An update on androgen-deprivation therapy in prostate cancer and cardiovascular risk based on medical research brought by the American Heart Association, American Cancer Society, and American ...Urological Association, is presented.
ABSTRACT All-sky multiband photometric surveys represent a unique opportunity of exploring rich nearby galaxy clusters up to several virial radii, reaching the filament regions where pre-processing ...is expected to occur. These projects aim to tackle a large number of astrophysical topics, encompassing both the Galactic and extragalactic fields. In that sense, generating large catalogues with homogeneous photometry for both resolved and unresolved sources that might be interesting to achieve specific goals, imposes a compromise when choosing the set of parameters to automatically detect and measure such a plethora of objects. In this work, we present the acquired experience on studying the galaxy content of the Fornax cluster using large catalogues obtained by the Southern Photometric Local Universe Survey (S-PLUS). We realized that some Fornax bright galaxies are missed in the S-PLUS iDR4 catalogues. In addition, Fornax star-forming galaxies are included as multiple detections due to overdeblending. To solve those issues, we performed specific SExtractor runs to identify the proper set of parameters to recover as many Fornax galaxies as possible with confident photometry and avoiding duplications. From that process, we obtained new catalogues containing 12-band improved photometry for ∼ 3 × 106 resolved and unresolved sources in an area of ∼ 208 deg2 in the direction of the Fornax cluster. Together with identifying the main difficulties to carry out the study of nearby groups and clusters of galaxies using S-PLUS catalogues, we also share possible solutions to face issues that seem to be common to other ongoing photometric surveys.
Cooling of beams of gold ions using electron bunches accelerated with radio-frequency systems was recently experimentally demonstrated in the Relativistic Heavy Ion Collider at Brookhaven National ...Laboratory. Such an approach is new and opens the possibility of using this technique at higher energies than possible with electrostatic acceleration of electron beams. The challenges of this approach include generation of electron beams suitable for cooling, delivery of electron bunches of the required quality to the cooling sections without degradation of beam angular divergence and energy spread, achieving the required small angles between electron and ion trajectories in the cooling sections, precise velocity matching between the two beams, high-current operation of the electron accelerator, as well as several physics effects related to bunched-beam cooling. Here we report on the first demonstration of cooling hadron beams using this new approach.
We use the first data release from the SINGG Ha survey of H i-selected galaxies to study the quantitative behavior of the diffuse, warm ionized medium (WIM) across the range of properties represented ...by these 109 galaxies. The mean fraction fwim of diffuse ionized gas in this sample is 0.59 plus or minus 0. 19, slightly higher than found in previous samples. Since lower surface brightness galaxies tend to have higher fwim, we believe that most of this difference is due to selection effects favoring large, optically bright, nearby galaxies with high star formation rates. As found in previous studies, there is no appreciable correlation with Hubble type or total star formation rate. However, we find that starburst galaxies, defined here by an Ha surface brightness > 2.5 x 10 super(39) erg super(-) sub(8) super(1) kpe super(-2) within the H alpha half-light radius, do show much lower fractions of diffuse Ha emission. The cause apparently is not dominated by a lower fraction of field OB stars. However, it is qualitatively consistent with an expected escape of ionizing radiation above a threshold star formation rate, predicted from our model in which the ISM is shredded by pressure-driven supernova feedback. The H i gas fractions in the starburst galaxies are also lower, suggesting that the starbursts are consuming and ionizing all the gas, and thus promoting regions of density-bounded ionization. If true, these effects Imply that some amount of Lyman continuum radiation is escaping from most starburst galaxies, and that WIM properties and outflows from mechanical feedback are likely to be pressure-driven. However, in view of previous studies showing that the escape fraction of ionizing radiation Is generally low, it is likely that other factors also drive the low fractions of diffuse ionized gas in starbursts.
