Budget restrictions have forced the ITER Organization to reconsider the baseline divertor strategy, in which operations would begin with carbon (C) in the high heat flux regions, changing out to a ...full-tungsten (W) variant before the first nuclear campaigns. Substantial cost reductions can be achieved if one of these two divertors is eliminated. The new strategy implies not only that ITER would start-up on a full-W divertor, but that this component should survive until well into the nuclear phase. This paper considers the risks engendered by such an approach with regard to known W plasma-material interaction issues and briefly presents the current status of a possible full-W divertor design.
•Detailed design development plan for the ITER tungsten divertor.•Latest status of the ITER tungsten divertor design.•Brief overview of qualification program for the ITER tungsten divertor and status ...of R&D activity.
In November 2011, the ITER Council has endorsed the recommendation that a period of up to 2 years be set to develop a full-tungsten divertor design and accelerate technology qualification in view of a possible decision to start operation with a divertor having a full-tungsten plasma-facing surface. To ensure a solid foundation for such a decision, a full tungsten divertor design, together with a demonstration of the necessary high performance tungsten monoblock technology should be completed within the required timescale. The status of both the design and technology R&D activity is summarized in this paper.
In Asians, the risk of irinotecan-induced severe toxicities is related in part to UGT1A1*6 (UGT, UDP glucuronosyltransferase) and UGT1A1*28, variant alleles that reduce the elimination of SN-38, the ...active metabolite of irinotecan. We prospectively studied the relation between the UGT1A1 genotype and the safety of irinotecan-based regimens in Japanese patients with advanced colorectal cancer, and then constructed a nomogram for predicting the risk of severe neutropenia in the first treatment cycle.
Safety data were obtained from 1312 patients monitored during the first 3 cycles of irinotecan-based regimen in a prospective observational study. In development of the nomogram, multivariable logistic regression analysis was used to test the associations of candidate factors to severe neutropenia in the first cycle. The final nomogram based on the results of multivariable analysis was constructed and validated internally using a bootstrapping technique and externally in an independent data set (n=350).
The UGT1A1 genotype was confirmed to be associated with increased risks of irinotecan-induced grade 3 or 4 neutropenia and diarrhoea. The final nomogram included type of regimen, administered dose of irinotecan, gender, age, UGT1A1 genotype, Eastern Cooperative Oncology Group performance status, pre-treatment absolute neutrophil count, and total bilirubin level. The model was validated both internally (bootstrap-adjusted concordance index, 0.69) and externally (concordance index, 0.70).
Our nomogram can be used before treatment to accurately predict the probability of irinotecan-induced severe neutropenia in the first cycle of therapy. Additional studies should evaluate the effect of nomogram-guided dosing on efficacy in patients receiving irinotecan.
Some of the remaining crucial plasma edge physics and plasma–material interaction issues of the ITER tokamak are discussed in this paper, using either modelling or projections of experimental results ...from existing tokamak operation or relevant laboratory simulations. The paper covers the following subject areas at issue in the design of the ITER device: (1) plasma thermal loads during Type I ELMs and disruptions, ensuing erosion effects and prospects for mitigating measures, (2) control of co-deposited tritium inventory when carbon is used even on small areas in the divertor near the strike points, (3) efficiency of edge and core fuelling for expected pedestal densities in ITER, and (4) erosion and impurity transport with a full tungsten divertor. Directions and priorities of future research are proposed to narrow remaining uncertainties in the above areas.
To evaluate the effect of intratympanic steroid injection frequency on hearing outcomes for patients with idiopathic sudden sensorineural hearing loss.
A retrospective chart review was performed from ...2007 to 2015 at a neurotology tertiary referral center. Adults who met academy criteria for idiopathic sudden sensorineural hearing loss within two months of onset and negative imaging were grouped based on injection frequency. Injection schedules were every 1–4 (group 1), 5–10 (group 2), or 11–30 (group 3) days. All patients had at least two injections with Dexamethasone 10 mg/ml. All patients had pre- and post-injection audiograms.
Seventy patients met inclusion criteria (group 1, n = 21; group 2, n = 29; group 3, n = 20). There was no significant difference between group demographics or baseline audiometric data. Mean gains were significant and similar between groups for pure tone average (group 1 = −23.6 ± 22.0 dB; group 2 = −19.7 ± 18.4 dB; group 3 = −24.9 ± 24.7 dB; p = 0.67) and word recognition score (group 1 = +26.3 ± 34.8%; group 2 = +23.3 ± 29.9%; group 3 = +33.4 ± 28.9%; p = 0.53).
Frequency of intratympanic steroid injections does not significantly affect hearing outcomes. Following injection therapy, hearing outcomes improved regardless of prior or concomitant oral steroid regimen. Earlier time to initiating injections yielded a higher rate of hearing improvement. Long term hearing outcomes >6 months did not show significant additional improvement.
Thermoplastic injection molding is applied in a wide variety of products. It is known that volatile components generated when resin melts cause structural defects during the thermoplastic injection ...process. Not only that, the pre-injection preparation work including drying the material and maintaining the metal mold, have become standard procedures to prevent these defects, but these procedures deteriorate productivity. Vent-type injection molding involves the use of cylinders featuring a vent hole at the center of the plasticizing cylinder. Although it is a conventional molding method, there are many issues including resin leakage from a vent hole and difficulty of material replacements. These issues prevented it from widespread application. Moreover, the vent-type plasticization process has not been examined theoretically or systematically. In order to maximize and generalize functions of vent-type molding, it is necessary to clarify the flow behavior of resin in the vent cylinder. In this study, we verified the flow behavior of resin in the vent-type plasticization cylinder through experimentation and simulation. In the simulation, using the flow analysis method, the filling rate inside the screw was determined by the pressure distribution inside the screw. In the experiments, the molding condition that causes venting up was verified by changing the screw rotation rates and the supply amount of the resin, for determining the filling rate of resin inside the screw. The filling rates obtained through the simulation and the experiment are almost the same. The result suggests that this simulation is very effective for predicting the filling rate.
AN EXPERIMENTAL STUDY OF PAPER FLUTTER WATANABE, Y.; SUZUKI, S.; SUGIHARA, M. ...
Journal of fluids and structures,
05/2002, Letnik:
16, Številka:
4
Journal Article
Recenzirano
An experimental study was conducted in order to clarify the phenomenon of paper flutter. Flutter speed was measured in wind tunnel tests for sheet paper and web paper of various materials, sizes and ...tensions. The relationships between flutter speed, rigidity, mass ratio and tension were clarified from a large data set. The flutter boundaries were obtained in the form of dimensionless flutter speed and mass ratio for the case of sheet paper, and dimensionless flutter speed, mass ratio and tension parameter for the case of web paper. The flutter mode and air-flow around fluttering paper were investigated by visualization tests.
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