Résumé L’intégration du cycle de la vie ( lifespan integration , Pace, 2014) est actuellement employée comme approche psychothérapeutique du trauma, des troubles anxieux et des troubles dissociatifs. ...L’objectif du présent article est d’en exposer les présupposés théoriques et les applications cliniques, en les illustrant à l’aide d’un cas clinique. Les présupposés théoriques de l’ICV se basent sur les découvertes portant sur le développement cérébral, la régulation émotionnelle et la construction du Soi au cours des toutes premières années de vie (Schore, 2003). Les différents protocoles employés en ICV visent soit à intégrer des expériences traumatiques ou douloureuses ponctuelles, soit à réparer les blessures d’attachement pour consolider le Soi et la qualité de la régulation émotionnelle. L’étude d’un cas clinique développe ces deux applications ainsi que leurs résultats positifs dans le cas d’une femme de 28 ans souffrant d’attaques de panique et d’hypochondrie. L’ICV est une approche thérapeutique prometteuse des troubles dissociatifs ou post-traumatiques et nécessite d’être étudiée plus avant par la recherche.
The combustion of fossil fuels produces emissions of the long-lived greenhouse gas carbon dioxide and of short-lived pollutants, including sulfur dioxide, that contribute to the formation of ...atmospheric aerosols
. Atmospheric aerosols can cool the climate, masking some of the warming effect that results from the emission of greenhouse gases
. However, aerosol particulates are highly toxic when inhaled, leading to millions of premature deaths per year
. The phasing out of unabated fossil-fuel combustion will therefore provide health benefits, but will also reduce the extent to which the warming induced by greenhouse gases is masked by aerosols. Because aerosol levels respond much more rapidly to changes in emissions relative to carbon dioxide, large near-term increases in the magnitude and rate of climate warming are predicted in many idealized studies that typically assume an instantaneous removal of all anthropogenic or fossil-fuel-related emissions
. Here we show that more realistic modelling scenarios do not produce a substantial near-term increase in either the magnitude or the rate of warming, and in fact can lead to a decrease in warming rates within two decades of the start of the fossil-fuel phase-out. Accounting for the time required to transform power generation, industry and transportation leads to gradually increasing and largely offsetting climate impacts of carbon dioxide and sulfur dioxide, with the rate of warming further slowed by reductions in fossil-methane emissions. Our results indicate that even the most aggressive plausible transition to a clean-energy society provides benefits for climate change mitigation and air quality at essentially all decadal to centennial timescales.
We present accurate resolved WISE photometry of galaxies in the combined SINGS and KINGFISH sample. The luminosities in the W3 12 m and W4 23 m bands are calibrated to star formation rates (SFRs) ...derived using the total infrared luminosity, avoiding UV/optical uncertainties due to dust extinction corrections. The W3 relation has a 1 scatter of 0.15 dex that is over nearly 5 orders of magnitude in SFR and 12 m luminosity, and a range in host stellar mass from dwarfs (107 ) to (1011.5 ) galaxies. In the absence of deep silicate absorption features and powerful active galactic nuclei, we expect this to be a reliable SFR indicator chiefly due to the broad nature of the W3 band. By contrast, the W4 SFR relation shows more scatter (1 dex). Both relations show reasonable agreement with radio-continuum-derived SFRs and excellent accordance with so-called "hybrid" H + 24 m and FUV+24 m indicators. Moreover, the WISE SFR relations appear to be insensitive to the metallicity range in the sample. We also compare our results with IRAS-selected luminous infrared galaxies, showing that the WISE relations maintain concordance, but systematically deviate for the most extreme galaxies. Given the all-sky coverage of WISE and the performance of the W3 band as an SFR indicator, the SFR relation could be of great use to studies of nearby galaxies and forthcoming large-area surveys at optical and radio wavelengths.
Chronic pain is highly prevalent worldwide and represents a significant socioeconomic and public health burden. Several aspects of chronic pain, for example back pain and a severity-related phenotype ...'chronic pain grade', have been shown previously to be complex heritable traits with a polygenic component. Additional pain-related phenotypes capturing aspects of an individual's overall sensitivity to experiencing and reporting chronic pain have also been suggested as a focus for investigation. We made use of a measure of the number of sites of chronic pain in individuals within the UK general population. This measure, termed Multisite Chronic Pain (MCP), is a complex trait and its genetic architecture has not previously been investigated. To address this, we carried out a large-scale genome-wide association study (GWAS) of MCP in ~380,000 UK Biobank participants. Our findings were consistent with MCP having a significant polygenic component, with a Single Nucleotide Polymorphism (SNP) heritability of 10.2%. In total 76 independent lead SNPs at 39 risk loci were associated with MCP. Additional gene-level association analyses identified neurogenesis, synaptic plasticity, nervous system development, cell-cycle progression and apoptosis genes as enriched for genetic association with MCP. Genetic correlations were observed between MCP and a range of psychiatric, autoimmune and anthropometric traits, including major depressive disorder (MDD), asthma and Body Mass Index (BMI). Furthermore, in Mendelian randomisation (MR) analyses a causal effect of MCP on MDD was observed. Additionally, a polygenic risk score (PRS) for MCP was found to significantly predict chronic widespread pain (pain all over the body), indicating the existence of genetic variants contributing to both of these pain phenotypes. Overall, our findings support the proposition that chronic pain involves a strong nervous system component with implications for our understanding of the physiology of chronic pain. These discoveries may also inform the future development of novel treatment approaches.
•Surveys literature starting from 1950s era military applications.•Covers interdiction problems dealing with asymmetric information and stochasticity.•Focuses on mathematical programming based ...analyses of interdiction problems.
