NESCA, a newly discovered signaling adapter protein in the NGF-pathway, contains a RUN domain at its N-terminus. Here we report the crystal structure of the NESCA RUN domain determined at 2.0-Å ...resolution. The overall fold of the NESCA RUN domain comprises nine helices, resembling the RUN domain of RPIPx and the RUN1 domain of Rab6IP1. However, compared to the other RUN domains, the RUN domain of NESCA has significantly different surface electrostatic distributions at the putative GTPase-interacting interface. We demonstrate that the RUN domain of NESCA can bind H-Ras, a downstream signaling molecule of TrkA, with high affinity. Moreover, NESCA RUN can directly interact with TrkA. These results provide new insights into how NESCA participates in the NGF-TrkA signaling pathway.
To evaluate the impact of RA on work capacity and identify factors related to work capacity impairment in patients with RA.
A cross-sectional multicentre study was performed in 21 tertiary care ...hospitals across China. A consecutive sample of 846 patients with RA was recruited, of which 589 patients of working age at disease onset constituted the study population. Information on the socio-demographic, clinical, working and financial conditions of the patients was collected. Logistic regression analyses were used to identify factors associated with work capacity impairment.
The rate of work capacity impairment was 48.0% in RA patients with a mean disease duration of 60 months (interquartile range 14-134 months), including 11.7% leaving the labour force early, 33.6% working reduced hours and 2.7% changing job. Multivariable logistic regression analysis showed that reduced working hours was significantly related to current smoking odds ratio (OR) 2.07 (95% CI 1.08, 3.97), no insurance OR 1.94 (95% CI 1.20, 3.12), in manual labour OR 2.66 (95% CI 1.68, 4.20) and higher HAQ score OR 2.22 (95% CI 1.36, 3.60). There was an association of current smoking OR 3.75 (95% CI 1.54, 9.15), in manual labour OR 2.33 (95% CI 1.17, 4.64), longer disease duration OR 1.01 (95% CI 1.00, 1.01) and lower BMI OR 0.90 (95% CI 0.82, 0.99) with leaving the labour force early.
There is a substantial impact of RA on the work capacity of patients in China. Social-demographic, disease- and work-related factors are all associated with work capacity impairment.
To investigate the expression of microRNA-128a (miR-128a) and its role in hepatocellular carcinoma (HCC).
Nineteen pairs of fresh surgical specimens of HCC and adjacent tissues were examined for ...miR-128a expression using qRT-PCR. A miR-128a mimics or inhibitor was transfected into HCC cells, and the cell viability was analyzed by MTT assay. RND3, one of the potential targets of miR-128a, was predicted by bioinformatics software and demonstrated by dual luciferase reporter assay. The expression of RND3 after transfection was detected using qRT-PCR and Western blotting, and the cell cycle-related proteins were determined with Western blotting.
The expression of miR-128a were significantly up-regulated in HCC tissues as compared to the adjacent tissues (P<0.05). In cultured HCC cells, miR-128a promoted the cell proliferation and resulted in down-regulated RND3 mRNA and protein expressions by targeting RND3' 3'UTR (P<0.05) and also in the down-regulation of cyclin B1, cyclin D1 and CDK4 protein expressions.
miR-1
In the downlink transmission, the legitimate users are also vulnerable to malicious jamming when the desired signal is launched by multiple antenna array. Then, this paper investigates an ...anti-jamming defense criteria through a deep reinforcement learning (DRL) to suppress the jamming at transmitting information. Firstly, a dual-polarized antenna array is designed to achieve the global positioning system (GPS) signals model, and the information of designed model can be directly used into the anti-jamming criteria more general. Then, we set up the preprocessing framework based on a cyclic convolutional neural network (CNN), which is used to preprocesses the objective function by approximating the evaluated variable to the target value, i.e., the dynamic objective function of beamforming. Subsequently, a DRL algorithm based on the deep Q-network is proposed to achieve the optical null-steering strategy in dynamic jamming environment. Finally, some simulation results validate the proposed DRL can effectively improve both the system sum-rate and combating dynamic jamming level compared with other approaches.
