Display omitted
•Betaxanthin reduces metabolic dysfunction in postmenopausal mouse models.•Betaxanthin decreases lung tumor growth in postmenopausal mouse models Betaxanthin mitigates pre-existing ...lung tumor growth in postmenopausal obese mouse model.•Betaxanthin inhibits lung cancer cell proliferation and migration in response to insulin challenge.•Betaxanthin suppresses tumor growth in the setting of hyperinsulinemia.•Betaxanthin improves SIRT3 expression levels in the lung tumor.
Metabolic disturbances associated with obesity increase the risk and advancement of various tumor forms, including postmenopausal lung cancer, in humans. Betaxanthin, a type of yellow-orange pigment found in certain plants, particularly in some flowers, fruits, and vegetables, can be utilized to inhibit the growth of tumors and lessen the metabolic dysfunctions brought on by obesity. However, the functional role of betaxanthin (BET) in suppressing lung cancer progression and its potential mechanisms are still not fully understood. In this study, we examined the regulation of BET in obese mice with postmenopausal lung cancer receiving a high-fat diet (HFD). Initially, we found that BET could significantly mitigate the metabolic dysfunction that a high-fat diet causes in mice. Improved histological changes in the mammary fat pad, lower hepatic lipid deposition, and improved glucose tolerance and insulin resistance demonstrated this. Following that, BET treatment inhibited the formation of lung neoplasms in in-situ cancer animal models that were stimulated by HFD. Furthermore, in a postmenopausal mouse model fed HFD, BET significantly reduced the growth of pre-existing lung tumors, as well as attenuating metabolic abnormalities. Notably, in vitro research revealed that BET co-culture significantly reduced the proliferation and migration of mouse lung cancer cells, whereas insulin exposure increased these processes. Research on animals verified that lung cancer progressed due to hyperinsulinemia; however, BET treatment might inhibit this condition in postmenopausal mice on a high-fat diet. BET could up-regulate sirtuin 3 (SIRT3) expression levels in tumor, liver, and mammary fat pad tissues in postmenopausal mice with HFD-induced obesity, according to a bioinformatic and molecular biology study. Crucially, eradicating SIRT3 expression completely eliminated BET’s inhibitory effects on insulin-stimulated cancer cell proliferation and migration. This suggests that increasing SIRT3 expression may be required for BET to perform its anti-tumor function against lung cancer in conditions of hyperinsulinemia. Our findings showed that by modifying SIRT3 signaling, BET consumption is probably effective in the prevention and treatment of obesity-related lung cancer.
Web-based enterprises have increasingly begun to build their own virtual brand community on the Cloud. How to encourage Web users to generate Web content in the Web community continuously and ...permanently has become the focal point. However, few studies have explored that how to drive the motivation of user-generated content (UGC) named self-enhancement (SE) internalized from the perspective of user’s personal characteristics and then enhance the intention of UGC. Even fewer studies have been devoted to drive the motivation of UGC from the perspective of information technology. Based on self-construal (SC) theory, self-determination (SD) theory, and current immersive applications of Edge computing, we proposed to a solution of user-generated content motivation internalized in the virtual brand community implemented through the manipulation of the tradeoff of inter-Edge and Cloud processing. Our survey shows that different types of self-construal (SC) users have different levels of internal motivation for self-enhancement (SE) accomplished through the organization of user characteristics. We build a detailed simulation of the change of time delay, availability, and cost of inter-Edge and Cloud conversion to demonstrate the feasibility of our proposed mechanism of UGC motivation internalized in the virtual brand community in guiding enhancing the intention of UGC in the community in practice.
Electrode erosion has become a bottleneck problem restricting the development and application of gas switch. In this paper, a two-dimensional model of interaction between plasma and metal cathode has ...been developed to describe the electrode erosion process in high power gas spark switch. The model both considers electrode heating process and electrode material removal process by using the volume-of-fluid (VOF) method. The simulation results show that ion bombardment is dominant in the distribution of pressure and energy flux on the cathode surface while the electron emission current plays a most important role in the current density distribution. When increasing ion number density and electron temperature, the cathode temperature will increase significantly, and the cathode crater will be deeper and wider. But with the increase of the near-cathode voltage drop, the cathode temperature will be lower and the cathode crater will be shallower and narrower. Further analysis shows that the erosion depth is mainly closely related to the thermodynamic process while the droplet formation and sputtering are mainly caused by the interaction between surface tension and plasma pressure. At last, through the evaluation of the erosion rate, it can be seen that electrode erosion in high power gas switch is mainly caused by droplets. The numerical simulation results are in good agreement with the experiment.
Studies have confirmed the validity of malnutrition/inflammation-based indicators among cancer patients compared to chemotherapy patients. Moreover, it is necessary to identify which indicator is the ...best prognostic predictor for chemotherapy patients. This study attempted to determine the best nutrition/inflammation-based indicator of overall survival (OS) for chemotherapy patients.
In this prospective cohort study, we collected 16 nutrition/inflammation-based indicators among 3,833 chemotherapy patients. The maximally selected rank statistics were used to calculate the optimal values of cutoffs for continuous indicators. OS was evaluated using the Kaplan-Meier method. The associations of 16 indicators with survival were evaluated using Cox proportional hazard models. The predictive ability of 16 indicators was assessed
time-dependent receiver operating characteristic curves (time-ROC) and the C-index.
All indicators were significantly associated with worse OS of chemotherapy patients in the multivariate analyses (all P < 0.05). Time-AUC and C-index analyses indicated that the lymphocyte-to-CRP (LCR) ratio (C-index: 0.658) had the best predictive ability for OS in chemotherapy patients. The tumor stage significantly modified the association between inflammatory status and worse survival outcomes (P for interaction < 0.05). Compared to patients with high LCR and I/II tumor stages, patients with low LCR and III/IV tumor stages had a 6-fold higher risk of death.
