Prunus spinosa L. (blackthorn) flower was most recently pointed out as a valuable source of bioactive compounds that have potent anticancer properties. To test for antineoplastic activity, ...hepatocarcinoma cells (Hepa 1–6) and corresponding non-neoplastic hepatocytes (AML 12) were subjected to Prunus spinosa L. blossom ethanolic extract (5–200 μg mL−1). Antiproliferative activity was determined by Trypan Blue (TB) and Kenacid Blue (KB) methods after 24 and 72 h. Inhibitory effects on Hepa 1–6 proliferation were observed at all concentrations with significant inhibition at ≥100 μg mL−1 (p < .025–p < .001) determined with both methods. Cytotoxicity was also detected in non-neoplastic hepatocytes with significant doses above 10 μg mL−1 (p < .05–p < .001) after 72 h. Cellular viability loss after 24 h was more pronounced in non-neoplastic vs. hepatocarcinoma cells as confirmed with IC50TB values (half maximal inhibitory concentration): 59.05 μg mL−1 in AML 12 vs. 166.87 μg mL−1 in Hepa 1–6 cells and IC50KB: 72.69 vs. 172.93 μg mL−1, respectively. Prolonged incubation (72 h) resulted in almost equal toxicity in both cell lines. Prooxidative activity of blackthorn flower extract was observed in both cell lines with higher ROS formation in neoplastic cells. Cell death was primarily through necrosis. The proportion of apoptotic cells in both cultures was low: fraction of early apoptosis – 0.04–1.65% of the total cell population and fraction of late apoptosis: only 0.05–3.25%.
•Prunus spinosa flower extract showed cytotoxicity in non-neoplastic hepatocytes and hepatocarcinoma cells.•Prooxidative activity of extract was expressed in both cell lines with higher ROS formation in neoplastic cells.•Cell death was primarily through necrosis – significant in both cell lines.•A precaution in ethno-pharmaceutical usage and human nutrition is advised.
We report measurements of the exclusive neutral pion electroproduction cross section off protons at large values of xB (0.36, 0.48, and 0.60) and Q2 (3.1 to 8.4 GeV2) obtained from Jefferson Lab ...Hall A experiment E12-06-014. The corresponding structure functions dσT/ d t + ε dσL/ d t , dσTT / d t , d σ L T / d t , and d σ L T ′ / d t are extracted as a function of the proton momentum transfer t−tmin. The results suggest the amplitude for transversely polarized virtual photons continues to dominate the cross section throughout this kinematic range. The data are well described by calculations based on transversity generalized parton distributions coupled to a helicity flip distribution amplitude of the pion, thus providing a unique way to probe the structure of the nucleon.
We report measurements of the exclusive neutral pion electroproduction cross section off protons at large values of $x_B$ (0.36, 0.48 and 0.60) and $Q^2$ (3.1 to 8.4 GeV$^2$) obtained from Jefferson ...Lab Hall A experiment E12-06-014. The corresponding structure functions $d\sigma_L/dt+\epsilon d\sigma_T/dt$, $d\sigma_{TT}/dt$, $d\sigma_{LT}/dt$ and $d\sigma_{LT'}/dt$ are extracted as a function of the proton momentum transfer $t-t_{min}$. The results suggest the amplitude for transversely polarized virtual photons continues to dominate the cross-section throughout this kinematic range. The data are well described by calculations based on transversity Generalized Parton Distributions coupled to a helicity flip Distribution Amplitude of the pion, thus providing a unique way to probe the structure of the nucleon.
We report high-precision measurements of the Deeply Virtual Compton
Scattering (DVCS) cross section at high values of the Bjorken variable $x_B$.
DVCS is sensitive to the Generalized Parton ...Distributions of the nucleon, which
provide a three-dimensional description of its internal constituents. Using the
exact analytic expression of the DVCS cross section for all possible
polarization states of the initial and final electron and nucleon, and final
state photon, we present the first experimental extraction of all four
helicity-conserving Compton Form Factors (CFFs) of the nucleon as a function of
$x_B$, while systematically including helicity flip amplitudes. In particular,
the high accuracy of the present data demonstrates sensitivity to some very
poorly known CFFs.
