A total dose of 8 mg cadmium acetate/kg body weight was administered by repeated i.p. injection to female Wistar rats for 12 weeks. Slight, but significant, increases in blood pressure were recorded. ...The lipid concentration in serum and other tissues examined was not significantly affected, apart from a decrease in hepatic triglyceride. The blood cadmium (Cd) concentration was increased 10 times and Cd in the aortic wall was 4 times higher in treated rats. Cd affects hepatic lipid metabolism and it is considered that the increase in blood pressure is associated with accumulation of Cd in the arterial walls.
The arterial blood pressure, lipid content in serum and some organs, cadmium level in blood, aorta wall, lung and liver have been examined in rats repeatedly exposed to cadmium oxide fume 5 hours ...daily, 5 days a week, during 6 months. The blood pressure in rats exposed to cadmium oxide at concentration 0.02 mg Cd/m3 and 0.16 mg Cd/m3 was not changed, but it was slightly lowered at concentration 1.0 mg Cd/m3, which has been found lethal for rats. The concentration of total cholesterol, phospholipids and cholesterol esters in serum of female rats exposed at concentration of 0.16 mg Cd/m3 for 3 months was decreased, but was not affected after 6 months of exposure. The content of cholesterol and triglycerides in aorta wall, heart and liver was unchanged, although the content of cholesterol was decreased in adrenals of rats exposed for 3 months at concentration of 0.16 mg Cd/m3. Inhalation of cadmium oxide brought about the marked increase of Cd content in lung and kidney of rats exposed at all concentrations an increase of Cd blood level in rats exposed at concentrations of 0.16 mg Cd/m3 and 1.0 mg Cd/m3 and no increase of Cd content in aorta wall.
The study was aimed at evaluation of the effects of trioxane and dioxolane on the fertility and frequency of dominant lethal mutations in germ cells of male rats. In the first experiment each test ...compound was administered per os at doses of 0,1 LD50 or 0,2 LD50 to male rats once a day, 5 days a week, throughout 8 weeks. During every week of treatment each male was mated with two females. In the second experiment, male rats exposed by inhalation 5 hours daily, 5 days a week, for 12 months, to trioxane or dioxolane at concentrations of 2500 mg/m3 were mated through one week with female rats in ratio 1:2. The autopsy of dams was carried out 13-14 days after the middle of mating intervals. No increase in the number of preimplantation losses, dead implants and alive fetuses per female was noted in any treated group as compared to an appropriate control group. The test noted in any treated group as compared to an appropriate control group. The test compounds did not affect the fertility of males, although in some rats treated with trioxane or dioxolane microscopic examination of testes revealed focal necrosis of seminiferous epithelium and alteration of spermatogenesis. The study did not reveal induced dominant lethal mutations in germ cells of male rats treated per os or by inhalation with trioxane or dioxolane.
