not utilized for growth. Yeast extract was not required for growth; however, it stimulated growth slightly. Nitrate, sulfate, sulfite, thiosulfate, elemental sulfur and Fe(III) nitrilotriacetate were not reduced as terminal electron acceptors. Aesculin was hydrolysed but not gelatin. Indole and H2S were produced from yeast extract. The G+C content of the genomic DNA was 51.2 mol%. The major cellular fatty acids were iso-C15 : 0, anteiso-C15 : 0 and C16 : 0. The most abundant polar lipid of strain RL-CT was phosphatidylethanolamine. 16S rRNA gene sequence analysis revealed that the isolate belongs to the uncultured Blvii28 wastewater-sludge group (http://www.arb-silva.de/) in the family Rikenellaceae of the phylum Bacteroidetes, and shared low sequence similarities with the related species Alistipes shahii WAL 8301T (81.8 %), Rikenella microfusus ATCC 29728T (81.7 %) and Anaerocella delicata WN081T (80.9 %). On the basis of these data, a novel species in a new genus of the family Rikenellaceae is proposed, Acetobacteroides hydrogenigenes gen. nov., sp. nov. The type strain of the type species is RL-CT ( = JCM 17603T = DSM 24657T = CGMCC 1.5173T).
Alzheimer’s disease (AD) is the most common form of dementia and numerous studies reported a higher prevalence and incidence of AD among women. Although women have longer lifetime, longevity does not ...wholly explain the higher frequency and lifetime risk in women. It is important to understand sex differences in AD pathophysiology and pathogenesis, which could provide foundation for future clinical AD research. Here, we reviewed the most recent and relevant literature on sex differences in biological change of AD from macroscopical neuroimaging to microscopical pathologic change (neuronal degeneration, synaptic dysfunction, amyloid-beta and tau accumulation). We also discussed sex differences in cellular mechanisms related to AD (neuroinflammation, mitochondria dysfunction, oxygen stress, apoptosis, autophagy, blood-brain-barrier dysfunction, gut microbiome alteration, bulk and single cell/nucleus omics) and possible causes underlying these differences including sex-chromosome, sex hormone and hypothalamic-pituitary- adrenal (HPA) axis effects.
•AD disproportionally affects women in the development, progression and clinical presentation of AD.•Our review summarized sex differences in biological change of AD from neuroimaging and electrophysiology to pathological change.•Our review summarized sex differences in mechanism from aspects of cellular process, pathogenic molecular and omics.•Sex-chromosome, sex hormone and HPA axis may the account for mechanisms of sex-divergence in AD.
To explore the effect of different emulsifier contents on the stability performance of biomass-emulsified asphalt, three types of emulsified asphalt with 1%, 3%, and 5% anionic emulsifiers were ...prepared and analyzed by molecular dynamics simulation and macroscopic experiments. Firstly, we used molecular simulation software (Material Studio, MS) to construct a model of biomass-emulsified asphalt with different emulsifier contents and analyzed the microscopic mechanism of the emulsifier to improve the stability of the emulsified asphalt by the radial distribution function, interaction energy, interfacial layer thickness, and solubility parameters of the emulsified asphalt system with different emulsifier contents. The results were validated by macro and micro tests including storage stability, particle size determination, and infrared spectroscopy. The results show that at low emulsifier contents, the emulsifier can reduce the interfacial tension between the oil–water interface and expand the transition region between the two phases (interfacial layer thickness), which will prevent interparticle agglomeration and reduce the emulsion particle size, thus reducing the settling rate and ensuring the stability of the emulsion. When the emulsifier content is further increased beyond the critical micelle concentration, the emulsifiers will agglomerate with each other and show larger peaks in the radial distribution function, and the phenomenon of emulsifier agglomeration will appear in the five-day storage stability test, resulting in a corresponding decrease in the proximity of the infrared absorption peak area ratio in the same wavelength band of the upper and lower layers of the biomass-emulsified asphalt, and the emulsion stability decreases instead.
The Boston Naming Test (BNT) is the most widely used measure to assess anomia. However, it has been criticized for failing to differentiate the underlying cognitive process of anomia.
We validated ...the color-picture version of BNT (CP-BNT) in a sample with diverse neurodegenerative dementia diseases (NDDs). We also verified the differential ability of the composite indices of CP-BNT across NDDs groups.
The present study included Alzheimer's disease (n = 132), semantic variant primary progressive aphasia (svPPA, n = 53), non-svPPA (n = 33), posterior cortical atrophy (PCA, n = 35), and normal controls (n = 110). We evaluated psychometric properties of CP-BNT for the spontaneous naming (SN), the percentage of correct responses on semantic cuing and word recognition cuing (% SC, % WR). Receiver operating characteristic analysis was used to examine the discriminatory power of SN alone and the composite indices (SN, % SC, and % WR).
The CP-BNT had sufficient internal consistency, good convergent, divergent validity, and criterion validity. Different indices of CP-BNT demonstrated distinct cognitive underpinnings. Category fluency was the strongest predictor of SN (β= 0.46, p < 0.001). Auditory comprehension tests highly associated with % WR (Sentence comprehension: β= 0.22, p = 0.001; Word comprehension: β= 0.20, p = 0.001), whereas a lower visuospatial score predicted % SC (β= -0.2, p = 0.001). Composite indices had better predictability than the SN alone when differentiating between NDDs, especially for PCA versus non-svPPA (area under the curve increased from 63.9% to 81.2%).
The CP-BNT is a highly linguistically relevant test with sufficient reliability and validity. Composite indices could provide more differential information beyond SN and should be used in clinical practice.
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