Phys. Rev. Lett. 127, 152301 (2021) We report measurements of the exclusive neutral pion electroproduction cross
section off protons at large values of $x_B$ (0.36, 0.48 and 0.60) and $Q^2$
(3.1 to ...8.4 GeV$^2$) obtained from Jefferson Lab Hall A experiment E12-06-014.
The corresponding structure functions $d\sigma_L/dt+\epsilon d\sigma_T/dt$,
$d\sigma_{TT}/dt$, $d\sigma_{LT}/dt$ and $d\sigma_{LT'}/dt$ are extracted as a
function of the proton momentum transfer $t-t_{min}$. The results suggest the
amplitude for transversely polarized virtual photons continues to dominate the
cross-section throughout this kinematic range. The data are well described by
calculations based on transversity Generalized Parton Distributions coupled to
a helicity flip Distribution Amplitude of the pion, thus providing a unique way
to probe the structure of the nucleon.
We report high-precision measurements of the Deeply Virtual Compton Scattering (DVCS) cross section at high values of the Bjorken variable \(x_B\). DVCS is sensitive to the Generalized Parton ...Distributions of the nucleon, which provide a three-dimensional description of its internal constituents. Using the exact analytic expression of the DVCS cross section for all possible polarization states of the initial and final electron and nucleon, and final state photon, we present the first experimental extraction of all four helicity-conserving Compton Form Factors (CFFs) of the nucleon as a function of \(x_B\), while systematically including helicity flip amplitudes. In particular, the high accuracy of the present data demonstrates sensitivity to some very poorly known CFFs.
We report measurements of the exclusive neutral pion electroproduction cross section off protons at large values of \(x_B\) (0.36, 0.48 and 0.60) and \(Q^2\) (3.1 to 8.4 GeV\(^2\)) obtained from ...Jefferson Lab Hall A experiment E12-06-014. The corresponding structure functions \(d\sigma_L/dt+\epsilon d\sigma_T/dt\), \(d\sigma_{TT}/dt\), \(d\sigma_{LT}/dt\) and \(d\sigma_{LT'}/dt\) are extracted as a function of the proton momentum transfer \(t-t_{min}\). The results suggest the amplitude for transversely polarized virtual photons continues to dominate the cross-section throughout this kinematic range. The data are well described by calculations based on transversity Generalized Parton Distributions coupled to a helicity flip Distribution Amplitude of the pion, thus providing a unique way to probe the structure of the nucleon.
March 1, 1995--A. Schulman Inc. announced that it has completed the acquisition of the business and assets of the Polymer Services Division of the J. M. Huber Corporation. No financial details of the ...transaction were disclosed. Polymer Services, located in Orange, Texas, is a supplier of engineered plastic compounds, custom compounding and tolling services. It will add 10 manufacturing lines and a 143,000 square foot plant to A. Schulman's current production facilities. Terry L. Haines, president and CEO of A. Schulman, said, "This acquisition provides needed additional manufacturing capacity for our current and future growth. It also enables us to be a more full service supplier to the plastics industry and enhances our strategic relationships with key polymer suppliers." (excerpt)
October 21, 1994--A. Schulman Inc. said that its revenues and net income set records for both the fourth quarter and fiscal year ended August 31, 1994. Net income for the fourth quarter was ...$13,761,000 or $.37 per common share, an increase of 14% over earnings of $12,024,000 or $.32 per share for the same period last year. Revenues were $210.7 million compared with $160.4 million in last year's fourth quarter. For the fiscal year ended August 31, 1994, revenues and net income were the highest in the history of A. Schulman. The Company's net income has established new records in eleven of the last twelve fiscal years. Net income for fiscal 1994 was $44,571,000 or $1.19 per common share, up 15% from 1993 earnings of $38,907,000 or $1.04 per share before accounting changes. Revenues were $756.2 million, 9% higher than last year's revenues of $693.2 million. (excerpt)
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