Drawing on more than fifteen years of research,Mexican New Yorkoffers an intimate view of globalization as it is lived by Mexican immigrants and their children in New York and in Mexico. Robert ...Courtney Smith's groundbreaking study sheds new light on transnationalism, vividly illustrating how immigrants move back and forth between New York and their home village in Puebla with considerable ease, borrowing from and contributing to both communities as they forge new gender roles; new strategies of social mobility, race, and even adolescence; and new brands of politics and egalitarianism. Smith's deeply informed narrative describes how first-generation men who have lived in New York for decades become important political leaders in their home villages in Mexico. Smith explains how relations between immigrant men and women and their U.S.-born children are renegotiated in the context of migration to New York and temporary return visits to Mexico. He illustrates how U.S.-born youth keep their attachments to Mexico, and how changes in migration and assimilation have combined to transnationalize both U.S.-born adolescents and Mexican gangs between New York and Puebla.Mexican New Yorkprofoundly deepens our knowledge of immigration as a social process, convincingly showing how some immigrants live and function in two worlds at the same time and how transnationalization and assimilation are not opposing, but related, phenomena.
Diffusion MRI allows the structural connectivity of the whole brain (the ‘tractogram’) to be estimated in vivo non-invasively using streamline tractography. The biological accuracy of these data sets ...is however limited by the inherent biases associated with the reconstruction method. Here we propose a method to retrospectively improve the accuracy of these reconstructions, by selectively filtering out streamlines from the tractogram in a manner that improves the fit between the streamline reconstruction and the underlying diffusion images. This filtering is guided by the results of spherical deconvolution of the diffusion signal, hence the acronym SIFT: spherical-deconvolution informed filtering of tractograms. Data sets processed by this algorithm show a marked reduction in known reconstruction biases, and improved biological plausibility. Emerging methods in diffusion MRI, particularly those that aim to characterise and compare the structural connectivity of the brain, should benefit from the improved accuracy of the reconstruction.
► Novel method for selective filtering of whole-brain fibre-tracking data ► Reduces reconstruction biases of streamline tractography ► Improved biological plausibility of connectome reconstruction ► Better interpretability of structural connectivity between regions
Colorectal cancer statistics, 2023 Siegel, Rebecca L.; Wagle, Nikita Sandeep; Cercek, Andrea ...
CA: a cancer journal for clinicians,
May/June 2023, 2023 May-Jun, 2023-05-00, 20230501, Letnik:
73, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Colorectal cancer (CRC) is the second most common cause of cancer death in the United States. Every 3 years, the American Cancer Society provides an update of CRC statistics based on incidence from ...population‐based cancer registries and mortality from the National Center for Health Statistics. In 2023, approximately 153,020 individuals will be diagnosed with CRC and 52,550 will die from the disease, including 19,550 cases and 3750 deaths in individuals younger than 50 years. The decline in CRC incidence slowed from 3%–4% annually during the 2000s to 1% annually during 2011–2019, driven partly by an increase in individuals younger than 55 years of 1%–2% annually since the mid‐1990s. Consequently, the proportion of cases among those younger than 55 years increased from 11% in 1995 to 20% in 2019. Incidence since circa 2010 increased in those younger than 65 years for regional‐stage disease by about 2%–3% annually and for distant‐stage disease by 0.5%–3% annually, reversing the overall shift to earlier stage diagnosis that occurred during 1995 through 2005. For example, 60% of all new cases were advanced in 2019 versus 52% in the mid‐2000s and 57% in 1995, before widespread screening. There is also a shift to left‐sided tumors, with the proportion of rectal cancer increasing from 27% in 1995 to 31% in 2019. CRC mortality declined by 2% annually from 2011–2020 overall but increased by 0.5%–3% annually in individuals younger than 50 years and in Native Americans younger than 65 years. In summary, despite continued overall declines, CRC is rapidly shifting to diagnosis at a younger age, at a more advanced stage, and in the left colon/rectum. Progress against CRC could be accelerated by uncovering the etiology of rising incidence in generations born since 1950 and increasing access to high‐quality screening and treatment among all populations, especially Native Americans.
This paper makes a plea for more reflexive attempts to develop and anchor the emerging concept of responsible research and innovation (RRI). RRI has recently emerged as a buzzword in science policy, ...becoming a focus of concerted experimentation in many academic circles. Its performative capacity means that it is able to mobilise resources and spaces despite no common understanding of what it is or should be ‘made of’. In order to support reflection and practice amongst those who are interested in and using the concept, this paper unpacks understandings of RRI across a multi-disciplinary body of peer-reviewed literature. Our analysis focuses on three key dimensions of RRI (motivations, theoretical conceptualisations and translations into practice) that remain particularly opaque. A total of 48 publications were selected through a systematic literature search and their content was qualitatively analysed. Across the literature, RRI is portrayed as a concept that embeds numerous features of existing approaches to govern and assess emerging technologies. Our analysis suggests that its greatest potential may be in its ability to unify and provide political momentum to a wide range of long-articulated ethical and policy issues. At the same time, RRI’s dynamism and resulting complexity may represent its greatest challenge. Further clarification on what RRI has to offer in practice—beyond what has been offered to date—is still needed, as well as more explicit engagement with research and institutional cultures of responsibility. Such work may help to realise the high political expectations that are attached to nascent RRI.
