The present study reports on the encapsulation of
ethanolic extract by freeze-drying method using skim milk, sodium caseinate, gum Arabic, maltodextrin, beta-maltodextrin, and resistant-maltodextrin ...alone or in mixtures of two or four encapsulants. The encapsulation ability of the final mixtures was evaluated based on their microencapsulating efficiency (EE) of total phenolic compounds (TPC) and the physicochemical properties of freeze-dried powders. Results showed that the freeze-dried powders produced using two encapsulants have a lower moisture content, but higher solubility, Carr index, and Hausner ratio than freeze-dried powders produced using only one encapsulant in the formulation. The microencapsulating efficiency of TPC also varied depending on encapsulants used. The lowest EE% of TPC was determined with maltodextrin (21.17%), and the highest with sodium caseinate (83.02%). Scanning electron microscopy revealed that freeze-drying resulted in the formation of different size, irregular shape glassy particles. This study demonstrated good mucoadhesive properties of freeze-dried powders, which could be incorporated in buccal or oral delivery dosage forms. In conclusion, the microencapsulation of
ethanolic extract by freeze-drying is an effective method to produce new value-added pharmaceutical or food formulations with polyphenols.
Unlike Western European countries, in Poland, there are two groups of native Muslim citizens: the Tatars and converts to Islam. They differ from mainstream society by their religion - Islam, and the ...Tatars, additionally, by their ethnicity. However, one of these groups - Islam converts - is racialised by the other. We argue that the Polish Tatars can use the repertoire of both sides - non-Muslim mainstream society and born Muslims - in order to otherise and racialise Polish converts to Islam. As autochthonous Poles, whose membership in mainstream society has never been questioned, they can employ strategies used by non-Muslims. As born Muslims they can build on the wide range of strategies against Islam newcomers. Moreover, the racialisation of Polish converts seems to be a strategy that aims to maintain the boundaries between these two groups and the positive self-assessment of the Tatars. This article contributes to the scholarship on racialisation of white converts to Islam by bringing out the local context with unique dynamics and power relations between different groups of Muslims.
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Cynaroside (CYN) is the predominant derivative of luteolin in aerial parts of Bidens tripartita which has been used in folk medicine as a diaphoretic, diuretic, antiseptic and ...anti-inflammatory agent. In our study, alginate (ALG), which is an anionic polymer with bioadhesive properties, was used as a CYN carrier, and multiple hydrogel formulations were created. Additionally, the present study evaluated the in vivo anti-inflammatory and anti-allergic activities of all preparations.
Novel gel formulations as topical carriers for CYN obtained from B. tripartita were developed and characterized. The bioadhesive properties of the designed preparations were also evaluated in an ex vivo model using the skin of hairless mice. In vitro CYN release from all formulations was examined and analysed by HPLC. Histopathological evaluation of mouse skin sections stained with H&E after carrageenan and oxazolone administration was also carried out. In addition, the influence of CYN on cell proliferation was examined by the PCNA staining method.
The results showed that 10 % CYN inhibited the release of anti-inflammatory mediators, and both tested concentrations, which included 5 % and 10 % (2 mg and 20 mg CYN per site, respectively), reduced oxazolone-induced ear swelling. Histopathological examination of the samples revealed a marked reduction in paw skin and ear tissue inflammation and in inflammatory infiltrates. The influence of CYN on cell proliferation was examined by the PCNA staining method, and the staining and distribution of PCNA-immunoreactive (PCNA-IR) cells were observed. After the application of the 5 % and 10 % hydrogels, the investigated samples showed decreased nuclear immunoreactivity to PCNA, which was similar to that of the control. Moreover, after application of the placebo formulation, fewer PCNA-IR cells were also observed.
The obtained data suggest that the topical application of CYN significantly reduces the number of T cells, mast cells and histiocytes in mouse skin with inflammation or atopic dermatitis.
Purpose
The aim of the paper is to theoretically and empirically explore the issue of well-being (WB) of female administrative employees who work on managerial positions at higher education ...institutions (HEIs).
Design/methodology/approach
This study is based on both literature studies and explorative empirical research conducted in Poland with the use of snowball sampling. It adopted a questionnaire authored by Parker and Hyett and covered 121 respondents.
Findings
Literature studies show that invisibility of work, low level of empowerment, increased stress, workload and expectations, reduced resources, high level of anxiety, fatigue and low level of vitality negatively impact the WB of HEIs’ administrative staff. The presented research provides insight into the internal structure of the administrative staff’s WB. Both the main construct (i.e. employees’ WB) and its subconstructs are on moderate level. Respondents’ age and tasks performed are correlated only with the subconstruct of WB in the form of intrusion of work into private life.
Research limitations/implications
Although the research is not based on large sample, it provides both practical and theoretical implications.
Originality/value
Most of studies discuss the issue of WB of scholars. The paper fills the research gap in terms of examining female administrative employees who work on managerial positions at HEIs.
