In this study, a corpus of essays stratified by level (9th grade, 11th grade, and college freshman) are analyzed computationally to discriminate differences between the linguistic features produced ...in essays by adolescents and young adults. The automated tool Coh-Metrix is used to examine to what degree essays written at various grade levels can be distinguished from one another using a number of linguistic features related to lexical sophistication (i.e., word frequency, word concreteness), syntactic complexity (i.e., the number of modifiers per noun phrase), and cohesion (i.e., word overlap, incidence of connectives). The analysis demonstrates that high school and college writers develop linguistic strategies as a function of grade level. Primarily, these writers produce more sophisticated words and more complex sentence structure as grade level increases. In contrast, these writers produce fewer cohesive features in text as a function of grade level. This analysis supports the notion that linguistic development occurs in the later stages of writing development and that this development is primarily related to producing texts that are less cohesive and more elaborate.
There is increased interest in faith-based social service provision in recent years, both in the United States and across Europe. While faith-based organizations provide welcome and needed services, ...there are several potential problems of social inclusion which involve gender, including decreased availability of social services when faith-based organizations are expected to compensate for cuts in government spending, potential for religious discrimination in employment, and potential for religious discrimination against recipients.
Sickle cell disease (SCD) is a hemoglobinopathy that causes debilitating pain. Patients often report dissatisfaction during care seeking for pain or a sickle cell crisis (SCC). The Theory of ...Self-Care Management for SCD conceptualizes assertive communication as a self-care management resource that improves healthcare outcomes.
This pilot study aimed to determine whether adults with SCD could learn to use the Situation, Background, Assessment, Recommendation (SBAR) communication method using a web-based trainer, and it aimed to determine their perceptions of the training.
The participants included
= 18 adults with SCD. Inter-rater reliability (IRR) among three reviewers was used to evaluate the participants' ability to respond as expected to prompts using SBAR communication within the web-based platform. Content analysis was used to describe the participants' perspectives of the acceptability of using the SBAR patient-HCP communication simulation.
The SBAR IRR ranged from 64 to 94%, with 72% to 94% of the responses being evaluated as the using of the SBAR component as expected. The predominant themes identified were (1) Patient-Provider Communication and Interaction; (2) Patients want to be Heard and Believed; (3) Accuracy of the ED Experience and Incorporating the Uniqueness of each Patient; and (4) the Overall Usefulness of the Video Trainer emerging.
This pilot study supported the usefulness and acceptability of a web-based intervention in training adults with SCD to use SBAR to enhance patient-HCP communication. Enhancing communication may mitigate the barriers that individuals with SCD encounter during care seeking and improve the outcomes. Additional studies with larger samples need to be conducted.
While previous research confirms the role religion can play in positive youth development, much existing research leaves out consideration of underrepresented populations. One important ...underrepresented population is children and youth with autism spectrum disorder (ASD), which now impacts one in 59 children in the United States. Using qualitative data collected from in depth, semi-structured, face-to-face interviews of 53 parents/caregivers, in this article, we analyze barriers and opportunities in religious education for children and youth with autism spectrum disorder. We analyze factors impacting whether parents perceive their children to have a supportive and appropriate religious education experience or an unsupportive and alienating experience. We also provide recommendations for congregations and argue for inclusion of children with autism spectrum disorder in future research on religion and positive youth development.
The T2Rs belong to a multi-gene family of G-protein-coupled receptors responsible for the detection of ingested bitter-tasting compounds. The T2Rs are conserved among mammals with the human and mouse ...gene families consisting of about 25 members. In the present study we address the signalling properties of human and mouse T2Rs using an in vitro reconstitution system in which both the ligands and G-proteins being assayed can be manipulated independently and quantitatively assessed. We confirm that the mT2R5, hT2R43 and hT2R47 receptors respond selectively to micromolar concentrations of cycloheximide, aristolochic acid and denatonium respectively. We also demonstrate that hT2R14 is a receptor for aristolochic acid and report the first characterization of the ligand specificities of hT2R7, which is a broadly tuned receptor responding to strychnine, quinacrine, chloroquine and papaverine. Using these defined ligand-receptor interactions, we assayed the ability of the ligand-activated T2Rs to catalyse GTP binding on divergent members of the G(alpha) family including three members of the G(alphai) subfamily (transducin, G(alphai1) and G(alphao)) as well as G(alphas) and G(alphaq). The T2Rs coupled with each of the three G(alphai) members tested. However, none of the T2Rs coupled to either G(alphas) or G(alphaq), suggesting the T2Rs signal primarily through G(alphai)-mediated signal transduction pathways. Furthermore, we observed different G-protein selectivities among the T2Rs with respect to both G(alphai) subunits and G(betagamma) dimers, suggesting that bitter taste is transduced by multiple G-proteins that may differ among the T2Rs.
Taste receptors cells are responsible for detecting a wide variety of chemical stimuli. Several molecules including both G protein coupled receptors and ion channels have been shown to be involved in ...the detection and transduction of tastants. We report on the expression of two members of the transient receptor potential (TRP) family of ion channels, PKD1L3 and PKD2L1, in taste receptor cells. Both of these channels belong to the larger polycystic kidney disease (PKD or TRPP) subfamily of TRP channels, members of which have been demonstrated to be non‐selective cation channels and permeable to both Na+ and Ca2+. Pkd1l3 and Pkd2l1 are co‐expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer. We found the taste receptor cells expressing Pkd1l3 and Pkd2l1 to be distinct from those that express components of sweet, bitter and umami signal transduction pathways. These results provide the first evidence for a role of TRPP channels in taste receptor cell function.
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