The LCR has the best predictive value in chemotherapy patients compared with other nutrition/inflammation-based indicators.
http://www.chictr.org.cn, identifier ChiCTR1800020329.
Abstract
Background and aims
High-sensitivity C-reactive protein (hs-CRP) levels and metabolic syndrome (MetS) are known to be associated with an increased incidence of different cancers. We aimed to ...evaluate the effect of MetS combined with high hs-CRP levels on the risk of primary liver cancer (PLC).
Methods
Participants were recruited from the Kailuan cohort study and were classified into four groups according to the presence or absence of MetS and inflammation (hs-CRP ≥ 3 or < 3 mg/L). The associations of MetS and inflammation with the risk of PLC were assessed using Cox proportional hazards models.
Results
This study included 92,770 participants. The mean age was 51.4 years old. Over a median follow-up of 13.02 years, 395 participants were diagnosed as PLC. Compared to the control participants without inflammation (hs-CRP < 3 mg/L) and MetS (
n
= 69,413), participants with high hs-CRP levels combined with MetS (
n
= 2,269) had a higher risk of PLC hazard ratios (HR) 2.91; 95% confidence interval (CI), 1.77–4.81, and participants with high hs-CRP levels and without MetS (
n
= 14,576) had the same trend (HR, 1.36; 95%CI, 1.05–1.75). However, participants with low hs-CRP levels and MetS (
n
= 6,512) had no significant association with an elevated risk of PLC (HR, 1.18; 95%CI, 0.76–1.82). After excluding participants who had cancer during the first year of follow-up, sensitivity analysis showed the same trend. In addition, co-occurrence of MetS and high hs-CRP levels had significant interactive effects on the risk of PLC between the sexes (
P
< 0.001) and the patients with HBV infection (
P
= 0.012).
Conclusions
Participants with co-occurrence of MetS and high hs-CRP levels have an elevated risk of PLC.
Trial registration
Kailuan study, ChiCTR–TNRC–11001489. Registered 24 August, 2011-Retrospectively registered,
http://www.chictr.org.cn/showprojen.aspx?proj=8050
Previous studies have observed a close association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) as well as extrahepatic cancers. However, research concerning the ...effect of HBV infection on the risk of colorectal cancer (CRC) is rare and inconsistent. This study aims to determine the relationship between HBV infection and new-onset CRC.
We prospectively examined the relationship between HBV infection and new-onset CRC among 93,390 participants from Kailuan Cohort study. Cox proportional hazards regression models, subgroup analyses and competing risk analyses were used to evaluate the association between HBV infection and the risk of new-onset CRC.
During a median follow-up of 11.28 years, 448 incident CRC cases were identified. The adjusted HR (95%confidence interval (CI)) for the association of HBsAg Seropositive with CRC was 1.85(1.15 ~ 2.96) in the Cox regression. Subgroup analyses showed that the HBsAg seropositive group was associated with increased risk of new-onset CRC among male, middle-aged, normal weight, smokers and non-drinker participants, respectively. A positive association of HBV infection with the risk of CRC was observed in the adjusted sub-distribution proportional hazards (SD) models (HR
= 1.77, 95% CI:1.11-2.84) and cause-specific hazards (CS) models (HR
= 1.79, 95% CI: 1.13-2.91).
Our results have found a significant association between HBV infection and the risk of incident CRC among Chinese participants.
Kailuan study, ChiCTR-TNRC-11001489. Registered 24 August 2011 - Retrospectively registered, http:// http://www.chictr.org.cn/showprojen.aspx?proj=8050.
The antler is the unique mammalian organ found to be able to regenerate completely and periodically after loss, and the continuous proliferation and differentiation of mesenchymal cells and ...chondrocytes together complete the regeneration of the antler. Circular non-coding RNAs (circRNAs) are considered to be important non-coding RNAs that regulate body development and growth. However, there are no reports on circRNAs regulating the antler regeneration process. In this study, full-transcriptome high-throughput sequencing was performed on sika deer antler interstitial and cartilage tissues, and the sequencing results were verified and analyzed. The competing endogenous RNA (ceRNA) network related to antler growth and regeneration was further constructed, and the differentially expressed circRNA2829 was screened out from the network to study its effect on chondrocyte proliferation and differentiation. The results indicated that circRNA2829 promoted cell proliferation and increased the level of intracellular ALP. The analysis of RT-qPCR and Western blot demonstrated that the mRNA and protein expression levels of genes involved in differentiation rose. These data revealed that circRNAs play a crucial regulatory role in deer antler regeneration and development. CircRNA2829 might regulate the antler regeneration process through miR-4286-R+1/FOXO4.
This study examined the mediating role of guanxi harmony, a concept of interpersonal relationships specific to the Chinese context, between leaders’ emotion regulation strategies and employee ...motivation. Data were drawn from 489 on-the-job MBA students with enough management experience from thirteen different types of cities in China. The study tested the model using hierarchical regression. The results showed that the reappraisal strategy was positively related to employee motivation and the suppression strategy was negatively related to employee motivation in the Chinese context. Guanxi harmony played a partially mediating role between reappraisal and employee motivation, and played a fully mediating role between suppression and employee motivation. These findings suggest that in the Chinese context, guanxi harmony between leaders and employees has a positive effect on employee motivation, and when leaders apply appropriate emotion regulation strategies, they can achieve guanxi harmony and promote employee motivation.
PDF
