Abstract
Invasive electrical stimulation (iES) is prone to cause neural stimulus-inertia owing to its excessive accumulation of exogenous charges, thereby resulting in many side effects and even ...failure of nerve regeneration and functional recovery. Here, a wearable neural iES system is well designed and built for bionic and long-lasting neural modulation. It can automatically yield biomimetic pulsed electrical signals under the driven of respiratory motion. These electrical signals are full of unique physiological synchronization can give biofeedback to respiratory behaviors, self-adjusting with different physiological states of the living body, and thus realizing a dynamic and biological self-matched modulation of voltage-gated calcium channels on the cell membrane. Abundant cellular and animal experimental evidence confirm an effective elimination of neural stimulus-inertia by these bioelectrical signals. An unprecedented nerve regeneration and motor functional reconstruction are achieved in long-segmental peripheral nerve defects, which is equal to the gold standard of nerve repair -- autograft. The wearable neural iES system provides an advanced platform to overcome the common neural stimulus-inertia and gives a broad avenue for personalized iES therapy of nerve injury and neurodegenerative diseases.
The volcanic activity of the Xiong’er Group and its concomitant sedimentation are related to the stretching–breakup of the Columbia supercontinent. The Dagushi Formation overlies the Paleoproterozoic ...Shuangfang Formation with an angular unconformity. The Dagushi Formation, as the earliest clastic strata of the Xiong’er Group and the first stable sedimentary cover overlying the Archean crystalline basement in the southern margin of the North China Craton, provides tectonic evolution information that predates Xiong’er volcanic activity. By distinguishing lithologic characteristics and sedimentary structures, we identified that the sedimentary facies of the Dagushi Formation were braided river delta lake facies from bottom to top. The U–Pb ages of the detrital zircons of the Dagushi Formation can be divided into four groups: ~1905–1925, ~2154–2295, ~2529–2536, and ~2713–2720 Ma, indicating the provenance from the North China Craton basement. Based on the geochemical characteristics of the Dagushi Formation, we suggest that the sediments accumulated rapidly near the source, which were principally felsic in nature, and were supplemented by recycled materials. The provenance area pointed to the underlying metamorphic crystalline basement of the North China Craton as the main source area with an active tectonic background. The Chemical Index of Alteration (CIA) values of the Dagushi Formation sandstone samples ranged from 60.8 to 76.7, indicating that the source rocks suffered from slight to moderate chemic chemical weathering. The Index of Composition Variability (ICV) values ranged from 0.8 to 1.3, which indicates the first cyclic sediments. The vertical facies and provenance changes of the Dagushi Formation reflect a continuous crust fracturing process that occurred in the North China Craton.
The diagnosis of cervical spondylotic myelopathy (CSM) relies on several methods, including x-rays, computed tomography, and magnetic resonance imaging (MRI). Although MRI is the most useful ...diagnostic tool, strategies to improve the precise and independent diagnosis of CSM using novel MRI imaging techniques are urgently needed. This study aimed to explore potential brain biomarkers to improve the precise diagnosis of CSM through the combination of voxel-based morphometry (VBM) and tensor-based morphometry (TBM) with machine learning techniques.
In this retrospective study, 57 patients with CSM and 57 healthy controls (HCs) were enrolled. The structural changes in the gray matter volume and white matter volume were determined by VBM. Gray and white matter deformations were measured by TBM. The support vector machine (SVM) was used for the classification of CSM patients from HCs based on the structural features of VBM and TBM.
CSM patients exhibited characteristic structural abnormalities in the sensorimotor, visual, cognitive, and subcortical regions, as well as in the anterior corona radiata and the corpus callosum
< 0.05, false discovery rate (FDR) corrected. A multivariate pattern classification analysis revealed that VBM and TBM could successfully identify CSM patients and HCs classification accuracy: 81.58%, area under the curve (AUC): 0.85;
< 0.005, Bonferroni corrected through characteristic gray matter and white matter impairments.
