Over recent years, many coastal engineering projects have employed the use of soft solutions as these are generally less environmentally damaging than hard solutions. However, in some cases, local ...conditions hinder the use of soft solutions, meaning that hard solutions have to be adopted or, sometimes, a combination of hard and soft measures is seen as optimal. This research reviews the use of hard coastal structures on the foreshore (groynes, breakwaters and jetties) and onshore (seawalls and dikes). The purpose, functioning and local conditions for which these structures are most suitable are outlined. A description is provided on the negative effects that these structures may have on morphological, hydrodynamic and ecological conditions. To reduce or mitigate these negative impacts, or to create new ecosystem services, the following nature-based adaptations are proposed and discussed: (1) applying soft solutions complementary to hard solutions, (2) mitigating morphological and hydrodynamic changes and (3) ecologically enhancing hard coastal structures. The selection and also the success of these potential adaptations are highly dependent on local conditions, such as hydrodynamic forcing, spatial requirements and socioeconomic factors. The overview provided in this paper aims to offer an interdisciplinary understanding, by giving general guidance on which type of solution is suitable for given characteristics, taking into consideration all aspects that are key for environmentally sensitive coastal designs. Overall, this study aims to provide guidance at the interdisciplinary design stage of nature-based coastal defence structures.
BACKGROUND AND PURPOSE Bones are widely innervated, suggesting an important role for the sympathetic regulation of bone metabolism, although there are controversial studies. We investigated the ...effects of propranolol in a model of experimental periodontal disease.
EXPERIMENTAL APPROACH Rats were assigned as follows: animals without ligature; ligated animals receiving vehicle and ligated animals receiving 0.1, 5 or 20 mg·kg−1 propranolol. After 30 days, haemodynamic parameters were measured by cardiac catheterization. Gingival tissues were removed and assessed for IL‐1β, TNF‐α and cross‐linked carboxyterminal telopeptides of type I collagen (CTX) by elisa, or intercellular adhesion molecule 1 (ICAM‐1), receptor activator of NF‐κ B ligand (RANKL) and osteoprotegerin (OPG) by Western blot analysis. Sections from the mandibles were evaluated for bone resorption. Also, we analysed the ability of propranolol to inhibit osteoclastogenesis in vitro.
RESULTS Propranolol at 0.1 and 5 mg·kg−1 reduced the bone resorption as well as ICAM‐1 and RANKL expression. However, only 0.1 mg·kg−1 reduced IL‐1β, TNF‐α and CTX levels as well as increased the expression of OPG, but did not alter any of the haemodynamic parameters. Propranolol also suppressed in vitro osteoclast differentiation and resorptive activity by inhibiting the nuclear factor of activated T cells (NFATc)1 pathway and the expression of tartrate‐resistant acid phosphatase (TRAP), cathepsin K and MMP‐9.
CONCLUSIONS AND IMPLICATIONS Low doses of propranolol suppress bone resorption by inhibiting RANKL‐mediated osteoclastogenesis as well as inflammatory markers without affecting haemodynamic parameters.
The consumption of probiotic-enriched dairy products has been associated with many health benefits, including anti-hyperglycemic activity. The effect on health is dependent on the type of probiotic ...culture used and the dairy product consumed. This study evaluated the effect of different probiotic-enriched dairy matrices (Minas Frescal cheese, Prato cheese, and whey dairy beverage) containing Lactobacillus casei on in vitro and in vivo anti-hyperglycemic activity. For this purpose, in vitro anti-hyperglycemic activity was determined by the inhibition of α-glucosidase and α-amylase activities, and a human study was performed with healthy individuals (n = 15, consumption of bread as a control; bread + Minas Frescal cheese; bread + Prato cheese; bread + dairy beverage) to assess the effects of different probiotic foods on postprandial glycemia. In vitro data showed that Prato cheese presented the highest lipid (36.9 g/100 g) and protein (26.5 g/100 g) contents as well as the highest α-amylase (60.7%) and α-glucosidase (52.6%) inhibition. The consumption of Prato cheese resulted in a lesser increase in blood glucose level (13 mg/dL) compared with the consumption of bread alone (19 mg/dL), Minas Frescal cheese (20 mg/dL), and whey dairy beverage (30 mg/dL), with glycemic indices similar to that observed for the control. The present results demonstrated a good correlation between in vitro and in vivo data, in which the type of dairy matrix affects the anti-hyperglycemic activity. It is concluded that the consumption of probiotic Prato cheese can contribute to the reduction of postprandial glycemia in healthy individuals.
