Recent advances in nonlinear optics have revolutionized integrated photonics, providing on-chip solutions to a wide range of new applications. Currently, state of the art integrated nonlinear ...photonic devices are mainly based on dielectric material platforms, such as Si
N
and SiO
. While semiconductor materials feature much higher nonlinear coefficients and convenience in active integration, they have suffered from high waveguide losses that prevent the realization of efficient nonlinear processes on-chip. Here, we challenge this status quo and demonstrate a low loss AlGaAs-on-insulator platform with anomalous dispersion and quality (Q) factors beyond 1.5 × 10
. Such a high quality factor, combined with high nonlinear coefficient and small mode volume, enabled us to demonstrate a Kerr frequency comb threshold of only ∼36 µW in a resonator with a 1 THz free spectral range, ∼100 times lower compared to that in previous semiconductor platforms. Moreover, combs with broad spans (>250 nm) have been generated with a pump power of ∼300 µW, which is lower than the threshold power of state-of the-art dielectric micro combs. A soliton-step transition has also been observed for the first time in an AlGaAs resonator.
The ability to spectrally translate lightwave signals in a compact, low-power platform is at the heart of the promise of nonlinear nanophotonic technologies. For example, a device to connect the ...telecommunications band with visible and short near-infrared wavelengths can enable a connection between high-performance chip-integrated lasers based on scalable nanofabrication technology with atomic systems used for time and frequency metrology. Although second-order nonlinear (χ(2)) systems are the natural approach for bridging such large spectral gaps, here we show that third-order nonlinear (χ(3)) systems, despite their typically much weaker nonlinear response, can realize spectral translation with unprecedented performance. By combining resonant enhancement with nanophotonic mode engineering in a silicon nitride microring resonator, we demonstrate efficient spectral translation of a continuous-wave signal from the telecom band (~1,550 nm) to the visible band (~650 nm) through cavity-enhanced four-wave mixing. We achieve such translation over a wide spectral range >250 THz with a translation efficiency of (30.1 ± 2.8)% and using an ultralow pump power of (329 ± 13) μW. The translation efficiency projects to (274 ± 28)% at 1 mW and is more than an order of magnitude larger than what has been achieved in current nanophotonic devices.
The combination of ivosidenib - an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) - and azacitidine showed encouraging clinical activity in a phase 1b trial involving patients with newly ...diagnosed
-mutated acute myeloid leukemia.
In this phase 3 trial, we randomly assigned patients with newly diagnosed
-mutated acute myeloid leukemia who were ineligible for intensive induction chemotherapy to receive oral ivosidenib (500 mg once daily) and subcutaneous or intravenous azacitidine (75 mg per square meter of body-surface area for 7 days in 28-day cycles) or to receive matched placebo and azacitidine. The primary end point was event-free survival, defined as the time from randomization until treatment failure (i.e., the patient did not have complete remission by week 24), relapse from remission, or death from any cause, whichever occurred first.
The intention-to-treat population included 146 patients: 72 in the ivosidenib-and-azacitidine group and 74 in the placebo-and-azacitidine group. At a median follow-up of 12.4 months, event-free survival was significantly longer in the ivosidenib-and-azacitidine group than in the placebo-and-azacitidine group (hazard ratio for treatment failure, relapse from remission, or death, 0.33; 95% confidence interval CI, 0.16 to 0.69; P = 0.002). The estimated probability that a patient would remain event-free at 12 months was 37% in the ivosidenib-and-azacitidine group and 12% in the placebo-and-azacitidine group. The median overall survival was 24.0 months with ivosidenib and azacitidine and 7.9 months with placebo and azacitidine (hazard ratio for death, 0.44; 95% CI, 0.27 to 0.73; P = 0.001). Common adverse events of grade 3 or higher included febrile neutropenia (28% with ivosidenib and azacitidine and 34% with placebo and azacitidine) and neutropenia (27% and 16%, respectively); the incidence of bleeding events of any grade was 41% and 29%, respectively. The incidence of infection of any grade was 28% with ivosidenib and azacitidine and 49% with placebo and azacitidine. Differentiation syndrome of any grade occurred in 14% of the patients receiving ivosidenib and azacitidine and 8% of those receiving placebo and azacitidine.
Ivosidenib and azacitidine showed significant clinical benefit as compared with placebo and azacitidine in this difficult-to-treat population. Febrile neutropenia and infections were less frequent in the ivosidenib-and-azacitidine group than in the placebo-and-azacitidine group, whereas neutropenia and bleeding were more frequent in the ivosidenib-and-azacitidine group. (Funded by Agios Pharmaceuticals and Servier Pharmaceuticals; AGILE ClinicalTrials.gov number, NCT03173248.).