Hydrogels are semi-solid systems with high flexibility, which, due to holding large amounts of water, are similar to natural tissues and are very useful in the field of biomedical applications. ...Despite the wide range of polymers available to form hydrogels, novel techniques utilized to obtain hydrogels with adequate properties are still being developed. The aim of this study was to evaluate the impact of the freeze–thaw technique on the properties of cryogels based on sodium alginate and chitosan glutamate with posaconazole as a model antifungal substance. The effect of the freezing and thawing process on the physicochemical, rheological, textural and bioadhesive properties of prepared cryogels was examined. Additionally, the antifungal activity against Candida albicans, Candida parapsilosis and Candida krusei of designed formulations was examined. It was shown that the freeze–thaw technique significantly improved viscosity, bioadhesiveness, textural properties and prolonged the in vitro posaconazole release. Moreover, alginate/chitosan glutamate cryogels exhibited higher values of inhibition zone in C. parapsilosis culture than traditional hydrogel formulations.
Alginate (ALG) cross-linking by CaCl₂ is a promising strategy to obtain modified-release drug delivery systems with mucoadhesive properties. However, current technologies to produce CaCl₂ ...cross-linked alginate microparticles possess major disadvantages, such as a poor encapsulation efficiency of water-soluble drugs and a difficulty in controlling the process. Hence, this study presents a novel method that streamlines microparticle production by spray drying; a rapid, continuous, reproducible, and scalable technique enabling obtainment of a product with low moisture content, high drug loading, and a high production yield. To model a freely water-soluble drug, metformin hydrochloride (MF) was selected. It was observed that MF was successfully encapsulated in alginate microparticles cross-linked by CaCl₂ using a one-step drying process. Modification of ALG provided drug release prolongation-particles obtained from 2% ALG cross-linked by 0.1% CaCl₂ with a prolonged MF rate of dissolution of up to 12 h. Cross-linking of the ALG microparticles structure by CaCl₂ decreased the swelling ratio and improved the mucoadhesive properties which were evaluated using porcine stomach mucosa.
The first systematic study of conversion to Islam among Polish women in English, this book offers insights about lived realities of female Polish converts who create dynamic strategies of managing ...their spoiled identities in a variety of contexts including Poland and the UK.
species are opportunistic fungi, which are primary causative agents of vulvovaginal candidiasis. The cure of candidiasis is difficult, lengthy, and associated with the fungi resistivity. Therefore, ...the research for novel active substances and unconventional drug delivery systems providing effective and safe treatment is still an active subject. Microparticles, as multicompartment dosage forms due to larger areas, provide short passage of drug diffusion, which might improve drug therapeutic efficiency. Sodium alginate is a natural polymer from a polysaccharide group, possessing swelling, mucoadhesive, and gelling properties. Gelatin A is a natural high-molecular-weight polypeptide obtained from porcine collagen. The purpose of this study was to prepare microparticles by the spray-drying of alginate/gelatin polyelectrolyte complex mixture, with a novel antifungal drug-luliconazole. In the next stage of research, the effect of gelatin presence on pharmaceutical properties of designed formulations was assessed. Interrelations among polymers were evaluated with thermal analysis and Fourier transform infrared spectroscopy. A valid aspect of this research was the in vitro antifungal activity estimation of designed microparticles using
species:
,
, and
. It was shown that the gelatin addition affected the particles size, improved encapsulation efficiency and mucoadhesiveness, and prolonged the drug release. Moreover, gelatin addition to the formulations improved the antifungal effect against
species.
Abstract
This article explores the conversion processes of Polish women of Catholic background to Islam. Data from participant observation of mosque-based, women-only weekend gatherings for converts ...and in-depth interviews with 29 Polish female converts to Islam are presented to illustrate the dialectic between the persistence and transformation of religious habitus. Our analysis demonstrates that in the conversion process, Catholic habitus remains pervasive, and shapes converts’ engagement with the new religion; however, some elements of it become reflexive and change. We make a case for extending the discussion on habitus transformation by drawing attention to what we term a “translation” of religious beliefs and practices. Women in our study translate the system of Islamic practices and beliefs into a specific Catholic logic that is more intelligible to them and, in the process, recognize some of the power dynamics inherent in the religious field.
This article focuses on converts to Islam in Poland, taking into account the specific socio-cultural, political, and historical contexts and new trends that have emerged with the gradual growth of ...the Muslim population. We draw attention to the unique patterns of practices related to Islam and patterns of belonging. Eastern European Islam remains relatively under-researched and, as a consequence, there is little clarity whether processes identified in relation to Western European Islam are mirrored in Eastern Europe. In line with the current literature, we propose the concept of 'Polish Islam' as an analytical tool. Based on 16 interviews with Polish female converts, this article traces the way meanings of religious teachings and practices are negotiated and integrated into daily social interactions. We analyse participants' views regarding the fit between Islam and the national culture. Expanding on the finding that Polish converts to Islam in our sample do not consider themselves to be outsiders, we explore the implications of this pragmatic stance and discuss that the majority of our respondents choose to amalgamate Polish cultural practices with their new religion and renegotiate the meanings of these practices.
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