CSM may cause widespread and remote impairments in brain structures. This study provided a valuable reference for developing novel diagnostic strategies to identify CSM.
The Upper Paleozoic coal-measure strata in the Western Henan has good unconventional oil and gas exploration prospects. However, there is a lack of systematic evaluation of potential source rocks. ...Aiming at the fully exposed the coring boreholes in the Upper Paleozoic in the Western Henan (Luoyang Basin), this paper systematically collects and analyzes samples. Considering the sedimentary environmental conditions, this paper evaluates the Upper Paleozoic source rocks in the Western Henan. The results show that the source rocks include mudstone, carbonate rocks, and coal rocks; Vertically, the source rocks are continuously distributed in the lower layer below the Dazhan sandstone of Shanxi Formation, and only locally developed above Dazhan sandstone; The organic matter type of coal and mudstone is type III, and the kerogen type of carbonate rocks is also type III, which is different from the organic matter type of general carbonate rocks (type I), which is related to the sedimentary environment. The average value of vitrinite reflectance is more than 4.27% and the average value of maximum pyrolysis temperature is more than 430 °C. The thermal evolution degree of source rocks reached the mature to over-mature stage, which tends to gradually increase with the increase of depth, which may be related to Meso–Cenozoic tectonothermal events.
The bauxite layer in Western Henan supplies a large number of bauxite ores and is useful for studying tectonic movement. In this paper, the bauxite samples were selected to carry out LA-ICP-MS ...detrital zircons U-Pb dating and Hf isotope testing. The results indicated that the detrital zircons with the Early Paleozoic ages were mainly derived from the North Qinling Orogenic Belt. The detrital zircons of the Precambrian age may be derived mainly from the basement of the North China Block and the North Qinling Orogenic Belt. The results of this study support the opinion that the North Qinling Orogenic Belt has been uplifted at ~310 Ma, and the surface of the southern craton has an overall north-dipping topography at this time.
The Upper Paleozoic coal measure strata in the Southern North China Basin have good potential for unconventional oil and gas exploration. However, there has been no systematic evaluation of potential ...source rock in this area; this affects the estimation of potential resources and the choice of exploratory target layers. In this study, full core holes ZK0901 and ZK0401, which perfectly reveal Upper Paleozoic strata in the study area, systematically collected and analyzed the samples for total organic carbon, rock pyrolysis, chloroform bitumen “A,” organic maceral, vitrinite reflectance, and kerogen carbon isotopes. The results showed that in addition to coal rocks, mudstones and carbonate rocks are also potential source rocks in the Upper Paleozoic strata. Vertically, the source rocks are continuous in Taiyuan Formation, the lower part of Shanxi Formation, and Lower Shihezi Formation. The organic matter type in the Upper Paleozoic coal rocks and mudstone source rock belong to type III or II. This phenomenon is mainly attributed to the special transgressive–regressive sedimentary environment of the carbonate rocks. The higher degree of thermal evolution in the Upper Paleozoic source rocks may be related to the structure or a higher paleogeothermal gradient in this area. The coal layer and its upper and lower mudstone of the Shanxi Formation and Lower Shihezi Formation are the main target layers of unconventional oil and gas exploration. The results from this study can be used as a reference for the study on potential source rock for unconventional oil and gas exploration in the Southern North China Basin.
The Upper Paleozoic strata in Southwestern Henan have good prospects for unconventional oil and gas exploration. This paper takes the Upper Paleozoic source rocks in the Yuzhou area and the ...Pingdingshan area in Southwestern Henan as the research object, and tests 107 samples from the Upper Paleozoic coal rock, mudstone and carbonate rock. Combined with the sedimentary environment background, the Upper Paleozoic source rocks in Southwestern Henan are comprehensively evaluated. The results show that the Upper Paleozoic source rocks in Southwestern Henan, including coal rocks, mudstone and carbonate rocks, can be used as potential source rocks. Vertically, the source rocks are continuously distributed in the lower layer below the sandstone of Shanxi Formation. The Dazhan sandstone is only locally developed; the distribution of Upper Paleozoic source rocks in Southwestern Henan is mainly related to the Late Paleozoic transgression.
