Superconductivity arises from two distinct quantum phenomena: electron pairing and long-range phase coherence. In conventional superconductors, the two quantum phenomena generally take place ...simultaneously, while in the underdoped high- Tc cuprate superconductors, the electron pairing occurs at higher temperature than the long-range phase coherence. Recently, whether electron pairing is also prior to long-range phase coherence in single-layer FeSe film on SrTiO3 substrate is under debate. Here, by measuring Knight shift and nuclear spin-lattice relaxation rate, we unambiguously reveal a pseudogap behavior below Tp∼60 K in two kinds of layered FeSe-based superconductors with quasi2D nature. In the pseudogap regime, a weak diamagnetic signal and a remarkable Nernst effect are also observed, which indicates that the observed pseudogap behavior is related to superconducting fluctuations. These works confirm that strong phase fluctuation is an important character in the 2D iron-based superconductors as widely observed in high-Tc cuprate superconductors.
•Mesoporous rare-earth orthoferrite (GdFeO3) nanostructures were prepared by a facile one-step hydrothermal process.•Structural effects of GdFeO3 nanostructure on NOx gas-response properties were ...systematically investigated.•Mesosphere-like GdFeO3 nanostructure exhibited the best gas-response characteristics to nitric oxide (NO) at 140 °C.•NO gas-response mechanism of GdFeO3 nanostructure was discussed.
Gas sensing characteristics of rare-earth-based orthoferrite (GdFeO3) mesoporous nanostructures were prepared by a facile one-step hydrothermal process. The structural analyses of the obtained materials showed sphere, leaf and flower-like nanostructured architectures. Further, the chemiresistive gas-response properties of the GdFeO3 nanostructure were investigated with various combustible gases, such as nitric oxide (NO), nitrogen dioxide (NO2), carbon monoxide (CO), ammonia (NH3), hydrogen sulfide (H2S), formaldehyde (HCHO), ethanol (C2H5OH) and gasoline, at different operating temperatures. The sphere-like GdFeO3 nanostructure shows a significantly high resistance variation to NO compared with the other architectures, exhibits a high response (91%) when exposed to 100 ppm NO, and detects a level as low as 2 ppm (7%) at an optimum operating temperature of 140 °C. The GdFeO3 nanostructure shows an excellent stability and repeatability after successive repeated cycles with a fast response and recovery time when exposed to 100 ppm NO gas. The superior response and excellent selectivity of the perovskite GdFeO3 nanostructure are due to its higher catalytic activity, large surface area, oxygen deficiency, mesoporosity, and peculiar morphology. The response mechanism of NO on the GdFeO3 nanostructured surface is also discussed in detail.
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients, and is characterized by progressive loss of articular cartilage that eventually leads to a ...complex process involving degradation of various components of the cartilage matrix, chief among them are the cartilage-specific type II collagen (CII) and aggrecan. While the loss of aggrecan is thought to be an early and reversible process, degradation of CII is considered to be irreversible and a key step in the loss of structural and functional integrity of cartilage. Among the various matrix metalloproteinases (MMPs), MMP-13 is specifically expressed in the cartilage of human OA patients and is not present in normal adult cartilage. It is the major collagenase in OA cartilage and has the highest activity against CII. However, the clinical utility of broad-spectrum MMP inhibitors developed for treatment of OA has been restricted by dose- and duration-dependent musculoskeletal side effects in humans. Consequently, selectively inhibiting the MMP-13 would seem to be an attractive therapeutic objective. This review mainly focuses on selective MMP-13 inhibitors development in terms of OA since the late 90s, in terms of synthetic compounds of low molecular mass incorporating specific zinc-binding groups, non-zinc-binding groups. In addition, dual inhibitors of MMP-13 and aggrecanase are also reviewed. Special emphasis is placed on logistic concerns for lead compound search as well as the structure-activity relationship (SAR) in this field. Through these methods, new hope is emerging for the treatment of OA through selective inhibition of MMP-13.
The importance of the spin-orbit coupling (SOC) effect in Fe-based superconductors (FeSCs) has recently been under hot debate. Considering the Hund’s coupling-induced electronic correlation, the ...understanding of the role of SOC in FeSCs is not trivial and is still elusive. Here, through a comprehensive study ofSe77andFe57nuclear magnetic resonance, a nontrivial SOC effect is revealed in the nematic state of FeSe. First, the orbital-dependent spin susceptibility, determined by the anisotropy of theFe57Knight shift, indicates a predominant role from the3dxyorbital, which suggests the coexistence of local and itinerant spin degrees of freedom in the FeSe. Then, we reconfirm that the orbital reconstruction below the nematic transition temperature (Tnem∼90K) happens not only on the3dxzand3dyzorbitals but also on the3dxyorbital, which is beyond a trivial ferro-orbital order picture. Moreover, our results also indicate the development of a coherent coupling between the local and itinerant spin degrees of freedom belowTnem, which is ascribed to a Hund’s coupling-induced electronic crossover on the3dxyorbital. Finally, because of a nontrivial SOC effect, sizable in-plane anisotropy of the spin susceptibility emerges in the nematic state, suggesting a spin-orbital-intertwined nematicity rather than a simple spin- or orbital-driven nematicity. The present work not only reveals a nontrivial SOC effect in the nematic state but also sheds light on the mechanism of nematic transition in FeSe.