In order to solve the social phenomenon of difficult employment of college students, this paper constructs a college employment recommendation platform based on an improved collaborative filtering ...algorithm. Firstly, the framework of the employment recommendation system is designed for the user use case, system architecture, system function module, database and user portrait of the platform, respectively. The functional modules are divided into six module parts: campus recruitment management, internship management, employment information management, employment affairs management, employment analysis management, and employment guidance management. Next, the platform is analyzed to combine the recommendation algorithm of collaborative filtering algorithm and clustering technology based on users and items to realize the recommendation of employment information for college students. Then the employment platform is used to get the high stickiness of users in the employment of college students, which can retain about 62% of the number of people, and even 5% of the number of people are particularly fond of the platform. With the increase in recommendation times, the recommendation accuracy increased from 22% to 83%, and the accuracy increased by about 61%, and the comparison with the traditional employment form is much higher than the traditional method in both accuracy and recall rate by about 30%. It is concluded that using the college employment recommendation platform can realize the precise employment of college students.
Nonlinearity is a powerful determinant of physical systems. Controlling nonlinearity leads to interesting states of matter and new applications. In optics, diverse families of continuous and discrete ...states arise from balance of nonlinearity and group-velocity dispersion (GVD). Moreover, the dichotomy of states with locally enhanced or diminished field intensity depends critically on the relative sign of nonlinearity and either anomalous or normal GVD. Here, we introduce a resonator with unconditionally normal GVD and a single defect mode that supports both dark, reduced-intensity states and bright, enhanced-intensity states. We access and explore this dark-to-bright pulse continuum by phase-matching with a photonic-crystal resonator, which mediates the competition of nonlinearity and normal GVD. These stationary temporal states are coherent frequency combs, featuring highly designable spectra and ultralow noise repetition-frequency and intensity characteristics. The dark-to-bright continuum illuminates physical roles of Kerr nonlinearity, GVD, and laser propagation in a gapped nanophotonic medium.
Type-II nodal line semimetal He, Jing; Kong, Xiao; Wang, Wei ...
New journal of physics,
05/2018, Letnik:
20, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Recently, topological semimetals have become a hot topic in condensed matter physics, including Dirac semimetals, Weyl semimetals, and nodal line semimetals (NLSMs). In this paper, a new type of ...NLSM-type-II NLSM-is proposed based on a two-band cubic lattice model. For type-II NLSM, the zero energy bulk states have a closed loop in momentum space but the (local) Weyl cones on the nodal line become tilted. The effect of the magnetic field and that of the correlation on type-II NLSM are studied. In particular, after considering the repulsive interaction and additional spin degrees of freedom, different types of long range magnetic orders appear in bulk states. In addition, the interaction-induced ferromagnetic (FM) order of surface states may exist. At a critical point between type-I NLSM and type-II NLSM, arbitrary tiny interactions induce FM order due to a flat band at the Fermi surface.
Nonlinearity in complex systems leads to pattern formation through fundamental interactions between components. With integrated photonics, precision control of nonlinearity explores novel patterns ...and propels applications. In particular, Kerr-nonlinear resonators support stationary states—including Turing patterns—composed of a few interfering waves, and localized solitons composed of waves across a broad spectrum. Although Turing patterns emerge from an unstable Kerr resonator with sufficiently intense excitation, Kerr solitons do not form spontaneously under constant excitation, making this useful state challenging to access. Here we explore an edgeless photonic crystal resonator (PhCR) that enables spontaneous soliton formation in place of Turing patterns. We design the PhCR nanopattern for single-azimuthal-mode engineering of a group-velocity-dispersion defect that balances Kerr-nonlinear frequency shifts in favour of the soliton state. Our experiments establish PhCR solitons as modelocked pulses through ultraprecise optical-frequency measurements. We show that nanophotonics expand the palette for nonlinear engineering, enabling new phenomena and light sources.Researchers have demonstrated spontaneous soliton formation in an edgeless photonic crystal resonator.
A Highly NIR Emissive Cu16Pd1 Nanocluster Peng, Su‐Kao; Yang, Hu; Luo, Dong ...
