We present the Super Eight galaxies-a set of very luminous, high-redshift (7.1 < z < 8.0) galaxy candidates found in the Brightest of Reionizing Galaxies (BoRG) Survey fields. The original sample ...includes eight galaxies that are Y-band dropout objects with H-band magnitudes of mH < 25.5. Four of these objects were originally reported in Calvi et al. Combining new Hubble Space Telescope (HST) WFC3/F814W imaging and Spitzer IRAC data with archival imaging from BoRG and other surveys, we explore the properties of these galaxies. Photometric redshift fitting places six of these galaxies in the redshift range of 7.1 < z < 8.0, resulting in three new high-redshift galaxies and confirming three of the four high-redshift galaxy candidates from Calvi et al. We calculate the half-light radii of the Super Eight galaxies using the HST F160W filter and find that the Super Eight sizes are in line with the typical evolution of size with redshift. The Super Eights have a mean mass of log (M*/M ) ∼10, which is typical for sources in this luminosity range. Finally, we place our sample on the UV z ∼ 8 luminosity function and find that the Super Eight number density is consistent with other surveys in this magnitude and redshift range.
Redshift z = 9-10 object selection is the effective limit of Hubble Space Telescope (HST) imaging capability, even when confirmed with Spitzer. If only a few photometry data points are available, it ...becomes attractive to add criteria based on their morphology in these J- and H-band images. One could do so through visual inspection, a size criterion, or alternate morphometrics. We explore a vetted sample of Brightest of Reionizing Galaxies (BoRG) z ∼ 9 and z ∼ 10 candidate galaxies and the object rejected by Morishita+ to explore the utility of a size criterion in z = 9-10 candidate selection. A stringent, point-spread function (PSF)-corrected effective radius criterion ( ) would result in the rejection of 65%-70% of the interlopers visually rejected by Morishita et al. It may also remove up to ∼20% of bona fide brightest ( ) z = 9 or 10 candidates from a BoRG selected sample based on the Mason et al. luminosity functions, assuming the Holwerda et al. size-luminosity relation. We argue that including a size constraint in lieu of a visual inspection may serve in wide-field searches for these objects in, e.g., Euclid or HST archival imaging with the understanding that some brightest ( ) candidates may be missed. The sizes of the candidates found by Morishita et al. follow the expected size distribution of z ∼ 9 for bright galaxies, consistent with the log normal in Shibuya et al. and single objects. Two candidates show high star formation surface density ( ) and all merit further investigation and follow-up observations.
Ileocolic resection for Crohn's disease traditionally does not include a high ligation of the ileocolic pedicle, and most commonly is performed with a stapled side-to-side ileocolic anastomosis. The ...mesentery has recently been implicated in the pathophysiology of Crohn's disease. Two techniques have been developed and are associated with reduced postoperative recurrence: the Kono-S anastomosis that excludes diseased mesentery and extended mesenteric excision that resects diseased mesentery. We aimed to assess the technical feasibility and safety of a novel combination of techniques: mesenteric excision and exclusion.
This initial report is a single-center descriptive study of consecutive adults who underwent mesenteric excision and exclusion for primary or recurrent ileocolic Crohn's disease from September 2020 to June 2021. Medication exposure and endoscopic balloon dilation before surgery were recorded. Phenotype was classified using the Montreal Classification. Thirty-day outcomes were reported. A video of the mesenteric excision and exclusion including the Kono-S anastomosis is presented.
Twenty-two patients with ileocolic Crohn's disease underwent mesenteric excision and exclusion: 100% had strictures, 59% had fistulas, 81% were on biologics, and 27% had previous ileocolic resection(s). Seventy-two percent underwent laparoscopic procedures, a mesenteric defect was closed in 86%, omental flaps were fashioned in 77%, and 3 patients were diverted. Median operative time was 175 minutes. Median postoperative stay was 4 days. At 30 days, there were 2 readmissions for reintervention: 1 seton placement and 1 percutaneous drainage of a sterile collection. There were no cases of intra-abdominal sepsis or anastomotic leak.
Mesenteric excision and exclusion represents an innovative, progressive, and promising approach that appears to be highly feasible and safe. Further study is warranted to determine if mesenteric excision and exclusion is associated with reduced postoperative recurrence of ileocolic Crohn's disease.
The COVID-19 pandemic is devastating post-acute and long-term care (PA/LTC). As geriatricians practicing in PA/LTC and a regional academic medical center, we created this program for collaboration ...between academic medical centers and regional PA/LTC facilities. The mission of the Geriatric Engagement and Resource Integration in Post-Acute and Long-Term Care Facilities (GERI-PaL) program is to support optimal care of residents in PA/LTC facilities during the COVID-19 pandemic. There are 5 main components of our program: (1) Project ECHO; (2) nursing liaisons; (3) infection advisory consultation; (4) telemedicine consultation; and (5) resident social contact remote connections. Implementation of this program has had positive response from our local PA/LTC facilities. A key component of our program is our interprofessional team, which includes physicians and nursing, emergency response, and public health experts. With diverse professional backgrounds, our team members have created a new model for academic medical centers to collaborate with local PA/LTC facilities.
