Minimum sets of in-vessel components were installed for initial operation of JT-60SA in order to product and control the plasma and to know the plasma basic information, including inboard first wall, ...upper divertor, protection limiter, glow electrodes and magnetic sensors. All of magnetic sensors were installed within the required accuracy with in-situ measurement with laser tracker. The inboard first wall and the upper divertor were installed for the limiter configuration at the plasma initiation and the divertor configuration, respectively. They have carbon tiles as the first wall, which must be installed with accuracy of ±1 mm in order to avoid the heat concentration. However, the vacuum-vessel wall had some deformation. Therefore, we measured in advance with laser tracker the position of the vacuum vessel where the bases of the inboard first wall and upper divertor would be welded. By using these position data and 3D CAD, we customized all bases. Owing to these procedures, we could install the first wall with required accuracy. Also, all other components were installed with required accuracy.
Chronic nonbacterial osteomyelitis is a rare bone disorder that can be found in the jaw. It is often associated with systemic conditions, including autoimmune deficiencies. However, little is known ...about how the genetic and immunologic background of patients influences the disease. Here, we focus on human leukocyte antigen (HLA), killer cell immunoglobulin-like receptors (KIRs), and their specific combinations that have been difficult to analyze owing to their high diversity. We employed a recently developed technology of simultaneous typing of HLA alleles and KIR haplotype and investigated alleles of the 35 HLA loci and KIR haplotypes composed of centromeric and telomeric motifs in 18 cases and 18 controls for discovery and 472 independent controls for validation. We identified an amino acid substitution of threonine at position 94 of HLA-C in combination with the telomeric KIR genotype of haplotype tA01/tB01 that had significantly higher frequency (>20%) in the case population than in both control populations. Multiple logistic regression analysis based on a dominant model with adjustments for age and sex revealed and validated its statistical significance and high predictive accuracy (C-statistic ≥0.85). Structure-based analysis revealed that the combination of the amino acid change in HLA-C and the telomeric genotype tA01/tB01 could be associated with lower stability of HLA-C. This is the first case-control study of a rare disease that employed the latest sequencing technology enabling simultaneous typing and investigated amino acid polymorphisms at HLA loci in combination with KIR haplotype.
Migration of
larvae in different mouse strains were compared, and infectivity of the persisting larvae in mice tissues were investigated. Five strains of mice, BALB/c, C57BL/6, AKR, B10.BR, and ICR ...were inoculated with 1,000
eggs/mouse, and necropsied at week 13 post inoculation (PI). The other uninfected ICR mice (secondary host) were inoculated with 43 larvae/ mouse recovered from mice at week 13 PI with eggs, and necropsied at day 21 PI. Larvae in organs or tissues were counted at necropsy. One AKR mouse showed torticollis and circling at day 56 PI. At necropsy at week 13 PI, larvae were recovered from all mice. A mean total larvae recovered were 124.1 (n=40). Majority of larvae were found in the carcass (mean 113.9) and some in the viscera (mean 9.9). Zero to 1 larva were found in the brain or eyes of some mice. There were no differences among the mouse strains in the number of larvae, except in the viscera; more larvae were seen in BALB/c or ICR than in B10.BR mice. No larvae were found in the secondary host mice. Present study demonstrated that
larvae migrate well in the carcass of any strains of mice, however, the tissue larvae did not infect the secondary host. Results of our present study suggest that
larvae is less aggressive for the nervous tissue migration than that of
larvae which is commonly known to migrate in central nervous system of mammals and birds.
The plasma rotation necessary for stabilization of resistive-wall modes (RWMs) is investigated by controlling the toroidal plasma rotation with external momentum input by injection of tangential ...neutral beams. The observed threshold is 0.3% of the Alfvén velocity and much smaller than the previous experimental results obtained with magnetic braking. This low critical rotation has a very weak beta dependence as the ideal wall limit is approached. These results indicate that for large plasmas such as in future fusion reactors with low rotation, the requirement of the additional feedback control system for stabilizing RWM is much reduced.
Disruption simulations with DINA code are performed for JT-60SA design. The simulation results have been applied for the design of many components, not only for the vacuum vessel and in-vessel ...components, but also for peripheral components. For instance, for the design of in-vessel coils, stabilizing plate and magnetic sensors, EM force induced by halo current and eddy current at disruption were calculated. For design of poloidal field (PF) coils, the power supply of PF coils and refrigerator system for super conducting coils, eddy current of PF coils and AC loss of superconducting coils were evaluated.
Isobaric single charge-exchange reactions, changing nuclear charges by one unit but leaving the mass partitions unaffected, have been for the first time investigated by peripheral collisions of 112Sn ...ions accelerated up to 1A GeV at the GSI facilities. The high-resolving power of the FRS spectrometer allows us to obtain (p,n)-type isobaric charge-exchange cross sections with an uncertainty of 3.5% and to separate quasi-elastic and inelastic components in the missing-energy spectra of the ejectiles. The inelastic component is associated to the excitation of the Δ(1232) isobar resonance and the emission of pions in s-wave both in the target and projectile nucleus, while the quasi-elastic contribution is associated to the nuclear spin-isospin response of nucleon-hole excitations. An apparent shift of the Δ-resonance peak of ∼63 MeV is observed when comparing the missing-energy spectra obtained from the measurements with proton and carbon targets. A detailed analysis, performed with a theoretical model for the reactions, indicates that this observation can be simply interpreted as a change in the relative magnitude between the contribution of the excitation of the resonance in the target and in the projectile.
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