This Letter reports the successful use of feedback from a spin polarization measurement to the revolution frequency of a 0.97 GeV/c bunched and polarized deuteron beam in the Cooler Synchrotron ...(COSY) storage ring in order to control both the precession rate (≈121 kHz) and the phase of the horizontal polarization component. Real time synchronization with a radio frequency (rf) solenoid made possible the rotation of the polarization out of the horizontal plane, yielding a demonstration of the feedback method to manipulate the polarization. In particular, the rotation rate shows a sinusoidal function of the horizontal polarization phase (relative to the rf solenoid), which was controlled to within a 1 standard deviation range of σ=0.21 rad. The minimum possible adjustment was 3.7 mHz out of a revolution frequency of 753 kHz, which changes the precession rate by 26 mrad/s. Such a capability meets a requirement for the use of storage rings to look for an intrinsic electric dipole moment of charged particles.
A series of heterocyclic compounds containing spirofused barbiturate and 3-azabicyclo3.1.0hexane frameworks have been studied as potential antitumor agents. Antiproliferative activity of products was ...screened in human erythroleukemia (K562), T lymphocyte (Jurkat), and cervical carcinoma (HeLa) as well as mouse colon carcinoma (CT26) and African green monkey kidney epithelial (Vero) cell lines. The most effective among the screened compounds show IC50 in the range from 4.2 to 24.1 μM for all tested cell lines. The screened compounds have demonstrated a significant effect of the distribution of HeLa and CT26 cells across the cell cycle stage, with accumulation of cells in SubG1 phase and induced apoptosis. It was found, using a confocal microscopy, that actin filaments disappeared and granular actin was distributed diffusely in the cytoplasm of up to 90% of HeLa cells and up to 64% of CT26 cells after treatment with tested 3-azaspirobicyclo 3.1.0hexane-2,5′-pyrimidines. We discovered that the number of HeLa cells with filopodium-like membrane protrusions was reduced significantly (from 91% in control cells to 35%) after treatment with the most active compounds. A decrease in cell motility was also noticed. Preliminary in vivo experiments on the impact of the studied compounds on the dynamics of CT26 tumor growth in Balb/C mice were also performed.
The sum of ions of the basic Lake Ladoga water mass has varied quite significantly from 55.6 to 71.6 mg/L over the past 60 years. In the present paper, separate periods of the mineralization growth ...are identified. It is shown that the change in the mineralization of Lake Ladoga has been always accompanied by a significant change in the ratio of basic ion concentrations. Any significant trends in the total mineralization of Lake Ladoga over the analyzed period have not been identified, but periods of the growth and decrease in the number of ions have been revealed. Until 1998, the periods of increased mineralization, as a rule, were accompanied by an increase in concentrations of
and
, most likely coming from the catchment area due to industrial and household pollution. During 2009–2019, the mineralization was growing mainly due to an increase in the absolute and relative concentrations of
. At the same time, the concentration of dissolved CO
2
in the main water mass of the lake also was increasing (and, consequently, pH was decreasing). Thus, the changes in the bicarbonate ion concentration in the water of Lake Ladoga may be largely determined by an increase in its inflow from the catchment area, whose possible reason is the enhancement of the chemical weathering of carbonate rocks due to the increasing concentrations of dissolved
in the water.
A new method to determine the spin tune is described and tested. In an ideal planar magnetic ring, the spin tune-defined as the number of spin precessions per turn-is given by ν(s)=γG (γ is the ...Lorentz factor, G the gyromagnetic anomaly). At 970 MeV/c, the deuteron spins coherently precess at a frequency of ≈120 kHz in the Cooler Synchrotron COSY. The spin tune is deduced from the up-down asymmetry of deuteron-carbon scattering. In a time interval of 2.6 s, the spin tune was determined with a precision of the order 10^{-8}, and to 1×10^{-10} for a continuous 100 s accelerator cycle. This renders the presented method a new precision tool for accelerator physics; controlling the spin motion of particles to high precision is mandatory, in particular, for the measurement of electric dipole moments of charged particles in a storage ring.
Based on the notion that the local dark-matter field of axions or axionlike particles (ALPs) in our Galaxy induces oscillating couplings to the spins of nucleons and nuclei (via the electric dipole ...moment of the latter and/or the paramagnetic axion-wind effect), we establish the feasibility of a new method to search for ALPs in storage rings. Based on previous work that allows us to maintain the in-plane polarization of a stored deuteron beam for a few hundred seconds, we perform a first proof-of-principle experiment at the Cooler Synchrotron (COSY) to scan momenta near 970 MeV/c. This entails a scan of the spin-precession frequency. At resonance between the spin-precession frequency of deuterons and the ALP-induced electric dipole moment (EDM) oscillation frequency, there is an accumulation of the polarization component out of the ring plane. Since the axion frequency is unknown, the momentum of the beam and, consequently, the spin-precession frequency are ramped to search for a vertical polarization change that occurs when the resonance is crossed. At COSY, four beam bunches with different polarization directions are used to make sure that no resonance is missed because of the unknown relative phase between the polarization precession and the axion or ALP field. A frequency window of 1.5 kHz width around the spin-precession frequency of 121 kHz is scanned. We describe the experimental procedure and a test of the methodology with the help of a radio-frequency Wien filter located on the COSY ring. No ALP resonance is observed. As a consequence, an upper limit of the oscillating EDM component of the deuteron as well as its axion coupling constants are provided.
A kinematically complete double-polarization measurement of the quasi-free np → {pp}sπ− reaction near threshold has been performed using the ANKE spectrometer at COSY-Jülich. Here {pp}s represents a ...two-proton system with an excitation energy less than 3 MeV. The transversely vector polarized deuteron beam and the internal polarized ANKE hydrogen target were used to determine the spin-correlation coefficients Ax,x and Ay,y. Events from the quasi-free np → dπ0 reaction were recorded simultaneously and used for both beam and target polarimetry. In addition, the product of the beam and target polarizations could be estimated from the Ay,y coefficient. The storage cell within the polarized target was the main source of background events. Dedicated runs, with no gas in the cell and with the cell filled with N2 gas, were taken to study the backgrounds. The data analysis procedure and the initial results of the experiment are presented.
Values of the proton analysing power, deuteron vector analysing power, and the deuteron-proton spin correlations in the pd → 3He π0/3Hπ+ reactions at 350-360 MeV per nucleon were obtained by using ...polarized beams and target at ANKE-COSY. Data were also obtained on the deuteron-proton spin correlation and proton analysing power at small angles at 600 MeV per nucleon. By combining the extrapolated values of the spin correlations to the forward or backward directions with published measurements of the deuteron tensor analysing powers, the relative phases between the two non-vanishing amplitudes were evaluated.
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