This paper discusses the development of interdiction optimization models and algorithms, with an emphasis on mathematical programming techniques and future research challenges in the field. After presenting basic interdiction concepts and notation, we recount the motivation and models behind founding research in the network interdiction field. Next, we examine some of the most common means of solving interdiction problems, focusing on dualization models and extended formulations solvable by row-generation techniques. We then examine contemporary interdiction problems involving incomplete information, information asymmetry, stochasticity, and dynamic play. We conclude by discussing several emerging applications in the field of network interdiction.
•We determined the CML AGE content in cooked meat prepared by pan frying, broiling, and baking.•Broiling and frying at higher temperatures produced higher CML levels, esp. in beef.•Baked salmon and ...tilapia contained lower CML amounts than other muscle foods.
Advanced glycation endproducts (AGEs), a pathogenic factor implicated in diabetes and other chronic diseases, are produced in cooked meat products. The objective of this study was to determine the AGE content, as measured by Nε-carboxymethyllysine (CML) levels, in cooked chicken, pork, beef and fish (salmon and tilapia) prepared by three common cooking methods used by U.S. consumers: frying, baking, and broiling. The CML was detected in all the cooked samples, but the levels were dependent on types of meat, cooking conditions, and the final internal temperature. Broiling and frying at higher cooking temperature produced higher levels of CML, and broiled beef contained the highest CML content (21.8μg/g). Baked salmon (8.6μg/g) and baked tilapia (9.7μg/g) contained less CML as compared to the other muscle food samples.
Disease conditions affecting the canine prostate gland are encountered frequently in small animal practice. The most common conditions affecting the canine prostate include benign prostatic ...hyperplasia, prostatitis, prostatic cysts, and prostatic neoplasia. Clinical signs associated with each of these conditions often overlap; therefore, it is important to reach a definitive diagnosis prior to initiating treatment. This paper reviews the diseases associated with the prostate gland of the dog, their diagnosis, as well as current treatment options for management of these conditions. Emphasis is placed on proper diagnostic sampling of the prostate gland, its fluid, and interpretation of findings, as well as emerging medical options for treatment of canine prostatic disease.
Nomograms in oncology: more than meets the eye Balachandran, Vinod P, Dr; Gonen, Mithat, PhD; Smith, J Joshua, MD ...
The lancet oncology,
04/2015, Letnik:
16, Številka:
4
Journal Article
Recenzirano
Odprti dostop
Summary Nomograms are widely used as prognostic devices in oncology and medicine. With the ability to generate an individual probability of a clinical event by integrating diverse prognostic and ...determinant variables, nomograms meet our desire for biologically and clinically integrated models and fulfill our drive towards personalised medicine. Rapid computation through user-friendly digital interfaces, together with increased accuracy, and more easily understood prognoses compared with conventional staging, allow for seamless incorporation of nomogram-derived prognosis to aid clinical decision making. This has led to the appearance of many nomograms on the internet and in medical journals, and an increase in nomogram use by patients and physicians alike. However, the statistical foundations of nomogram construction, their precise interpretation, and evidence supporting their use are generally misunderstood. This issue is leading to an under-appreciation of the inherent uncertainties regarding nomogram use. We provide a systematic, practical approach to evaluating and comprehending nomogram-derived prognoses, with particular emphasis on clarifying common misconceptions and highlighting limitations.
Urgent solutions to global climate change are needed. Ambitious tree‐planting initiatives, many already underway, aim to sequester enormous quantities of carbon to partly compensate for anthropogenic ...CO2 emissions, which are a major cause of rising global temperatures. However, tree planting that is poorly planned and executed could actually increase CO2 emissions and have long‐term, deleterious impacts on biodiversity, landscapes and livelihoods. Here, we highlight the main environmental risks of large‐scale tree planting and propose 10 golden rules, based on some of the most recent ecological research, to implement forest ecosystem restoration that maximizes rates of both carbon sequestration and biodiversity recovery while improving livelihoods. These are as follows: (1) Protect existing forest first; (2) Work together (involving all stakeholders); (3) Aim to maximize biodiversity recovery to meet multiple goals; (4) Select appropriate areas for restoration; (5) Use natural regeneration wherever possible; (6) Select species to maximize biodiversity; (7) Use resilient plant material (with appropriate genetic variability and provenance); (8) Plan ahead for infrastructure, capacity and seed supply; (9) Learn by doing (using an adaptive management approach); and (10) Make it pay (ensuring the economic sustainability of the project). We focus on the design of long‐term strategies to tackle the climate and biodiversity crises and support livelihood needs. We emphasize the role of local communities as sources of indigenous knowledge, and the benefits they could derive from successful reforestation that restores ecosystem functioning and delivers a diverse range of forest products and services. While there is no simple and universal recipe for forest restoration, it is crucial to build upon the currently growing public and private interest in this topic, to ensure interventions provide effective, long‐term carbon sinks and maximize benefits for biodiversity and people.
Ten golden rules_graphical Written Summary:We propose ten golden rules for reforestation to optimize carbon sequestration, biodiversity recovery, and livelihood benefits. These are: (1) Protect existing forest first; (2) Work together (involving all stakeholders); (3) Aim to maximize biodiversity recovery to meet multiple goals; (4) Select appropriate areas for restoration; (5) Use natural regeneration wherever possible; (6) Select species to maximize biodiversity; (7) Use resilient plant material (with appropriate genetic variability and provenance); (8) Plan ahead for infrastructure, capacity and seed supply; (9) Learn by doing (using an adaptive management approach); and (10) Make it pay (ensuring the economic sustainability of the project).
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