A novel human gene RED, and the murine homologue, MuRED, were cloned. These genes were named after the extensive stretch of alternating arginine (R) and glutamic acid (E) or aspartic acid (D) ...residues that they contain. We term this the ‘RED’ repeat. The genes of both species were expressed in a wide range of tissues and we have mapped the human gene to chromosome 5q22–24. MuRED and RED shared 98% sequence identity at the amino acid level. The open reading frame of both genes encodes a 557 amino acid protein. RED fused to a fluorescent tag was expressed in nuclei of transfected cells and localised to nuclear dots. Co-localisation studies showed that these nuclear dots did not contain either PML or Coilin, which are commonly found in the POD or coiled body nuclear compartments. Deletion of the amino terminal 265 amino acids resulted in a failure to sort efficiently to the nucleus, though nuclear dots were formed. Deletion of a further 50 amino acids from the amino terminus generates a protein that can sort to the nucleus but is unable to generate nuclear dots. Neither construct localised to the nucleolus. The characteristics of RED and its nuclear localisation implicate it as a regulatory protein, possibly involved in transcription.
We present 0.25 arcsec resolution (35 au) ALMA 1.3 mm dust polarization observations for 37 young stellar objects (YSOs) in the Ophiuchus cloud. These data encompass all the embedded protostars in ...the cloud and several Flat and Class II objects to produce the largest, homogeneous study of dust polarization on disk scales to date. The goal of this study is to study dust polarization down to disk scales. We find that 14/37 (38%) of the YSOs are detected in polarization. Nine of these sources have uniform polarization angles and four sources have azimuthal polarization. The sources with uniform polarization tend to have steeper inclinations (> 60 degree) than those with azimuthal polarization (< 60 degree). The majority (9/14) of the detected sources have polarization morphologies and disk properties consistent with dust self-scattering in optically thick disks. The remaining sources may be instead tracing magnetic fields. Their inferred field directions from rotating the polarization vectors by 90 degree are mainly poloidal or hourglass shaped. We find no evidence of a strong toroidal field component toward any of our disks. For the 23 YSOs that are undetected in polarization, roughly half of them have 3-sigma upper limits of < 2%. These sources also tend to have inclinations < 60 degree and they are generally compact. Since lower inclination sources tend to have azimuthal polarization, these YSOs may be undetected in polarization due to unresolved polarization structure within our beam. We propose that disks with inclinations > 60 degree are the best candidates for future polarization studies of dust self-scattering as these systems will generally show uniform polarization vectors that do not require very high resolution to resolve. We release the continuum and polarization images for all the sources with this publication. Data from the entire survey can be obtained from Dataverse.
We present high-resolution (~ 35 au) ALMA Band 6 1.3 mm dust polarization observations of IRAS 16293. These observations spatially resolve the dust polarization across the two protostellar sources ...and toward the filamentary structures between them. The dust polarization and inferred magnetic field have complicated structures throughout the region. In particular, we find that the magnetic field is aligned parallel to three filamentary structures. We characterize the physical properties of the filamentary structure that bridges IRAS 16293A and IRAS 16293B and estimate a magnetic field strength of 23-78 mG using the Davis-Chandrasekhar-Fermi method. We construct a toy model for the bridge material assuming that the young stars dominate the mass and gravitational potential of the system. We find that the expected gas flow to each star is of comparable order to the Alfven speed, which suggests that the field may be regulating the gas flow. We also find that the bridging material should be depleted in ~ 1000 yr. If the bridge is part of the natal filament that formed the stars, then it must have accreted new material. Alternatively, the bridge could be a transient structure. Finally, we show that the 1.3 mm polarization morphology of the optically thick IRAS 16293B system is qualitatively similar to dust self-scattering. Based on similar polarization measurements at 6.9 mm, we propose that IRAS 16293B has produced a substantial population of large dust grains with sizes between 200 and 2000 um.
In the standard picture for low-mass star formation, a dense molecular cloud undergoes gravitational collapse to form a protostellar system consisting of a new central star, a circumstellar disk, and ...a surrounding envelope of remaining material. The mass distribution of the system evolves as matter accretes from the large-scale envelope through the disk and onto the protostar. While this general picture is supported by simulations and indirect observational measurements, the specific timescales related to disk growth and envelope dissipation remain poorly constrained. In this paper we conduct a rigorous test of a method introduced by Jørgensen et al. (2009) to obtain mass measurements of disks and envelopes around embedded protostars with observations that do not resolve the disk (resolution of \(\sim\)1000\,AU). Using unresolved data from the recent Mass Assembly of Stellar Systems and their Evolution with the SMA (MASSES) survey, we derive disk and envelope mass estimates for \(59\) protostellar systems in the Perseus molecular cloud. We compare our results to independent disk mass measurements from the VLA Nascent Disk and Multiplicity (VANDAM) survey and find a strong linear correlation, suggesting that accurate disk masses can be measured from unresolved observations. Then, leveraging the size of the MASSES sample, we find no significant trend in protostellar mass distribution as a function of age, as approximated from bolometric temperatures. These results may indicate that the disk mass of a protostar is set near the onset of the Class 0 protostellar stage and remains roughly constant throughout the Class I protostellar stage.
We present high resolution (~ 30 au) ALMA Band 6 dust polarization observations of VLA 1623. The VLA 1623 data resolve compact ~ 40 au inner disks around the two protobinary sources, VLA 1623-A and ...VLA 1623-B, and also an extended ~ 180 au ring of dust around VLA 1623-A. This dust ring was previously identified as a large disk in lower-resolution observations. We detect highly structured dust polarization toward the inner disks and the extended ring with typical polarization fractions ~ 1.7% and ~ 2.4%, respectively. The two components also show distinct polarization morphologies. The inner disks have uniform polarization angles aligned with their minor axes. This morphology is consistent with expectations from dust scattering. By contrast, the extended dust ring has an azimuthal polarization morphology not previously seen in lower-resolution observations. We find that our observations are well fit by a static, oblate spheroid model with a flux-frozen, poloidal magnetic field. We propose that the polarization traces magnetic grain alignment likely from flux freezing on large scales and magnetic diffusion on small scales. Alternatively, the azimuthal polarization may be attributed to grain alignment by the anisotropic radiation field. If the grains are radiatively aligned, then our observations indicate that large (~ 100 um) dust grains grow quickly at large angular extents. Finally, we identify significant proper motion of VLA 1623 using our observations and those in the literature. This result indicates that the proper motion of nearby systems must be corrected for when combining ALMA data from different epochs.