The limitations of cancer cell lines have led to the development of direct patient-derived xenograft models. However, the interplay between the implanted human cancer cells and recruited mouse ...stromal and immune cells alters the tumor microenvironment and limits the value of these models. To overcome these constraints, we have developed a technique to expand human hematopoietic stem and progenitor cells (HSPCs) and use them to reconstitute the radiation-depleted bone marrow of a NOD/SCID/IL2rg(-/-) (NSG) mouse on which a patient's tumor is then transplanted (XactMice). The human HSPCs produce immune cells that home into the tumor and help replicate its natural microenvironment. Despite previous passage on nude mice, the expression of epithelial, stromal and immune genes in XactMice tumors aligns more closely to that of the patient tumor than to those grown in non-humanized mice-an effect partially facilitated by human cytokines expressed by both the HSPC progeny and the tumor cells. The human immune and stromal cells produced in the XactMice can help recapitulate the microenvironment of an implanted xenograft, reverse the initial genetic drift seen after passage on non-humanized mice and provide a more accurate tumor model to guide patient treatment.
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium ...(PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.
The diffusion of hydrogen in austenite is slower than in ferrite. Experiments have been conducted to study the behaviour of hydrogen in a nanostructured steel sample consisting of a mixture of thin ...plates of bainitic ferrite and intervening films of retained austenite, with the latter phase present in a quantity larger than the percolation threshold, i.e. it has three-dimensional connectivity. The structure was then heat treated to control the fraction of austenite, and hence to study the role of hydrogen when the austenite decomposes below the value required to sustain percolation. The experiments have involved both thermal desorption analysis and permeation, and when combined with theoretical analysis, indicate a significant influence of percolating austenite in hindering the passage of hydrogen into the steel during hydrogen charging, and its permeation through the composite nanostructure. The effect is not as large as might be expected from a simple comparison of independent data on the diffusivities of hydrogen in the two lattices, because the effective diffusivity in ferrite is found to be much smaller than in the defect-free ferrite, owing to trapping effects. The morphology of the austenite is demonstrated to play a role by comparing with a sample containing a larger volume fraction of austenite but present as isolated grains which are ineffective to the permeation of hydrogen.
Aerosol‐planetary boundary layer (PBL) interactions have been found to enhance air pollution in megacities in China. We show that black carbon (BC) aerosols play the key role in modifying the PBL ...meteorology and hence enhancing the haze pollution. With model simulations and data analysis from various field observations in December 2013, we demonstrate that BC induces heating in the PBL, particularly in the upper PBL, and the resulting decreased surface heat flux substantially depresses the development of PBL and consequently enhances the occurrences of extreme haze pollution episodes. We define this process as the “dome effect” of BC and suggest an urgent need for reducing BC emissions as an efficient way to mitigate the extreme haze pollution in megacities of China.
Key Points
BC plays an important role in enhancing surface haze pollution in megacities in China
Upper PBL heating and surface cooling by BC are two comparable processes in the PBL feedback
Reducing BC emission cobenefits the mitigations of haze pollution and global warming
In this study, microstructure and mechanical behavior of Co-free Ni2CrFeAl0.3Tix high-entropy alloys are investigated. X-ray diffraction analysis show that a simple face-centered cubic (FCC) ...solid-solution structure is present in Ni2CrFeAl0.3Ti0.1 and Ni2CrFeAl0.3Ti0.2 alloys, while B2-type precipitation appears in Ni2CrFeAl0.3Ti0.3 alloy in addition to the FCC matrix. Tensile results reveal that with an increase in Ti content, the yield and tensile strength of the alloys increases while the ductility decreases, and fortunately a good balance between strength and ductility is attained in Ni2CrFeAl0.3Ti0.3 that exhibits an ultimate tensile strength of 1240 MPa combined with over 10 % fracture strain. This feature can be ascribed to the visible strain-hardening response, reduced stacking-fault energy (ranging from 56.5 to 37.4 mJ∙m−2) and very fine B2 precipitates due to Ti addition. This work would provide an insight into the design of low-cost Ti-containing alloys in the future.
•A novel Co-free Ni2CrFeAl0.3Tix alloy system is investigated.•A good balance of strength and ductility is attained in Ni2CrFeAl0.3Ti0.3 alloy.•The addition of Ti yields reduced SFE values ranging from 56.5 to 37.4 mJ∙m−2.•Fine B2 precipitation plus FCC phase constitute a eutectic-type structure.