The ATLAS experiment at the LHC at CERN will move to use the Front-End Link eXchange (FELIX) system in a staged approach for LHC Run 3 (2021) and LHC Run 4 (2026). FELIX will act as the interface ...between the data acquisition; detector control and TTC (Timing, Trigger and Control) systems; and new or updated trigger and detector front-end electronics. FELIX functions as a router between custom serial links from front end ASICs and FPGAs to data collection and processing components via a commodity switched network. Links may aggregate many slower links or be a single high bandwidth link. FELIX also forwards the LHC bunch-crossing clock, fixed latency trigger accepts and resets received from the TTC system to front-end electronics. The FELIX system uses commodity server technology in combination with FPGA-based PCIe I/O cards. The FELIX servers run a software routing platform serving data to network clients. Commodity servers connected to FELIX systems via the same network run innovative multi-threaded software for event fragment building, processing, buffering and forwarding. This proceeding will describe the design and status of the FELIX based readout for the Run 3 upgrade, during which a subset of the detector will be migrated. It will also show how the same concept has been successfully introduced into the demonstrator test bench of the ATLAS Pixel Inner Tracker, acting as a proof of concept towards the longer term Run 4 upgrade in which all detectors will adopt a FELIX based readout.
MALTA2 is a depleted monolithic active pixel sensor (DMAPS) developed in the Tower 180 nm CMOS imaging process. Monolithic CMOS sensors offer advantages over current hybrid imaging sensors both in ...terms of increased tracking performance due to lower material budget but also in terms of ease of integration and construction costs due to the monolithic design. Current research and development efforts are aimed towards radiation-hard designs up to 100 Mrad in Total Ionizing Dose and 3×1015 1 MeV neq/cm2 in Non-Ionizing Energy Loss. One important property of a sensor’s radiation hardness is the depletion depth at which efficient charge collection is achieved via drift movement. Grazing angle test-beam data was taken during the 2023 SPS CERN test beam with the MALTA telescope and Edge Transient Current Technique studies were performed at DESY in order to develop a quantitative study of the depletion depth for un-irradiated, epitaxial MALTA2 samples. The study is planned to be extended for irradiated and Czochralski MALTA2 samples.
MALTA is a depleted monolithic active pixel sensor (DMAPS) developed in the Tower Semiconductor 180-nm CMOS imaging process. Monolithic CMOS sensors offer advantages over current hybrid imaging ...sensors in terms of both increased tracking performance due to lower material budget and ease of integration and construction costs due to the integration of read-out and active sensor into one ASIC. Current research and development efforts are aimed toward radiation hard designs up to 100 Mrad in total ionizing dose (TID) and <inline-formula> <tex-math notation="LaTeX">1\,\, \times 10 ^{15}~1~\text {MeV}\text {n}_{\text {eq}}/\text {cm}^{2} </tex-math></inline-formula> in nonionizing energy loss (NIEL). The design of the MALTA sensors was specifically chosen to achieve radiation hardness up to these requirements and satisfy current and future collider constraints. The current MALTA pixel architecture uses small electrodes which provide less noise, higher signal voltage, and a better power-to-performance ratio. To counteract the loss of efficiency in pixel corners, modifications to the Tower process have been implemented. The MALTA sensors have been tested during the 2021 and 2022 SPS CERN Test Beam in the MALTA telescope. The telescope ran for the whole duration of the beam time and took data to characterize the novel MALTA2 variant and the performance of irradiated samples in terms of efficiency and cluster size. These campaigns show that MALTA is an interesting prospect for HL-LHC and beyond collider experiments, providing both very good tracking capabilities and radiation hardness in harsh radiation environments.
The MALTA pixel chip is a 2 cm × 2 cm large monolithic pixel detector developed in the Tower 180 nm imaging process. The chip contains four CMOS transceiver blocks at its sides which allow ...chip-to-chip data transfer. The power pads are located mainly at the side edges on the chip which allows for chip-to-chip power transmission. The MALTA chip has been used to study module assembly using different interconnection techniques to transmit data and power from chip to chip and to minimize the overall material budget. Several 2-chip and 4-chip modules have been assembled using standard wire bonding, ACF (Anisotropic Conductive Films) and laser reflow interconnection techniques. These proceedings will summarize the experience with the different interconnection techniques and performance tests of MALTA modules with 2 and 4 chips tested in a cosmic muon telescope. They will also show first results on the effect of serial power tests on chip performance as well as the impact of the different interconnection techniques and the results of mechanical tests. Finally, a conceptual study for a flex based ultra-light weight monolithic pixel module based on the MALTA chip with minimum interconnections is presented.
