Out-of-hospital cardiac arrest (OHCA) is a leading cause of global mortality. Regional variations in reporting frameworks and survival mean the exact burden of OHCA to public health is unknown. ...Nevertheless, overall prognosis and neurological outcome are relatively poor following OHCA and have remained almost static for the past three decades. In this Series paper, we explore the aetiology of OHCA. Coronary artery disease remains the predominant cause, but there is a diverse range of other potential cardiac and non-cardiac causes to be aware of. Additionally, we describe how investigators and key stakeholders in resuscitation science have formulated specific Utstein data element domains in an attempt to standardise the definitions and outcomes reported in OHCA research so that management pathways can be improved. Finally, we identify the predictors of survival after OHCA and what primary and secondary prevention strategies can be instigated to mitigate the devastating sequelae of this growing public health issue.
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous ...metabolite itaconate has been reported to regulate macrophage function, but its precise mechanism is not clear. Here, we show that 4-octyl itaconate (4-OI, a cell-permeable itaconate derivative) directly alkylates cysteine residue 22 on the glycolytic enzyme GAPDH and decreases its enzyme activity. Glycolytic flux analysis by U
C glucose tracing provides evidence that 4-OI blocks glycolytic flux at GAPDH. 4-OI thereby downregulates aerobic glycolysis in activated macrophages, which is required for its anti-inflammatory effects. The anti-inflammatory effects of 4-OI are replicated by heptelidic acid, 2-DG and reversed by increasing wild-type (but not C22A mutant) GAPDH expression. 4-OI protects against lipopolysaccharide-induced lethality in vivo and inhibits cytokine release. These findings show that 4-OI has anti-inflammatory effects by targeting GAPDH to decrease aerobic glycolysis in macrophages.
The development of fluorophores and molecular probes for the second near-infrared biological window (NIR-II, 1000-1700 nm) represents an important, newly emerging and dynamic field in molecular ...imaging, chemical biology and materials chemistry. Because of reduced scattering, minimal absorption and negligible autofluorescence, NIR-II imaging provides high resolution, a high signal-to-noise ratio, and deep tissue penetration capability. Among various state-of-the-art bioimaging modalities, one of the greatest challenges in developing novel probes is to achieve both high resolution and sensitivity. The chemical design and synthesis of NIR-II fluorophores suitable for multimodal imaging is thus emerging as a new and powerful strategy for obtaining high-definition images. NIR-II fluorophores may convert NIR-II photons into heat for photothermal therapy and be excited by NIR-II light to produce singlet oxygen for photodynamic therapy. The presence of simultaneous diagnostic and therapeutic capabilities in a single probe can be used for precise treatment. In this review, we have focused on recent advances in the chemical design and synthesis of NIR-II fluorophores from small organic molecules to organic and inorganic nanoparticles, and we have further discussed recent advances and key operational differences in reported NIR-II imaging systems and biomedical applications based on NIR-II imaging, such as multimodal imaging, photothermal and photodynamic therapy, guidance for intraoperative surgery, and drug delivery.
An interactive human‐machine interface (iHMI) enables humans to control hardware and collect feedback information. In particular, wearable iHMI systems have attracted tremendous attention owing to ...their potential for use in personal mobile electronics and the Internet of Things. Although significant progress has been made in the development of iHMI systems, those based on rigid electronics have constraints in terms of wearability, comfortability, signal‐to‐noise ratio (SNR), and aesthetics. Herein the fabrication of a transparent and stretchable iHMI system composed of wearable mechanical sensors and stimulators is reported. The ultrathin and lightweight design of the system allows superior wearability and high SNR. The use of conductive/piezoelectric graphene heterostructures, which consist of poly(l‐lactic acid), single‐walled carbon nanotubes, and silver nanowires, results in high transparency, excellent performance, and low power consumption as well as mechanical deformability. The control of a robot arm for various motions and the feedback stimulation upon successful executions of commands are demonstrated using the wearable iHMI system.
A transparent and stretchable interactive human machine interface (iHMI) based on patterned graphene (GP) heterostructures is developed. The conductive/piezoelectric GP heterostructures enable the iHMI to have high transparency, excellent performance, low power consumption, and superb mechanical deformability. The control of a robot arm for various motions and feedback stimulation upon successful executions of commands are demonstrated using the wearable iHMI system.
Tin‐based compounds have received much attention as anode materials for lithium/sodium ion batteries owing to their high theoretical capacity. However, the huge volume change usually leads to the ...pulverization of electrode, giving rise to a poor cycle performance, which have severely hampered their practical application. Herein, highly durable yolk–shell SnSe2 nanospheres (SnSe2@SeC) are prepared by a multistep templating method, with an in situ gas‐phase selenization of the SnO2@C hollow nanospheres. During this process, Se can be doped into the carbon shell with a tunable amount and form SeC bonds. Density functional theory calculation results reveal that the SeC bonding can enhance the charge transfer properties as well as the binding interaction between the SnSe2 core and the carbon shell, favoring an improved rate performance and a superior cyclability. As expected, the sample delivers reversible capacities of 441 and 406 mAh g−1 after 2000 cycles at 2 and 5 A g−1, respectively, as the anode material for a sodium‐ion battery. Such performances are significantly better than the control sample without the SeC bonding and also other metal selenide‐based anodes, evidently showing the advantage of Se doping in the carbon shell.
Yolk–shell SnSe2@C nanospheres with SeC bonds in the carbon shell are synthesized by selenization of the SnO2@C precursor. Density functional theory calculation results reveal that the SeC bonding can enhance the charge transfer properties and the binding energy between the SnSe2 core and the carbon shell, leading to greatly improved high‐rate performance and cycling stability for a sodium‐ion battery.