Polyoxymethylene dimethyl ether (PODEn) is a promising diesel additive, especially in particulate matter reduction. However, how PODEn addition affects the filtration efficiency and regeneration ...process of a catalytic diesel particulate filter (cDPF) is still unknown. Therefore, this experimental work investigated the size-dependent particulate number removal efficiency under various engine loads and exhaust gas recirculation (EGR) ratios when fueling with diesel (D100) and diesel/PODEn mixture (P10). In addition, the regeneration behavior of the cDPF was studied by determining the breakeven temperatures (BETs) for both tested fuels. The results showed that the cDPF had lower removal efficiencies in nucleation mode particles but higher filtration efficiencies in accumulation mode particles. In addition, the overall filtration efficiency for P10 particles was higher than that for D100 particles. Positioning the upstream cDPF, increasing the EGR ratio slightly decreased the number concentration of nucleation mode particles but greatly increased that of accumulation mode particles. However, increasing the EGR ratio decreased the removal efficiency of nanoparticles, and this effect was more apparent for the P10 case. Under the same period of soot loading, the pressure drop of P10 fuel was significantly lower than that of diesel fuel. In addition, a significantly lower BET was observed for the P10 fuel, in comparison with D100 fuel. In conclusion, adopting cDPF is beneficial for fueling with P10 in terms of the overall filtration efficiency in the particulate number and the lower input energy requirement for active regeneration. However, with the addition of EGR, the lower filtration efficiencies of nanoparticles should be concerned, especially fueling with diesel/PODEn mixture.
Novel phase-locked acceleration of a relativistic isolated attosecond electron sheet was realized using a relativistic reflected spatiotemporal optical vortex (STOV) pulse in three-dimensional ...particle-in-cell simulations. Electrons can be trapped in a spatiotemporal phase singularity within the STOV pulse center, modulated into an approximately 600-attosecond duration sheet. Furthermore, electrons can be phase-locked accelerated to the order of GeV in the longitudinal direction. Such an isolated attosecond electron sheet driven by the intense STOV pulse can be used in isolated attosecond pulse generation, ultrashort x/γ-ray radiation, and attosecond electron diffraction.
We investigated the association of ankle-brachial blood pressure index (ABI), interarm blood pressure (BP) difference and interankle BP difference, obtained by simultaneous four-limb BP measurement, ...with history of stroke in a Chinese adult population.
This cross-sectional study included 1485 participants aged ≥35 years in the framework of the China Hypertension Survey. We performed simultaneous four-limb BP measurement using oscillometric devices with the participants in the supine position and calculated ABI and interarm/interankle BP differences between the 4 limbs. Logistic regression analysis was used to estimate the association of these BP parameters and other factors with a history of stroke.
In univariate analyses, participants with ABI <0.9, interarm BP difference ≥15 mmHg, and interankle BP difference ≥10 mmHg had a higher prevalence of stroke than those without (p < 0.0001, p = 0.0152, p = 0.002, respectively). Multiple logistic regression analyses suggested, ABI <0.9 was independently associated with a history of stroke after adjustment for interarm BP difference ≥15 mmHg, interankle BP difference ≥10 mmHg, and traditional risk factors for stroke (p = 0.001). An interankle BP difference ≥10 mmHg was associated with prior stroke after the two variables of hypertension and ABI were removed from the logistic regression model (p = 0.0142). Net reclassification improvement analysis showed that inclusion of interankle BP difference ≥10 mmHg to the independent risk factors (age, family history of stroke, hypertension, and ABI) improved net reclassification by 11.92%.
ABI <0.9 is an independent risk factor for stroke prevalence in Chinese adults and it just detected a small propotion of paticipants. The addition of interankle BP difference ≥10 mmHg to the independent risk factors for stroke may improve the prediction of stroke.
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