We present new precision measurements of the elastic electron-proton scattering cross section for momentum transfer (Q^{2}) up to 15.75 (GeV/c)^{2}. Combined with existing data, these provide an ...improved extraction of the proton magnetic form factor at high Q^{2} and double the range over which a longitudinal or transverse separation of the cross section can be performed. The difference between our results and polarization data agrees with that observed at lower Q^{2} and attributed to hard two-photon exchange (TPE) effects, extending to 8 (GeV/c)^{2} the range of Q^{2} for which a discrepancy is established at >95% confidence. We use the discrepancy to quantify the size of TPE contributions needed to explain the cross section at high Q^{2}.
Most radiative transfer models assume that dust in spiral galaxies is distributed exponentially. In this paper our goal is to verify this assumption by analysing the two-dimensional large-scale ...distribution of dust in galaxies from the DustPedia sample. For this purpose, we have made use of Herschel imaging in five bands, from 100 to 500 μm, in which the cold dust constituent is primarily traced and makes up the bulk of the dust mass in spiral galaxies. For a subsample of 320 disc galaxies, we successfully performed a simultaneous fitting with a single Sérsic model of the Herschel images in all five bands using the multi-band modelling code GALFITM. We report that the Sérsic index n, which characterises the shape of the Sérsic profile, lies systematically below 1 in all Herschel bands and is almost constant with wavelength. The average value at 250 μm is 0.67 ± 0.37 (187 galaxies are fitted with n250 ≤ 0.75, 87 galaxies have 0.75 < n250 ≤ 1.25, and 46 – with n250 > 1.25). Most observed profiles exhibit a depletion in the inner region (at r < 0.3−0.4 of the optical radius r25) and are more or less exponential in the outer part. We also find breaks in the dust emission profiles at longer distances (0.5−0.6) r25 which are associated with the breaks in the optical and near-infrared. We assumed that the observed deficit of dust emission in the inner galaxy region is related to the depression in the radial profile of the HI surface density in the same region because the atomic gas reaches high enough surface densities there to be transformed into molecular gas. If a galaxy has a triggered star formation in the inner region (for example, because of a strong bar instability, which transfers the gas inwards to the centre, or a pseudobulge formation), no depletion or even an excess of dust emission in the centre is observed.
Background
People with intellectual disabilities are more likely to experience poor health than the general population and are frequently prescribed multiple medications. Therefore, it is important ...that people with intellectual disabilities understand their medication and potential adverse effects.
Method
A scoping review explored people with intellectual disabilities' knowledge of prescription medications, their risks and how medication understanding can be improved.
Results
Ten journal articles were included. People with intellectual disabilities often lacked understanding of their medication, including its name, purpose and when and how to take it. Participants were often confused or unaware of adverse effects associated with their medication. Information was sometimes explained to carers rather than people with intellectual disabilities. Some interventions and accessible information helped to improve knowledge in people with intellectual disabilities.
Conclusion
There is a need for accessible and tailored information about medication to be discussed with people with intellectual disabilities in order to meet legal and best practice standards.
Background
Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Approximately 15–20% of patients develop symptoms before their 18th birthday and are diagnosed with ...juvenile-onset SLE (JSLE). Gender distribution, clinical presentation, disease courses and outcomes vary significantly between JSLE patients and individuals with adult-onset SLE. This study aimed to identify age-specific clinical and/or serological patterns in JSLE patients enrolled to the UK JSLE Cohort Study.
Methods
Patient records were accessed and grouped based on age at disease-onset: pre-pubertal (≤7 years), peri-pubertal (8–13 years) and adolescent (14–18 years). The presence of American College of Rheumatology (ACR) classification criteria, laboratory results, disease activity British Isles Lupus Assessment Group (BILAG) and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2 K) scores and damage Systemic Lupus International Collaborating Clinics (SLICC) damage index were evaluated at diagnosis and last follow up.