The chemists’ pursuit of the ideal synthesis and functionalization of indole derivatives has lasted over 150 years as their scaffolds have been widely found in natural products, pharmaceuticals, ...agrochemicals and organic materials. In this regard, the recent resurgence of adopting green and sustainable electrochemistry in organic synthesis suggests that electrosynthesis is a promising strategy. Indeed, many new intriguing applications of synthesis and functionalization of indole derivatives by direct and redox‐mediated electrochemical means have been disclosed. In this review, we highlight the fundamental aspects, reaction scopes, synthetic applications and reaction mechanisms of the electrochemical synthesis and functionalization of indole derivatives.
Emerging ionic liquid lubricants were discovered only 20 years ago. The superior performance of ionic liquids over traditional lubricating fluids have been reviewed, including low-temperature ...fluidity, viscosity–temperature properties, thermal oxidation stability, ultralow volatility, incompressibility, electrical conductivity, friction coefficient under elastohydrodynamic lubrication conditions, friction reduction and antiwear performance under boundary lubrication conditions, environmental friendliness, etc. The applications where ionic liquids are superior to traditional lubricant fluids are presented, including hydrogen compressor lubricating fluids and liquid pistons, oxygen compressor lubricating fluids, hydraulic fluids, space lubricants, vehicle engine oils, industrial gear oils, metalworking fluids, industrial coolant, micro/nano electromechanical system applications, electrical conductive lubricants, etc. The ability of ionic liquids to replace ZDDP, a key additive of lubricating oil, is introduced. The future development prospects of ionic liquid lubricants are analyzed.
With the fast development of industrial Internet of things (IIoT), a large amount of data is being generated continuously by different sources. Storing all the raw data in the IIoT devices locally is ...unwise considering that the end devices' energy and storage spaces are strictly limited. In addition, the devices are unreliable and vulnerable to many threats because the networks may be deployed in remote and unattended areas. In this paper, we discuss the emerging challenges in the aspects of data processing, secure data storage, efficient data retrieval and dynamic data collection in IIoT. Then, we design a flexible and economical framework to solve the problems above by integrating the fog computing and cloud computing. Based on the time latency requirements, the collected data are processed and stored by the edge server or the cloud server. Specifically, all the raw data are first preprocessed by the edge server and then the time-sensitive data (e.g., control information) are used and stored locally. The non-time-sensitive data (e.g., monitored data) are transmitted to the cloud server to support data retrieval and mining in the future. A series of experiments and simulation are conducted to evaluate the performance of our scheme. The results illustrate that the proposed framework can greatly improve the efficiency and security of data storage and retrieval in IIoT.
The development of new electrode materials for lithium‐ion batteries (LIBs) has always been a focal area of materials science, as the current technology may not be able to meet the high energy ...demands for electronic devices with better performance. Among all the metal oxides, tin dioxide (SnO2) is regarded as a promising candidate to serve as the anode material for LIBs due to its high theoretical capacity. Here, a thorough survey is provided of the synthesis of SnO2‐based nanomaterials with various structures and chemical compositions, and their application as negative electrodes for LIBs. It covers SnO2 with different morphologies ranging from 1D nanorods/nanowires/nanotubes, to 2D nanosheets, to 3D hollow nanostructures. Nanocomposites consisting of SnO2 and different carbonaceous supports, e.g., amorphous carbon, carbon nanotubes, graphene, are also investigated. The use of Sn‐based nanomaterials as the anode material for LIBs will be briefly discussed as well. The aim of this review is to provide an in‐depth and rational understanding such that the electrochemical properties of SnO2‐based anodes can be effectively enhanced by making proper nanostructures with optimized chemical composition. By focusing on SnO2, the hope is that such concepts and strategies can be extended to other potential metal oxides, such as titanium dioxide or iron oxides, thus shedding some light on the future development of high‐performance metal‐oxide based negative electrodes for LIBs.
Tin dioxide (SnO2) is an attractive candidate as a high‐capacity anode material for lithium‐ion batteries. In this review, a comprehensive discussion is provided about the synthesis of both phase‐pure SnO2 and SnO2‐based nanocomposites with different nanostructures ranging from 1D nanorods, to 2D nanosheets, to 3D hollow structures, and their application in high‐performance lithium‐ion batteries is discussed.
This review (with 145 refs.) summarizes the progress that has been made in the use of zeolitic imidazolate frameworks in chemical sensing and biosensing. Zeolitic imidazolate frameworks (ZIFs) are a ...type of porous material with zeolite topological structure that combine the advantages of zeolite and traditional metal–organic frameworks. Owing to the structural flexibility of ZIFs, their pore sizes and surface functionalization can be reasonably designed. Following an introduction into the field of metal–organic frameworks and the zeolitic imidazolate framework (ZIF) subclass, a first large section covers the various kinds and properties of ZIFs. The next large section covers electrochemical sensors and assays (with subsections on methods for gases, electrochemiluminescence, electrochemical biomolecules). This is followed by main sections on ZIF-based colorimetric and luminescent sensors, with subsections on sensors for metal ions and anions, for gases, and for organic biomolecules. The last section covers SERS-based assays. Several tables are presented that give an overview on the wealth of methods and materials. A concluding section summarizes the current status, addresses current challenges, and gives an outlook on potential future trends.
Graphical abstract
In recent years, ZIFs and their composites have been widely used as probes in chemical sensing, and these probes have shown great advantages over other materials. This review describes the current progress on ZIFs toward electrochemical, luminescence, colorimetric, and SERS-based sensing applications, highlighting the different strategies for designing ZIFs and their composites and potential challenges in this field.
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