Measurement results of the MALTA monolithic pixel detector Schioppa, E.J.; Asensi Tortajada, I.; Berdalovic, I. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2020, Letnik:
958
Journal Article
Recenzirano
MALTA is a full scale monolithic pixel detector implemented in TowerJazz 180 nm CMOS technology. The small pixel electrode allowed for the implementation of a fast, low noise and low power front-end, ...which is sensitive to the charge released by ionizing radiation in a 20–25 μm deep depleted region. The novel asynchronous matrix architecture is designed to ensure low power consumption and high rate capability. Such features make MALTA a possible candidate for the outer layer of ATLAS Inner Tracker (ITk) upgrade. Unirradiated and irradiated MALTA sensors have been extensively tested in laboratory and with high energy particle beams. Results of this measurements campaign are shown, and the further improvements that are being implemented in the next versions of the chip are discussed.
Clofazimine is recommended for the treatment of rifampicin-resistant tuberculosis (RR-TB), but there is currently no verified dosing guideline for its use in children. There is only limited safety ...and no pharmacokinetic (PK) data available for children. We aimed to characterize clofazimine PK and its relationship with QT-interval prolongation in children. An observational cohort study of South African children <18 years old routinely treated for RR-TB with a clofazimine-containing regimen was analyzed. Clofazimine 100 mg gelatin capsules were given orally once daily (≥20 kg body weight), every second day (10 to <20 kg), or thrice weekly (<10 kg). PK sampling and electrocardiograms were completed pre-dose and at 1, 4, and 10 hours post-dose, and the population PK and Fridericia-corrected QT (QTcF) interval prolongation were characterized. Fifty-four children contributed both PK and QTcF data, with a median age (2.5th-97.5th centiles) of 3.3 (0.5-15.6) years; five children were living with HIV. Weekly area under the time-concentration curve at steady state was 79.1 (15.0-271) mg.h/L compared to an adult target of 60.9 (56.0-66.6) mg.h/L. Children living with HIV had four times higher clearance compared to those without. No child had a QTcF ≥500 ms. A linear concentration-QTcF relationship was found, with a drug effect of 0.05 (0.027, 0.075) ms/µg/L. In some of the first PK data in children, we found clofazimine exposure using an off-label dosing strategy was higher in children versus adults. Clofazimine concentrations were associated with an increase in QTcF, but severe prolongation was not observed. More data are required to inform dosing strategies in children.
The aim of this study was to investigate the role of the TLR8, a mediator of innate inflammatory response, in susceptibility to two immune-mediated disorders characterised by dysregulation of the ...immune response, Crohn's and Behçet's diseases (CD and BD).
A total of 844 CD, 371 BD patients and 1385 controls were genotyped in 8 tag single nucleotide polymorphisms (tSNPs) in the locus TLR8 (chromosome X). All these tSNPs have a minor allele frequency greater than 0.05 in the Caucasian population.
The rs2407992 and the rs5744067 were associated with susceptibility to BD and CD, respectively (OR=1.34, 95%CI=1.10-1.62, p=0.0025 and OR=0.82, 95%CI=0.68-0.99, p=0.045, respectively). Although after stratification by gender, statistically significant differences in the distribution of the aforementioned SNPs were only observed in the females groups (BD OR=1.31, 95%CI=1.06-1.64, p=0.012 and CD OR=0.84, 95%CI=0.72-0.98, p=0.044) the trend was similar among males. Since the rs5744067 and rs2407992 are located in the same linkage disequilibrium block, we performed a haplotypic analysis by combination of the tSNPs. One haplotype (H1) was identified as a protective factor in BD (OR=0.75, 95%CI=0.62-0.90, p=0.0027) and another (H2) as a protective factor in CD (OR=0.78, 95%CI=0.64-094, p=0.0102). No statistically significant differences in the mean of the levels of expression attributable to the haplotype variants were found in the in silico analysis performed.
Our results suggest a relationship between the TLR8 and the susceptibility to CD and BD. Nevertheless, these differences could not be imputed to the levels of expression.
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