Results
A total of 418 JSLE patients were included in this study: 43 (10.3%) with pre-pubertal disease onset; 240 (57.4%) with peri-pubertal onset and 135 (32.3%) were diagnosed during adolescence. At diagnosis, adolescent JSLE patients presented with a higher number of ACR criteria when compared with pre-pubertal and peri-pubertal patients pBILAG2004 scores: 9(4–20 vs. 7(3–13 vs. 7(3–14, respectively, p = 0.015 with increased activity in the following BILAG domains: mucocutaneous (p = 0.025), musculoskeletal (p = 0.029), renal (p = 0.027) and cardiorespiratory (p = 0.001). Furthermore, adolescent JSLE patients were more frequently ANA-positive (p = 0.034) and exhibited higher anti-dsDNA titres (p = 0.001). Pre-pubertal individuals less frequently presented with leukopenia (p = 0.002), thrombocytopenia (p = 0.004) or low complement (p = 0.002) when compared with other age groups. No differences were identified in disease activity (pBILAG2004 score), damage (SLICC damage index) and the number of ACR criteria fulfilled at last follow up.
Conclusions
Disease presentations and laboratory findings vary significantly between age groups within a national cohort of JSLE patients. Patients diagnosed during adolescence exhibit greater disease activity and “classic” autoantibody, immune cell and complement patterns when compared with younger patients. This supports the hypothesis that pathomechanisms may vary between patient age groups.
ABSTRACT
We present optical and near-infrared (NIR) observations of the Type Icn supernova (SN Icn) 2022ann, the fifth member of its newly identified class of SNe. Its early optical spectra are ...dominated by narrow carbon and oxygen P-Cygni features with absorption velocities of ∼800 km s−1; slower than other SNe Icn and indicative of interaction with a dense, H/He-poor circumstellar medium (CSM) that is outflowing slower than typical Wolf–Rayet wind velocities of >1000 km s−1. We identify helium in NIR spectra 2 weeks after maximum and in optical spectra at 3 weeks, demonstrating that the CSM is not fully devoid of helium. Unlike other SNe Icn, the spectra of SN 2022ann never develop broad features from SN ejecta, including in the nebular phase. Compared to other SNe Icn, SN 2022ann has a low luminosity (o-band absolute magnitude of ∼−17.7), and evolves slowly. The bolometric light curve is well-modelled by 4.8 M⊙ of SN ejecta interacting with 1.3 M⊙ of CSM. We place an upper limit of 0.04 M⊙ of 56Ni synthesized in the explosion. The host galaxy is a dwarf galaxy with a stellar mass of 107.34 M⊙ (implied metallicity of log(Z/Z⊙) ≈ 0.10) and integrated star-formation rate of log (SFR) = −2.20 M⊙ yr−1; both lower than 97 per cent of galaxies observed to produce core-collapse supernovae, although consistent with star-forming galaxies on the galaxy Main Sequence. The low CSM velocity, nickel and ejecta masses, and likely low-metallicity environment disfavour a single Wolf–Rayet progenitor star. Instead, a binary companion is likely required to adequately strip the progenitor and produce a low-velocity outflow.
BackgroundUptake of some childhood immunisations in the UK is lower among those from some Black and Asian Minority Ethnic (BAME) backgrounds. This systematic review of qualitative research sought to ...understand the factors that are associated with ethnicity that influence the immunisation decisions of parents from BAME backgrounds living in the UK.MethodsDatabases were searched on 2 December 2014 for studies published at any time using the terms ‘UK’ and ‘vaccination’ and ‘qualitative methods’ (and variations of these). Included articles comprised participants who were parents from BAME backgrounds. Thematic synthesis methods were used to develop descriptive and higher order themes. Themes specific to ethnicity and associated factors are reported.ResultsEight papers were included in the review. Most participants were from Black (n=62) or Asian (n=38) backgrounds. Two ethnicity-related factors affected immunisation decisions. First, factors that are related to ethnicity itself (namely religion, upbringing and migration, and language) affected parents' perceived importance of immunisations, whether immunisations were permitted or culturally acceptable and their understanding of immunisation/the immunisation schedule. Second, perceived biological differences affected decision-making and demand for information.ConclusionsFactors related to ethnicity must be considered when seeking to understand immunisation decisions among parents from BAME backgrounds. Where appropriate and feasible, vaccination information should be targeted to address beliefs about ethnic differences held by some individuals from some BAME backgrounds.
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