Any asymmetry in energy of the colliding beams will lead to a longitudinal boost of the center-of-mass frame of colliding particles w.r.t. the laboratory frame and consequently to the counting loss ...in luminometer due to the loss of colinearity of Bhabha final states. At CEPC running at the Z0 pole, asymmetry in energy of the colliding beams should be known as well as 12.5% of the beam-spread, in order to control the uncertainty of Bhabha count at the level of 0.01%. Here we discuss the method, initially proposed for FCCee, to determine variation of the beam-spread from the measurement of the effective center-of-mass energy in \(e^+e^- \to \mu^+\mu^-\) collisions.
The levels of 1-min mean ambient particles with an aerodynamic diameter up to 1 µm (PM1) recorded at two nearby measuring sites in a residential area of Zagreb, Croatia, were analyzed with respect to ...the meteorological conditions (air pressure, horizontal and vertical wind speed, wind direction, global radiation, air temperature and relative humidity) and local traffic. PM1 mass concentrations were measured using a Model 8520 DUSTTRAK™ Aerosol Monitor (TSI Inc., Shoreview, MN, USA). One measuring site was placed next to a road with weak to moderate traffic, and the other was on a roof terrace approximately 100 m east of that road; the heights of the aerosol monitor inlet were at 1.7 m (road) and 15.8 m (roof) above the ground level (AGL). Both road and the roof experiments were performed by the same instrument, and thus, they correspond to different time intervals. The roof results show that nearby roads do not affect the PM1 concentrations at the site 100 m from the road, while, according to preliminary road results, the effects of the local traffic appear only if more than 22 vehicles per minute pass by the instrument. However, PM1 levels seem to be strongly affected by traffic occurring in the more distant areas of Zagreb. Additionally, the results for certain wind directions also exhibit the influence of the regional and/or long-range transport of pollution on PM1 levels. Finally, it is shown that 1-min mean PM1 mass concentrations depend on the 1-min mean meteorological variables investigated. Keywords: advection of particles, ambient concentrations, DUSTTRAK™ Aerosol Monitor, traffic density, 1-min mean Analizirane su 1-minutne masene koncentracije lebdecih cestica aerodinamickog promjera do 1 cim (PM1) i njihova ovisnost o meteoroloskim uvjetima (tlaku zraka, brzini horizontalnog i vertikalnog vjetra, smjeru vjetra, globalnom zracenju, temperaturi zraka i relativnoj vlanosti) te ovisnost koncentracija o gustoci prometa. Koncentracije PM1 mjerene su na dva bliska mjerna mjesta u rezidencijalnom dijelu Zagreba pomocu 8520 DUSTTRAK™ aerosol monitora (TSI Inc., Shoreview, MN, USA). Jedno mjerno mjesto nalazilo se uz samu prometnicu sa slabim do umjerenim prometom, a drugo na krovnoj terasi priblizno 100 m istocno od prometnice. Visine instrumenta bile su na 1.7 m (uz cestu) i 15.8 m (na krovu) nad tlom. Oba eksperimenta provedena su istim mjernim instrumentom, te se stoga odnose na razlicite vremenske intervale. Rezultati mjerenja na krovu pokazuju da obliznja prometnica s rijetkim do umjerenim prometom ne utjece na koncentracije PM1 u tocki udaljenoj oko 100 m od ceste. Preliminarni rezultati mjerenja uz cestu pokazuju da lokalni promet utjece na koncentracije tek pri vecoj gustoci prometa, odnosno ako u jednoj minuti pokraj instrumenta produ bar 22 vozila. Medutim, cini se da na koncentracije PM1 u sjevernom rezidencijalnom dijelu Zagreba jako utjecu udaljeniji dijelovi grada. Rezultati dobiveni za neke smjerove vjetra ukazuju na utjecaj regionalnog i/ili daljinskog transporta na razine PM1. Konacno, pokazuje se da 1-minutni srednjaci masene koncentracije PM1 ovise o 1-minutnim vrijednostima meteoroloskih varijabli. Kljucne rijeci: advekcija cestica, koncentracije, DUSTTRAK™ Aerosol Monitor, gustoca prometa, 1-minutni srednjak
The very forward region is one of the most challenging regions to instrument at a future \(e^+e^-\) collider. At CEPC, machine-detector interface includes, among others, a calorimeter dedicated for ...precision measurement of the integrated luminosity at a per mill level or better. Here we review a feasibility of such precision, from the point of view systematic effects arising from luminometer mechanical precision and positioning, beam-related requirements and physics background from two-photon processes. The impact of the beam energy spread and its uncertainty on the integrated luminosity precision is also discussed, as well as the achievable beam energy spread precision with the post-CDR CEPC beams.