Twisted Laguerre-Gaussian lasers, with orbital angular momentum and characterized by doughnut-shaped intensity profiles, provide a transformative set of tools and research directions in a growing ...range of fields and applications, from super-resolution microcopy and ultra-fast optical communications to quantum computing and astrophysics. The impact of twisted light is widening as recent numerical calculations provided solutions to long-standing challenges in plasma-based acceleration by allowing for high-gradient positron acceleration. The production of ultra-high-intensity twisted laser pulses could then also have a broad influence on relativistic laser-matter interactions. Here we show theoretically and with ab initio three-dimensional particle-in-cell simulations that stimulated Raman backscattering can generate and amplify twisted lasers to petawatt intensities in plasmas. This work may open new research directions in nonlinear optics and high-energy-density science, compact plasma-based accelerators and light sources.
Highly photoluminescent carbon dots have been prepared in a one step procedure by hydrothermal treatment of formaldehyde at 180 °C. They show green fluorescence under UV light exposure and emission ...spectra are centered at 440 nm. Fluorescence lifetimes comprise between 0.7 and 2.70 ns, when the synthesis process lasted for 1-7 days. TEM images of nanoparticles showed a homogeneous size/shape distribution. When the thermal treatment process was carried out for a long time (30 days) formation of aggregates occurred. Carbon dots were further analyzed using (1)H and (13)C-NMR, Raman and FTIR spectroscopy techniques and XPS. Cell imaging of nanoparticles was carried out by using mouse MC3T3-E1 pre-osteoblasts as a model. The nanoparticles were selectively localized in the cytoplasm without further functionalization and could be realized by cellular phagocytosis, so that the fluorescence of these can be used for live cell imaging in vitro.
We identify and explore a high orbital angular momentum (OAM) harmonics generation and amplification mechanism that manipulates the OAM independently of any other laser property, by preserving the ...initial laser wavelength, through stimulated Raman backscattering in a plasma. The high OAM harmonics spectra can extend at least up to the limiting value imposed by the paraxial approximation. We show with theory and particle-in-cell simulations that the orders of the OAM harmonics can be tuned according to a selection rule that depends on the initial OAM of the interacting waves. We illustrate the high OAM harmonics generation in a plasma using several examples including the generation of prime OAM harmonics. The process can also be realized in any nonlinear optical Kerr media supporting three-wave interactions.
This study was aimed at developing a new functional fermented beverage manufactured with semi-skimmed sheep milk and strawberry pulp (Fragaria × ananassa Duch.) and commercial prebiotic ingredients. ...We also compared the performance of the yogurt starter cultures and a Lactobacillus plantarum strain (CECT_8328) with potential probiotic properties. We assessed the nutritional profile, bioactivity compounds, viability of lactic acid bacteria during storage, and survival of L. plantarum after in vitro simulated digestion during the storage period. The lactic acid bacteria were viable throughout the storage period, but only L. plantarum maintained good viability after simulated digestion. Nevertheless, neither inulin nor potato starch increased bacterial viability. The fermented semi-skimmed sheep milk strawberry beverages we developed are good sources of minerals and proteins.
Microwave magnetodynamics in ferromagnets are often studied in the small-amplitude or weakly nonlinear regime corresponding to modulations of a well-defined magnetic state. However, strongly ...nonlinear regimes, where the aforementioned approximations are not applicable, have become experimentally accessible. By reinterpreting the governing Landau-Lifshitz equation of motion, we derive an exact set of equations of dispersive hydrodynamic form that are amenable to analytical study even when full nonlinearity and exchange dispersion are included. The resulting equations are shown to, in general, break Galilean invariance. A magnetic Mach number is obtained as a function of static and moving reference frames. The simplest class of solutions are termed uniform hydrodynamic states (UHSs), which exhibit fluidlike behavior including laminar flow at subsonic speeds and the formation of a Mach cone and wave fronts at supersonic speeds. A regime of modulational instability is also possible, where the UHS is violently unstable. The hydrodynamic interpretation opens up novel possibilities in magnetic research.
The extracts of medicinal plants are used for the treatment of seeds in order to reduce the action of phytopathogens and increase the vigor of the seeds. Currently, computerized image analysis has ...been used to assess the physiological quality of seed lots. The objective was to evaluate the efficiency of the Vigor-S® software in the evaluation of the physiological quality of cowpea seeds treated with essential oils, comparing with a traditional test and the principal component analysis. Two cowpea cultivars were analyzed, BRS Tumucumaque and BRS Guariba, treated with doses of natural extracts of Alfavaca, garlic, horsetail, citronella and pyroligneous acid. The traditional method consisted of evaluations for germination, first germination count, seedling emergence, emergence speed index, accelerated aging, fresh matter and dry matter of seedling and the image analysis for: seedling length, growth index, uniformity index, vigor index, and germination. A Principal component analysis was applied to reduce the number of variables. Horsetail, Alfavaca and citronella extracts were efficient in increasing the physiological quality of the seeds of at least one cultivar. The Vigor-S® software proved to be efficient compared to traditional tests to assess the physiological quality of seeds. Principal Component Analysis is an ally to identify the best extracts and doses to be used. The image analysis method proved to be effective when compared to the traditional method and can therefore be used.
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