A new mesoporous sphere‐like SBA‐15 silica was synthesized and evaluated in terms of its suitability as stationary phases for CEC. The unique and attractive properties of the silica particle are its ...submicrometer particle size of 400 nm and highly ordered cylindrical mesopores with uniform pore size of 12 nm running along the same direction. The bare silica particles with submicrometer size have been successfully employed for the normal‐phase electrochromatographic separation of polar compounds with high efficiency (e.g., 210 000 for thiourea), which is matched well with its submicrometer particle size. The Van Deemeter plot showed the hindrance to mass transfer because of the existence of pore structure. The lowest plate height of 2.0 μm was obtained at the linear velocity of 1.1 mm/s. On the other hand, because of the relatively high linear velocity (e.g., 4.0 mm/s) can be generated, high‐speed separation of neutral compounds, anilines, and basic pharmaceuticals in CEC with C18‐modified SBA‐15 silica as stationary phases was achieved within 36, 60, and 34 s, respectively.
Two‐dimensional (2D) metallic transition‐metal dichalcogenides (TMDCs), such as 1T‐TiSe2, have recently emerged as unique platforms for exploring their exciting properties of superconductivity and ...the charge density wave (CDW). 2D 1T‐TiSe2 undergoes rapid oxidation under ambient conditions, significantly affecting its CDW phase‐transition behavior. We comprehensively investigate the oxidation process of 2D TiSe2 by tracking the evolution of the chemical composition and atomic structure with various microscopic and spectroscopic techniques and reveal its unique selenium‐assisting oxidation mechanism. Our findings facilitate a better understanding of the chemistry of ultrathin TMDCs crystals, introduce an effective method to passivate their surfaces with capping layers, and thus open a way to further explore the functionality of these materials toward devices.
Das Oxidationsverhalten und der Effekt der Oxidation auf das Phasenübergangsverhalten der Ladungsdichtewellen in 2D‐TiSe2 wurden untersucht (siehe Bild; Ti violett, Se gelb, O blau). Die Ergebnisse bieten Einblick in den Oxidationsmechanismus ultradünner Schichtmaterialien und ebnen den Weg für die Nutzung der ungewöhnlichen Eigenschaften dieser Materialien.
Abstract
Two‐dimensional (2D) metallic transition‐metal dichalcogenides (TMDCs), such as 1
T
‐TiSe
2
, have recently emerged as unique platforms for exploring their exciting properties of ...superconductivity and the charge density wave (CDW). 2D 1
T
‐TiSe
2
undergoes rapid oxidation under ambient conditions, significantly affecting its CDW phase‐transition behavior. We comprehensively investigate the oxidation process of 2D TiSe
2
by tracking the evolution of the chemical composition and atomic structure with various microscopic and spectroscopic techniques and reveal its unique selenium‐assisting oxidation mechanism. Our findings facilitate a better understanding of the chemistry of ultrathin TMDCs crystals, introduce an effective method to passivate their surfaces with capping layers, and thus open a way to further explore the functionality of these materials toward devices.
Two-dimensional (2D) metallic transition-metal dichalcogenides (TMDCs), such as 1T-TiSe
, have recently emerged as unique platforms for exploring their exciting properties of superconductivity and ...the charge density wave (CDW). 2D 1T-TiSe
undergoes rapid oxidation under ambient conditions, significantly affecting its CDW phase-transition behavior. We comprehensively investigate the oxidation process of 2D TiSe
by tracking the evolution of the chemical composition and atomic structure with various microscopic and spectroscopic techniques and reveal its unique selenium-assisting oxidation mechanism. Our findings facilitate a better understanding of the chemistry of ultrathin TMDCs crystals, introduce an effective method to passivate their surfaces with capping layers, and thus open a way to further explore the functionality of these materials toward devices.
The inorganic-organic hybrid junction was synthesized on ITO glass substrate, which was consisted of an n-type ZnO nanorods （NRs） grown by low-temperature aqueous chemical growth method and a p-type ...polyfluorene （PF） organic film fabricated by spin-coating. The experimental results indicate that densely and uniformly distributed ZnO nanorods are successfully grown on the PF layer. The thickness of the PF layer plays a dominant role for the current-voltage （I-V） characteristic of the ZnO NRs/PF inorganic-organic hybrid junction device, and a p-n junction with obviously rectifying behavior is achieved with optimal PF layer thickness. The photoluminescence （PL） spectrum covering the broad visible range was obtained from the n-ZnO nanorods/p-polyfluorene （PF） structure, which was originated from the combination of the PF-related blue emission and the ZnO-related deep level emission.
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