In this work, we systematically study the mass spectrum of the fully heavy tetraquark in an extended chromomagnetic model, which includes both color and chromomagnetic interactions. Numerical results ...indicate that the energy level is mainly determined by the color interaction, which favors the color-sextet |(QQ)6c (Q¯Q¯)6¯c ⟩ configuration over the color-triplet |(QQ)3¯c (Q¯Q¯)3c ⟩ one. The chromomagnetic interaction mixes the two color configurations and gives small splitting. The ground state is always dominated by the color-sextet configuration. We find no stable state below the lowest heavy quarkonium pair thresholds. Most states may be wide since they have at least one S-wave decay channel into two S-wave mesons. One possible narrow state is the 1+ bbb¯c¯ state with a mass 15719.1 MeV. It is just above the ηbB¯c threshold. But this channel is forbidden because of the conservation of the angular momentum and parity.
Systematics of fully heavy dibaryons Weng, Xin-Zhen; Zhu, Shi-Lin
The European physical journal. C, Particles and fields,
02/2024, Letnik:
84, Številka:
2
Journal Article
Recenzirano
Odprti dostop
We systematically study the mass spectra of the fully heavy dibaryons in an extended chromomagnetic model, which includes both the colorelectric and chromomagnetic interactions. We find no stable ...state below the corresponding baryon–baryon thresholds. Besides the masses, we also estimate the relative width ratios of the two-body decay channels. We hope our study will be of help for future experiments.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a DAP12-associated receptor expressed in microglia, macrophages, and other myeloid-derived cells. Previous studies have suggested that ...TREM2/DAP12 signaling pathway reduces inflammatory responses and promotes phagocytosis of apoptotic neurons. Recently, TREM2 has been identified as a risk gene for Alzheimer disease (AD). Here, we show that DAP12 stabilizes the C-terminal fragment of TREM2 (TREM2-CTF), a substrate for γ-secretase. Co-expression of DAP12 with TREM2 selectively increased the level of TREM2-CTF with little effects on that of full-length TREM2. The interaction between DAP12 and TREM2 is essential for TREM2-CTF stabilization as a mutant form of DAP12 with disrupted interaction with TREM2 failed to exhibit such an effect. Silencing of either Trem2 or Dap12 gene significantly exacerbated pro-inflammatory responses induced by lipopolysaccharides (LPS). Importantly, overexpression of either full-length TREM2 or TREM2-CTF reduced LPS-induced inflammatory responses. Taken together, our results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses.
TREM2 is a DAP12-coupled receptor associated with neurodegenerative diseases.
Co-expression of DAP12 increased the level of TREM2 C-terminal fragment (TREM2-CTF) which suppressed the release of pro-inflammatory cytokines.
A major function of DAP12 is to stabilize TREM2-CTF, which regulates inflammatory responses in microglia.
Our studies unraveled a novel function of DAP12 and provided new link between TREM2/DAP12 complexes and neuroinflammation.
In the present work, we study the Okubo-Zweig-Iizuka-allowed three body open flavor decay properties of higher vector charmonium and bottomonium states with an extended quark pair creation model. For ...the bottomonium system, we get that (i) the BBπ and B*B*π partial decay widths of the ϒ(10860) state are consistent with the experiment, and the BB*π partial decay width of the ϒ(10860) state is smaller but very close to Belle's experiment. Meanwhile, (ii) the BB*π and B*B*π decay widths of ϒ(11020) can reach 2–3 MeV. In addition, (iii) for most of the higher vector charmonium states, the partial decay widths of the DD*π and D*D*π modes can reach up to several MeV, which may be observed in future experiments.
In this paper, a three-dimensional (3D) hierarchical ZnO structure consisting of nanosheets modified with ultrafine NiO particles was synthesized via a facile two-step chemical precipitate method. ...Various techniques characterized the as-synthesized ZnO/NiO composites and pure ZnO. The p-NiO/n-ZnO junctions formed between adjacent ZnO and NiO nanoparticles, improving the gas sensing performance. The ZnO/NiO composite with the Ni:Zn atomic ratio of 7.42:100 exhibited the best isopropanol sensing properties. Compared to pure ZnO, it showed high selectivity and sensitivity (
R
a
/
R
g
= 221.3 toward 400 ×
10
-
6
isopropanol), fast response rate (less than 10 s), short recovery time, and simultaneously low operating temperature. Also, the ZnO/NiO composite exhibited a wide sensing range (1 ×
10
-
6
–1000 ×
10
-
6
) to isopropanol and processed good long-term stability. The experimental results suggested the potential application in fabricating efficient isopropanol sensors using this ZnO/NiO composite. The enhanced isopropanol sensing mechanism is also discussed in charge transfer between heterojunctions, surface area, and surface defects.