Abstract
Strong gravitational lenses are a rare and instructive type of astronomical object. Identification has long relied on serendipity, but different strategies—such as mixed spectroscopy of ...multiple galaxies along the line of sight, machine-learning algorithms, and citizen science—have been employed to identify these objects as new imaging surveys become available. We report on the comparison between spectroscopic, machine-learning, and citizen-science identification of galaxy–galaxy lens candidates from independently constructed lens catalogs in the common survey area of the equatorial fields of the Galaxy and Mass Assembly survey. In these, we have the opportunity to compare high completeness spectroscopic identifications against high-fidelity imaging from the Kilo Degree Survey used for both machine-learning and citizen-science lens searches. We find that the three methods—spectroscopy, machine learning, and citizen science—identify 47, 47, and 13 candidates, respectively, in the 180 square degrees surveyed. These identifications barely overlap, with only two identified by both citizen science and machine learning. We have traced this discrepancy to inherent differences in the selection functions of each of the three methods, either within their parent samples (i.e., citizen science focuses on low redshift) or inherent to the method (i.e., machine learning is limited by its training sample and prefers well-separated features, while spectroscopy requires sufficient flux from lensed features to lie within the fiber). These differences manifest as separate samples in estimated Einstein radius, lens stellar mass, and lens redshift. The combined sample implies a lens candidate sky density of ∼0.59 deg
−2
and can inform the construction of a training set spanning a wider mass–redshift space. A combined approach and refinement of automated searches would result in a more complete sample of galaxy–galaxy lens candidates for future surveys.
In the face of changing environmental conditions, the mechanisms underlying stress responses in diverse organisms are of increasing interest. In vertebrates, Drosophila, and Caenorhabditis elegans, ...FoxO transcription factors mediate cellular responses to stress, including oxidative stress and dietary restriction. Although FoxO genes have been identified in early-arising animal lineages including sponges and cnidarians, little is known about their roles in these organisms.
We have examined the regulation of FoxO activity in members of the well-studied cnidarian genus Hydra. We find that Hydra FoxO is expressed at high levels in cells of the interstitial lineage, a cell lineage that includes multipotent stem cells that give rise to neurons, stinging cells, secretory cells and gametes. Using transgenic Hydra that express a FoxO-GFP fusion protein in cells of the interstitial lineage, we have determined that heat shock causes localization of the fusion protein to the nucleus. Our results also provide evidence that, as in bilaterian animals, Hydra FoxO activity is regulated by both Akt and JNK kinases.
These findings imply that basic mechanisms of FoxO regulation arose before the evolution of bilaterians and raise the possibility that FoxO is involved in stress responses of other cnidarian species, including corals.
Populations of marsh-breeding birds have declined throughout the southern Laurentian Great Lakes basin. To advance conservation of these species, we used occupancy modeling, a regional prioritization ...scheme, and data from Birds Canada’s Great Lakes Marsh Monitoring Program (2016–2018) to describe species-habitat relationships and identify priority habitat areas for 7 obligate marsh-breeding bird species in southern Ontario, Canada: American bittern (Botaurus lentiginosus), common gallinule (Gallinula galeata), least bittern (Ixobrychus exilis), marsh wren (Cistothorus palustris), pied-billed grebe (Podilymbus podiceps), sora (Porzana carolina), and Virginia rail (Rallus limicola). Given these species respond to land cover at widely varying spatial scales, we initially identified the most informative scale (buffer = 100 m, 200 m, 400 m, 800 m, 1,600 m, 3,200 m, or 6,400 m) for marsh, urban, agricultural, and forest cover to increase model performance. We also considered climate variables, whether sample sites were along a Great Lakes coastline or inland, and covariates influencing detection. Occupancy was best explained by land cover at a wide range of spatial scales depending on the species. All species except Virginia rail responded positively to marsh cover; American bittern and Virginia rail responded negatively to urban cover; least bittern, pied-billed grebe, and Virginia rail responded negatively and sora responded positively to agricultural cover; and American bittern, common gallinule, marsh wren, and pied-billed grebe responded negatively and Virginia rail responded positively to forest cover. Only American bittern responded negatively to mean May–June temperature; only pied-billed grebe responded positively to start of growing season; and only Virginia rail had higher occupancy at inland marshes compared to coastal. We combined predictions from the best model for each of 5 species with reasonably good model fit (we excluded sora and Virginia rail) to identify priority habitat areas for marsh-breeding birds. Expansion of wetland conservation work from existing priority areas based on waterfowl to also include these new additional priority areas based on marsh-breeding birds will be an important step towards conservation of all birds, and will help slow or maybe even reverse declining population trends. Some restoration activities outside but adjacent to priority areas will also be important for rebuilding marshes for these species across this intensively farmed and developed region.
Aim
The management of anastomotic leak after sigmoid colectomy for diverticular disease has not been well defined. Specifically, there is a lack of literature on optimal types of reoperations for ...leaks. The aim of this study was to describe and compare reoperative approaches and their postoperative outcomes.
Methods
We performed a retrospective cohort study using the NSQIP Colectomy Module (2012–2019) and single‐institution chart review. Patients with diverticular disease who underwent elective sigmoid colectomy were included. Primary outcomes were anastomotic leak requiring reoperation and management of anastomotic leak.
Results
Of 37,471 patients who underwent sigmoid colectomy for diverticular disease, 1003 (2.7%) suffered an anastomotic leak, of whom 583 underwent reoperation. Of the 572 patients who were not initially diverted and underwent reoperation for leak, 302 (52.8%) were managed with stoma creation – 200 (35.0%) with colostomy and 102 (17.8%) with ileostomy. The remaining 47.2% underwent colectomy with reanastomosis, suturing of large bowel, and drainage. There were no differences in length of stay, readmission, or mortality between patients who underwent ileostomy or colostomy at reoperation (p > 0.05). Single‐institution analysis demonstrated that 100% of patients with ileostomies underwent subsequent ileostomy closure, compared to 60% of patients with colostomies.
Conclusions
In patients who suffer anastomotic leaks after sigmoid colectomy for diverticular disease and undergo reoperations, ileostomy at the time of reoperation appears to be safe, with comparable results to colostomy. Ileostomies were more frequently closed than colostomies. When faced with a colorectal anastomotic leak, ileostomy creation may be considered.
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