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zadetkov: 29
1.
  • From circuits to behavior: ... From circuits to behavior: Amygdala dysfunction in fragile X syndrome
    Svalina, Matthew N; Sullivan, Regina; Restrepo, Diego ... Frontiers in integrative neuroscience, 03/2023, Letnik: 17
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    Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the gene resulting in transcriptional silencing and loss of function of ...
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  • Functionally defined therap... Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
    Grasso, Catherine S; Tang, Yujie; Truffaux, Nathalene ... Nature medicine, 06/2015, Letnik: 21, Številka: 6
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    Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling ...
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3.
  • EphB4/EphrinB2 therapeutics... EphB4/EphrinB2 therapeutics in Rhabdomyosarcoma
    Randolph, Matthew E; Cleary, Megan M; Bajwa, Zia ... PloS one, 08/2017, Letnik: 12, Številka: 8
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    Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma affecting children and is often diagnosed with concurrent metastases. Unfortunately, few effective therapies have been discovered that ...
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4.
  • YAPping About Differentiati... YAPping About Differentiation Therapy in Muscle Cancer
    Svalina, Matthew N.; Keller, Charles Cancer cell, 08/2014, Letnik: 26, Številka: 2
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    Overcoming a presumed differentiation block in the childhood muscle cancer embryonal rhabdomyosarcoma is often thought to hold promise as an approach to replace cytotoxic chemotherapy with ...
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5.
  • IL-13 receptors as possible... IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma
    Berlow, Noah E; Svalina, Matthew N; Quist, Michael J ... PloS one, 04/2018, Letnik: 13, Številka: 4
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    Diffuse intrinsic pontine glioma (DIPG) is a universally fatal childhood cancer of the brain. Despite the introduction of conventional chemotherapy and radiotherapy, improvements in survival have ...
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6.
  • Basolateral Amygdala Hypere... Basolateral Amygdala Hyperexcitability Is Associated with Precocious Developmental Emergence of Fear-Learning in Fragile X Syndrome
    Svalina, Matthew N; Rio, Christian A Cea-Del; Kushner, J Keenan ... The Journal of neuroscience, 2022-Sep-21, 2022-09-21, 20220921, Letnik: 42, Številka: 38
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    Fragile X Syndrome is a neurodevelopmental disorder and the most common monogenic cause of intellectual disability, autism spectrum disorders, and anxiety disorders. Loss of fragile x mental ...
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7.
  • The HDAC3-SMARCA4-miR-27a a... The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma
    Bharathy, Narendra; Berlow, Noah E; Wang, Eric ... Science signaling, 11/2018, Letnik: 11, Številka: 557
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    Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with an unmet clinical need for decades. A single oncogenic fusion gene is associated with treatment resistance and a 40 to ...
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8.
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9.
  • Probabilistic modeling of p... Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma
    Berlow, Noah E; Rikhi, Rishi; Geltzeiler, Mathew ... BMC cancer, 06/2019, Letnik: 19, Številka: 1
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    Cancer patients with advanced disease routinely exhaust available clinical regimens and lack actionable genomic medicine results, leaving a large patient population without effective treatments ...
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10.
  • NFκB signaling in alveolar ... NFκB signaling in alveolar rhabdomyosarcoma
    Cleary, Megan M; Mansoor, Atiya; Settelmeyer, Teagan ... Disease models & mechanisms, 09/2017, Letnik: 10, Številka: 9
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    Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the ...
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zadetkov: 29

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