Aggressive periodontitis (AgP), a severe and early onset type of periodontitis, is thought to be subject to significant genetic background effects. Formyl peptide receptor 1 (FPR1) is a gene strongly ...implicated in AgP. To determine whether variations in this gene are associated with AgP, we performed an association study with 49 AgP patients and 373 controls using 30 variations identified by sequencing the 21.1-kb gene region. Five polymorphisms (−12915C
>
T, −10056T
>
C, −8430A
>
G, 301G
>
C, and 546C
>
A) showed significant association with AgP. Polymorphonuclear neutrophils from subjects carrying the −12915T allele expressed significantly lower levels of
FPR1 transcripts than those homozygous for the −12915C allele. Furthermore, the −12915T allele decreased activity of transcriptional regulation in a luciferase assay. Haplotype association analysis with three SNPs (−12915C
>
T, 301G
>
C, and 546C
>
A) revealed that one haplotype (−12915T–301G–546C) was significantly represented in AgP patients (
p
=
0.000020). Thus, altered FPR1 function might confer increased risk to AgP.
We present azimuthal angular correlations between charged hadrons and energy deposited in calorimeter towers in central d+Au and minimum bias p+p collisions at sqrts_{NN}=200 GeV. The charged hadron ...is measured at midrapidity |η|<0.35, and the energy is measured at large rapidity (-3.7<η<-3.1, Au-going direction). An enhanced near-side angular correlation across |Δη|>2.75 is observed in d+Au collisions. Using the event plane method applied to the Au-going energy distribution, we extract the anisotropy strength v_{2} for inclusive charged hadrons at midrapidity up to p_{T}=4.5 GeV/c. We also present the measurement of v_{2} for identified π^{±} and (anti)protons in central d+Au collisions, and observe a mass-ordering pattern similar to that seen in heavy-ion collisions. These results are compared with viscous hydrodynamic calculations and measurements from p+Pb at sqrts_{NN}=5.02 TeV. The magnitude of the mass ordering in d+Au is found to be smaller than that in p+Pb collisions, which may indicate smaller radial flow in lower energy d+Au collisions.
A Front-End ASIC for a W + Si electromagnetic colorimeter has been developed in a 0.25 μm CMOS process. This calorimeter is proposed to measure prompt γ and π 0 in a wide energy range at forward ...rapidity region in high energy p + p and p + Pb collisions at LHC. The prototype ASIC consists of a current conveyor with 4 gain outputs in a first stage to achieve a large dynamic range from 10 fc to 200 pC. Simulation studies show that the linearity is less than 1% for the range of 10 4 . The prototype ASIC chip, which contains 6 input channels, was fabricated and some performance tests were conducted. In this report, design of the ASIC is described and performance obtained from simulations and the prototype chip are summarized.
A compact W+Si sampling electromagnetic calorimeter is under consideration as one of the upgrade plans for the LHC-ALICE experiment. Prototype of a W+Si pad based calorimeter was built and tested at ...CERN-PS in 2011. The overall performance of the protoype is reported in this article.
Charged-pion-interferometry measurements were made with respect to the second- and third-order event plane for Au+Au collisions at sqrts_{NN}=200 GeV. A strong azimuthal-angle dependence of the ...extracted Gaussian-source radii was observed with respect to both the second- and third-order event planes. The results for the second-order dependence indicate that the initial eccentricity is reduced during the medium evolution, which is consistent with previous results. In contrast, the results for the third-order dependence indicate that the initial triangular shape is significantly reduced and potentially reversed by the end of the medium evolution, and that the third-order oscillations are largely dominated by the dynamical effects from triangular flow.
A human T-cell clone (TA-NB-2) that could lyse both autologous and allogeneic hepatocytes from chronic hepatitis patients with type non-A, non-B virus (NANB) was established. This clone produced ...CD3+CD8+cytotoxic T lymphocytes and expressed an antigen specific for α and β subunits of T-cell receptor. The cytotoxic activity of the clone was abrogated by incubation with anti-CD3 monoclonal antibody. Anti-HLA monoclonal antibodies did not block the lysis of the target hepatocytes by TA-NB-2 cells. The cytotoxicity of TA-NB-2 clone against hepatocytes from patients with chronic NANB hepatitis was 39.8 ± 13.2% (mean ± SD; n = 17) (range, 14.2-60.5%), whereas that against hepatocytes from control patients with chronic type-B hepatitis, acute hepatitis B, acute hepatitis A, or alcoholic liver cirrhosis was 4.0 ± 7.7% (n = 12) (range, -10.8 to 14.0%). The results suggest that TA-NB-2 cells specifically recognize a hepatitis NANB-related antigen expressed on hepatitis NANB-infected hepatocytes by T-cell receptor and that the recognition is not restricted by the major histocompatibility complex antigens. The results also suggest that most, if not all, cases of chronic hepatitis due to NANB are caused by one agent; TA-NB-2 clone may be useful as a tool to identify this particular hepatitis-related antigen.
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