Analizirane su 1-minutne masene koncentracije lebdećih čestica aerodinamičkog promjera do 1 μm (PM1) i njihova ovisnost o meteorološkim uvjetima (tlaku zraka, brzini horizontalnog i vertikalnog ...vjetra, smjeru vjetra, globalnom zračenju, temperaturi zraka i relativnoj vlažnosti) te ovisnost koncentracija o gustoći prometa. Koncentracije PM1 mjerene su na dva bliska mjerna mjesta u rezidencijalnom dijelu Zagreba pomoću 8520 DUSTTRAKTM aerosol monitora (TSI Inc., Shoreview, MN, USA). Jedno mjerno mjesto nalazilo se uz samu prometnicu sa slabim do umjerenim prometom, a drugo na krovnoj terasi približno 100 m istočno od prometnice. visine instrumenta bile su na 1.7 m (uz cestu) i 15.8 m (na krovu) nad tlom. Oba eksperimenta provedena su istim mjernim instrumentom, te se stoga odnose na različite vremenske intervale. Rezultati mjerenja na krovu pokazuju da obližnja prometnica s rijetkim do umjerenim prometom ne utječe na koncentracije PM1 u točki udaljenoj oko 100 m od ceste. Preliminarni rezultati mjerenja uz cestu pokazuju da lokalni promet utječe na koncentracije tek pri većoj gustoći prometa, odnosno ako u jednoj minuti pokraj instrumenta prođu bar 22 vozila. Međutim, čini se da na koncentracije PM1 u sjevernom rezidencijalnom dijelu Zagreba jako utječu udaljeniji dijelovi grada. Rezultati dobiveni za neke smjerove vjetra ukazuju na utjecaj regionalnog i/ili daljinskog transporta na razine PM1. Konačno, pokazuje se da 1-minutni srednjaci masene koncentracije PM1 ovise o 1-minutnim vrijednostima meteoroloških varijabli.
Two special calorimeters are foreseen for the instrumentation of the very forward region of the ILC detector, a luminometer designed to measure the rate of low angle Bhabha scattering events with a ...precision better than 10-3 and a low polar angle calorimeter, adjacent to the beam-pipe. The latter will be hit by a large amount of beamstrahlung remnants. The amount and shape of these depositions will allow a fast luminosity estimate and the determination of beam parameters. The sensors of this calorimeter must be radiation hard. Both devices will improve the hermeticity of the detector in the search for new particles. Finely segmented and very compact calorimeters will match the requirements. Due to the high occupancy fast front-end electronics is needed. The design of the calorimeters developed and optimised with Monte Carlo simulations is presented. Sensors and readout electronics ASICs have been designed and prototypes are available. Results on the performance of these major components are summarised.
Heart failure (HF) is a complex clinical condition characterized by functional and structural defects of the myocardium, but genetic and environmental factors are considered to play an important role ...in the development of the disease. In the present study, we investigated the genome instability (DNA and chromosomal damage) in patients with heart failure with reduced ejection fraction (HFrEF) ≤40% and its association with risk factors. The studied population included 48 individuals, of which 29 HFrEF patients (mean age 57.41 ± 5.74 years) and 19 healthy controls (mean age 57.63 ± 6.09 years). The genetic damage index in peripheral blood lymphocytes was analyzed using the comet assay, while micronuclei frequency and nuclear division index were analyzed using the cytokinesis-block micronucleus assay. Our results showed that HFrEF patients had a significantly higher genetic damage index compared with the healthy controls (P < .001). Cytokinesis-block micronucleus assay showed that the average micronucleus frequency in peripheral blood lymphocytes of patients was significantly higher, while the nuclear division index values were significantly lower than in controls (P < .01). Using multiple linear regression analysis, pathological state, ejection fraction, creatinine, glucose, associated disease, residence, proBNP, troponin, urea, ACE-inhibitors, and length of the drug therapy were identified as predictors of DNA and/or chromosomal damage in HF patients. We can conclude that DNA and chromosomal damage was increased in patients with HF, which may be a consequence of disease and/or drug therapy.
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