Quantum atomic and molecular gases are flexible systems for studies of fundamental many-body physics. They have traditionally been produced in harmonic electromagnetic traps and thus had ...inhomogeneous densities, but recent advances in light shaping for optical trapping of neutral particles have led to the development of flat-bottomed optical box traps, allowing the creation of homogeneous samples. Box trapping simplifies the interpretation of experimental results, provides more direct connections with theory and, in some cases, allows qualitatively new, hitherto impossible experiments. It has now been achieved for both Bose and Fermi atomic gases in various dimensionalities, and also for gases of heteronuclear molecules. Here we review these developments and the consequent breakthroughs in the study of both equilibrium and non-equilibrium phenomena such as superfluidity, turbulence and the dynamics of phase transitions.Optical box traps create a potential landscape for quantum gases that is close to the homogeneous theoretical ideal. This Review of box trapping methods highlights the breakthroughs in experimental many-body physics that have followed their development.
A central concept in the modern understanding of turbulence is the existence of cascades of excitations from large to small length scales, or vice versa. This concept was introduced in 1941 by ...Kolmogorov and Obukhov, and such cascades have since been observed in various systems, including interplanetary plasmas, supernovae, ocean waves and financial markets. Despite much progress, a quantitative understanding of turbulence remains a challenge, owing to the interplay between many length scales that makes theoretical simulations of realistic experimental conditions difficult. Here we observe the emergence of a turbulent cascade in a weakly interacting homogeneous Bose gas-a quantum fluid that can be theoretically described on all relevant length scales. We prepare a Bose-Einstein condensate in an optical box, drive it out of equilibrium with an oscillating force that pumps energy into the system at the largest length scale, study its nonlinear response to the periodic drive, and observe a gradual development of a cascade characterized by an isotropic power-law distribution in momentum space. We numerically model our experiments using the Gross-Pitaevskii equation and find excellent agreement with the measurements. Our experiments establish the uniform Bose gas as a promising new medium for investigating many aspects of turbulence, including the interplay between vortex and wave turbulence, and the relative importance of quantum and classical effects.
This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and ...impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1979.
Diffusion MRI streamlines tractography allows for the investigation of the brain white matter pathways non-invasively. However a fundamental limitation of this technology is its non-quantitative ...nature, i.e. the density of reconstructed connections is not reflective of the density of underlying white matter fibres. As a solution to this problem, we have previously published the “spherical-deconvolution informed filtering of tractograms (SIFT)” method, which determines a subset of the streamlines reconstruction such that the streamlines densities throughout the white matter are as close as possible to fibre densities estimated using the spherical deconvolution diffusion model; this permits the use of streamline count as a valid biological marker of connection density. Particular aspects of its performance may have however limited its uptake in the diffusion MRI research community. Here we present an alternative to this method, entitled SIFT2, which provides a more logically direct and computationally efficient solution to the streamlines connectivity quantification problem: by determining an appropriate cross-sectional area multiplier for each streamline rather than removing streamlines altogether, biologically accurate measures of fibre connectivity are obtained whilst making use of the complete streamlines reconstruction.
•Follow-up to the “spherical-deconvolution informed filtering of tractograms” method•Imbues tractograms with quantitative properties by assigning weights to streamlines•Utilizes all input streamlines for high-density connectivity solutions
The human gut microbiome can influence health through the brain-gut-microbiome axis. Growing evidence suggests that the gut microbiome can influence sleep quality. Previous studies that have examined ...sleep deprivation and the human gut microbiome have yielded conflicting results. A recent study found that sleep deprivation leads to changes in gut microbiome composition while a different study found that sleep deprivation does not lead to changes in gut microbiome. Accordingly, the relationship between sleep physiology and the gut microbiome remains unclear. To address this uncertainty, we used actigraphy to quantify sleep measures coupled with gut microbiome sampling to determine how the gut microbiome correlates with various measures of sleep physiology. We measured immune system biomarkers and carried out a neurobehavioral assessment as these variables might modify the relationship between sleep and gut microbiome composition. We found that total microbiome diversity was positively correlated with increased sleep efficiency and total sleep time, and was negatively correlated with wake after sleep onset. We found positive correlations between total microbiome diversity and interleukin-6, a cytokine previously noted for its effects on sleep. Analysis of microbiome composition revealed that within phyla richness of Bacteroidetes and Firmicutes were positively correlated with sleep efficiency, interleukin-6 concentrations and abstract thinking. Finally, we found that several taxa (Lachnospiraceae, Corynebacterium, and Blautia) were negatively correlated with sleep measures. Our findings initiate linkages between gut microbiome composition, sleep physiology, the immune system and cognition. They may lead to mechanisms to improve sleep through the manipulation of the gut microbiome.
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