More than 75% of the Earth surface is covered by water in the form of oceans. The oceans are unexplored and very far-fetched to investigate due to distinct phenomenal activities in the underwater ...environment. Underwater wireless communication (UWC) plays a significant role in observation of marine life, water pollution, oil and gas rig exploration, surveillance of natural disasters, naval tactical operations for coastal securities and to observe the changes in the underwater environment. In this regard, the widespread adoption of UWC has become a vital field of study to envisage various military and commercial applications that have been growing interest to explore the underwater environment for numerous applications. Acoustic, Optical and RF wireless carriers have been chosen to be used for data transmission in an underwater environment. The internet of underwater things (IoUT) and next-generation (5G) networks have a great impact on UWC as they support the improvement of the data rate, connectivity, and energy efficiency. In addition to the potential emerging UWC techniques, assisted by 5G network and improve existing work is also focusing in this study. This survey presents a comprehensive overview of existing UWC techniques, with possible future directions and recommendations to enable the next generation wireless networking systems in the underwater environment. The current project schemes, applications and deployment of latest amended UWC techniques are also discussed. The main initiatives and contributions of current wireless communication schemes in underwater for improving quality of service and quality of energy of the system over long distances are also mentioned.
Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically validated by anticancer therapies that ...specifically inhibit oncoproteins such as BCR-ABL, c-Kit, HER2, PDGFR, and EGFR. Identifying additional genes that are required for tumor maintenance may lead to new targets for anticancer drugs. Although the role of aberrant Wnt pathway activation in the initiation of colorectal cancer has been clearly established, it remains unclear whether sustained Wnt pathway activation is required for colorectal tumor maintenance. To address this question, we used inducible β-catenin shRNAs to temporally control Wnt pathway activation in vivo. Here, we show that active Wnt/β-catenin signaling is required for maintenance of colorectal tumor xenografts harboring APC mutations. Reduced tumor growth upon β-catenin inhibition was due to cell cycle arrest and differentiation. Upon reactivation of the Wnt/β-catenin pathway colorectal cancer cells resumed proliferation and reacquired a crypt progenitor phenotype. In human colonic adenocarcinomas, high levels of nuclear β-catenin correlated with crypt progenitor but not differentiation markers, suggesting that the Wnt/β-catenin pathway may also control colorectal tumor cell fate during the maintenance phase of tumors in patients. These results support efforts to treat human colorectal cancer by pharmacological inhibition of the Wnt/β-catenin pathway.
This paper considers the problem of request distribution in a taxi company for workload optimization. A combined algorithm for request distribution using multi-objective optimization methods is ...offered.
Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically validated by anticancer therapies that ...specifically inhibit oncoproteins such as BCR-ABL, c-Kit, HER2, PDGFR, and EGFR. Identifying additional genes that are required for tumor maintenance may lead to new targets for anticancer drugs. Although the role of aberrant Wnt pathway activation in the initiation of colorectal cancer has been clearly established, it remains unclear whether sustained Wnt pathway activation is required for colorectal tumor maintenance. To address this question, we used inducible β-catenin shRNAs to temporally control Wnt pathway activation in vivo. Here, we show that active Wnt/β-catenin signaling is required for maintenance of colorectal tumor xenografts harboring APC mutations. Reduced tumor growth upon β-catenin inhibition was due to cell cycle arrest and differentiation. Upon reactivation of the Wnt/β-catenin pathway colorectal cancer cells resumed proliferation and reacquired a crypt progenitor phenotype. In human colonic adenocarcinomas, high levels of nuclear β-catenin correlated with crypt progenitor but not differentiation markers, suggesting that the Wnt/β-catenin pathway may also control colorectal tumor cell fate during the maintenance phase of tumors in patients. These results support efforts to treat human colorectal cancer by pharmacological inhibition of the Wnt/β-catenin pathway. PUBLICATION ABSTRACT
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