Small (Weinheim an der Bergstrasse, Germany),
03/2024, Letnik:
20, Številka:
13
Journal Article
Recenzirano
The construction of stable copper nanoclusters (Cu‐NCs) with near‐infrared (NIR) emission that can be used for catalysis is highly desired, yet remains a challenge. Herein, an atomically precise ...bimetallic Cu/Pd NC with a molecular formula of Cu16Pd1L10(PPh3)2(Pz)6 (Pz = 3,5‐(CF3)2Pyrazolate, L = 4‐CH3OPhC≡C−), abbreviated as Cu16Pd1, is synthesized. Single‐crystal X‐ray crystallographic analysis of Cu16Pd1 reveals a Cu10Pd1 kernel with pseudo‐gyroelongated square bipyramid confirmation surrounded by other 6 Cu(I) ions and protected ligands. Interestingly, it exhibits strong NIR emission with the highest photoluminescence quantum yield (PLQY) among all the Cu NCs/Cu alloys (λem > 800 nm) in the solid‐state, and also displays NIR emission in solution. Experimental results and theoretical calculations suggest that the impressive NIR emission is attributed to abundant supramolecular interactions in the solid‐state, including intramolecular metal–metal and intermolecular interactions. Of note, the bimetallic Cu16Pd1 can catalyze the reduction of 4‐nitrophenol. This work provides a novel method for synthesizing Cu/Pd NCs and reminds that the less studied Cu/Pd NC can serve as outstanding luminescent material, which is seldom noticed in atomically precise nanoclusters.
In this work, an atomically precise bimetallic Cu16Pd1 nanocluster with near‐infrared (NIR) emission both in solution and in solid‐state is synthesized, which is rarely observed in Cu clusters or Cu alloys. Moreover, the Cu16Pd1 nanocluster also displays high catalytic activity for the reduction of 4‐nitrophenol.
Older patients with acute myeloid leukemia (AML) have a dismal prognosis, even after treatment with a hypomethylating agent. Azacitidine added to venetoclax had promising efficacy in a previous phase ...1b study.
We randomly assigned previously untreated patients with confirmed AML who were ineligible for standard induction therapy because of coexisting conditions, because they were 75 years of age or older, or both to azacitidine plus either venetoclax or placebo. All patients received a standard dose of azacitidine (75 mg per square meter of body-surface area subcutaneously or intravenously on days 1 through 7 every 28-day cycle); venetoclax (target dose, 400 mg) or matching placebo was administered orally, once daily, in 28-day cycles. The primary end point was overall survival.
The intention-to-treat population included 431 patients (286 in the azacitidine-venetoclax group and 145 in the azacitidine-placebo control group). The median age was 76 years in both groups (range, 49 to 91). At a median follow-up of 20.5 months, the median overall survival was 14.7 months in the azacitidine-venetoclax group and 9.6 months in the control group (hazard ratio for death, 0.66; 95% confidence interval, 0.52 to 0.85; P<0.001). The incidence of complete remission was higher with azacitidine-venetoclax than with the control regimen (36.7% vs. 17.9%; P<0.001), as was the composite complete remission (complete remission or complete remission with incomplete hematologic recovery) (66.4% vs. 28.3%; P<0.001). Key adverse events included nausea of any grade (in 44% of the patients in the azacitidine-venetoclax group and 35% of those in the control group) and grade 3 or higher thrombocytopenia (in 45% and 38%, respectively), neutropenia (in 42% and 28%), and febrile neutropenia (in 42% and 19%). Infections of any grade occurred in 85% of the patients in the azacitidine-venetoclax group and 67% of those in the control group, and serious adverse events occurred in 83% and 73%, respectively.
In previously untreated patients who were ineligible for intensive chemotherapy, overall survival was longer and the incidence of remission was higher among patients who received azacitidine plus venetoclax than among those who received azacitidine alone. The incidence of febrile neutropenia was higher in the venetoclax-azacitidine group than in the control group. (Funded by AbbVie and Genentech; VIALE-A ClinicalTrials.gov number, NCT02993523.).
ESG (Environmental, Social, and Governance) performance is necessary to establish sustainable corporations. As the scale effect of the market application of low-carbon technologies is yet to be ...realised, China’s enterprises may find it difficult to balance their environmental (low-carbon transition) and social (increase in wages) responsibilities, and are caught in a governance dilemma. Therefore, in order to test the above hypotheses, we utilised the staggered difference-in-differences method to investigate the wage effects of low-carbon transformations. The results are displayed as follows. First, the low-carbon transition constraint initially increases firms’ labour demand and reduces energy consumption, leading to lower productivity and thus negatively affecting firms’ wages, even though the low-carbon transition can promote internal equity. Second, the impact of the policy on wages is heterogeneous. It has a more pronounced negative impact on enterprise wages in state-owned enterprises, old enterprises, primary and secondary industry enterprises, and low-carbon enterprises, whereas its promoting effect on internal fairness within old enterprises, secondary industry enterprises, and low-carbon enterprises is more significant. Finally, the negative impact of low-carbon policies on corporate wages gradually decreases while strengthening the promoting effect on the internal fairness of employee remuneration. The above results confirm that at this stage, when China’s enterprises are pursuing the environmental goal of low-carbon transition, it will affect their efficiency in the short term, which in turn will lead to lower wages. Moreover, this problem is too difficult to be solved by enterprises alone and requires assistance from the government. Under the ESG concepts, we provide insights into how to coordinate policies to improve living standards and promote low-carbon transformations.
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