Graphic abstract
Accurate differential diagnosis among various dementias is crucial for effective treatment of Alzheimer's disease (AD). The study began with searching for novel blood-based neuronal extracellular ...vesicles (EVs) that are more enriched in the brain regions vulnerable to AD development and progression. With extensive proteomic profiling, GABRD and GPR162 were identified as novel brain regionally enriched plasma EVs markers. The performance of GABRD and GPR162, along with the AD molecule pTau217, was tested using the self-developed and optimized nanoflow cytometry-based technology, which not only detected the positive ratio of EVs but also concurrently presented the corresponding particle size of the EVs, in discovery (n = 310) and validation (n = 213) cohorts. Plasma GABRD
- or GPR162
-carrying pTau217-EVs were significantly reduced in AD compared with healthy control (HC). Additionally, the size distribution of GABRD
- and GPR162
-carrying pTau217-EVs were significantly different between AD and non-AD dementia (NAD). An integrative model, combining age, the number and corresponding size of the distribution of GABRD
- or GPR162
-carrying pTau217-EVs, accurately and sensitively discriminated AD from HC discovery cohort, area under the curve (AUC) = 0.96; validation cohort, AUC = 0.93 and effectively differentiated AD from NAD (discovery cohort, AUC = 0.91; validation cohort, AUC = 0.90). This study showed that brain regionally enriched neuronal EVs carrying pTau217 in plasma may serve as a robust diagnostic and differential diagnostic tool in both clinical practice and trials for AD.
To understand the facial emotion recognition of male veterans with chronic schizophrenia and the relationship between facial emotion recognition and interpersonal communication to provide a reference ...for designing social skills training programmes.
Fifty-six eligible male patients with chronic schizophrenia who were admitted to our hospital from October 2020 to April 2021 were selected, and 24 healthy people were selected as controls. Facial emotion recognition, social communication skills and self-perceived interpersonal disturbance were assessed using a facial emotion recognition stimulus manual, the Social Skills Checklist (SSC) and the Interpersonal Relationship Integrative Diagnostic Scale (IRIDS). Disease status was assessed using the Positive and Negative Syndrome Scale.
Both the control group and the patient group had the highest recognition accuracy for neutral faces. The recognition rate for neutral expression was higher in the control group than in the patient group (p = 0.008). The rate of neutral expressions identified as happiness was higher in the patient group than in the control group (p = 0.001). The identification of anger as happiness was higher in the control group than in the patient group (p = 0.026), and the pattern of misidentification was similar between the control group and the patient group. The accuracy of facial emotion recognition was negatively associated with the age of onset (p < 0.05). The recognition accuracy for happiness was negatively associated with negative symptoms, general pathological symptoms and total scale scores (p < 0.05). The total score for expression recognition was negatively associated with the negative symptom subscale scores (p < 0.05), and there was no correlation between expression recognition and positive symptoms (p > 0.05). The recognition accuracy for happiness was negatively correlated with the IRIDS conversation factor (p < 0.05). The recognition accuracy for happiness and anger and the total scores for facial emotion recognition were negatively correlated with the SSC subscale score and the total score (p < 0.05 and p < 0.01, respectively). The main influencing factors on facial emotion recognition were the SSC total score (p < 0.001) and the positive factor score (p = 0.039).
Veterans with chronic schizophrenia have facial emotion recognition impairments affected by negative symptoms. There is a correlation between facial emotion recognition and interpersonal communication.
1. There are extensive facial expression recognition disorders in schizophrenia. 2. The pattern of misidentification was similar in both the control group and the patient group, with the tendency for happiness to be identified as a neutral emotion, anger as happiness, and fear as neutral emotion and anger. 3. Based on the comprehensive assessment of social cognitive impairment in patients with schizophrenia, prospective studies of standardised interventions are designed to provide support for clinical practice.
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