The prediction of lane change intention of vehicles is an important part of the decision planning and control systems of intelligent vehicles. In the dynamic and complex traffic environment, the ...behaviors of traffic participants interact and influence each other. In lane change prediction, it is necessary to study the predicted vehicle and surrounding vehicles as an interactive correlation system. Otherwise, great errors are made in the motion prediction. Based on this, the motion state of the predicted vehicle, the position relationship between the predicted vehicle and lane, as well as the motion state of vehicles around the predicted vehicle are considered systematically in this paper, and the prediction of lane change intention of vehicles is studied. The influence of the three above-mentioned factors on the prediction of lane change intention is analyzed in this paper. On the basis of screening the prediction features of lane change intention, the lane change intention of vehicles is predicted by a feed-forward neural network. The data collected by the virtual driving experiment platform are divided into a training set, a verification set, and a test set. The neural network parameters of vehicles’ lane change intentions are identified by a training set, and the effect of prediction is tested by a verification set and a test set. The results show that the accuracy of the prediction model is high. The model is compared with the model of common features at the present stage and the model based on a Support Vector Machine, and the results show that the accuracy of the prediction model proposed in this paper was improved by 6.4% and 2.8%, respectively, compared with the two models. Finally, the virtual driving experiment platform was used to predict the lane change intention of the front vehicle and the vehicle in the left adjacent lane. The results show that, based on the same model and input features, the lane change intention of the front vehicle and the vehicle in the left adjacent lane can be predicted by the model at 2.8 s and 3.4 s before the lane change, and the model is a certain generality for the prediction of lane change intention of adjacent vehicles.
The in-wheel motor is installed in wheels, and road excitation acts on the in-wheel motor directly through a wheel, which affects the flow field characteristics of the motor’s liquid cooling system, ...and affects the thermal field characteristics of the in-wheel motor. Aiming at this problem, the in-wheel motor drive system is taken as the research object in this paper. Firstly, the heat flow coupling analysis model of the in-wheel motor drive system is established by using the heat flow coupling theory. Then the vibration response of in-wheel motor stator and shell under different road excitation obtained from the previous study is taken as the load. Finally, thermal field characteristics of the water-cooled the in-wheel motor under different working conditions are studied, and the influence law of different speed and road grades on the thermal field characteristics is obtained. The results show that under the road excitation, the maximum temperature of each component of the in-wheel motor decreases due to the vibration effect of road excitation on the flow field of the cooling system, and the decrease of the stator and winding is the most obvious. Additionally, the higher the speed, the greater the road roughness coefficient, the greater the temperature drop of each component of the in-wheel motor. However, the thermal field distribution of local parts of the motor is relatively uneven under road excitation, which leads to greater thermal stress of the local parts and increases the risk of motor damage.
Background and Aim
Considering the limitation of varying acid suppression of proton pump inhibitors, this study was aimed to assess the efficacy, safety, and dose–effect relationship of keverprazan, ...a novel potassium‐competitive acid blocker, in the treatment of duodenal ulcer (DU) compared with lansoprazole.
Methods
A randomized, double‐blind, double‐dummy, multicenter, low‐dose, high‐dose, and positive‐drug parallel‐controlled study was conducted to verify the non‐inferiority of keverprazan (20 or 30 mg) to lansoprazole of 30 mg once daily for 4 to 6 weeks and dose–effect relationship of keverprazan in the treatment of patients with active DU confirmed by endoscopy.
Results
Of the 180 subjects randomized, including 55 cases in the keverprazan_20 mg group, 61 cases in the keverprazan_30 mg group, and 64 cases in the lansoprazole_30 mg group, 168 subjects (93.33%) completed the study. The proportions of healed DU subjects in the keverprazan_20 mg, keverprazan_30 mg, and lansoprazole_30 mg groups were respectively 87.27%, 90.16%, and 79.69% at week 4 (P = 0.4595) and were respectively 96.36%, 98.36%, and 92.19% at week 6 (P = 0.2577). The incidence of adverse events in the keverprazan_20 mg group was lower than that in the lansoprazole_30 mg (P = 0.0285) and keverprazan_30 mg groups (P = 0.0398).
Conclusions
Keverprazan was effective and non‐inferior to lansoprazole in healing DU. Based on the comparable efficacy and safety data, keverprazan of 20 mg once daily is recommended for the follow‐up study of acid‐related disorders. (Trial registration number: ChiCTR2100043455.)
The driving conditions of vehicles, such as rapid acceleration, lasting downhill and so on, which demand for drive power, are rapidly increasing. For an electric vehicle driven by in-wheel motor ...(IWM), the IWM needs to provide greater power to maintain the normal operation of the vehicle. At present, the pursuit of high power density for IWM reduces the volume of motor under the same power. But the loss density is increased correspondingly, which will lead to overheating of IWM. In this paper, a 15-kW IWM drive system is taken as the research object. Based on the establishment of the temperature analysis model, instantaneous thermal characteristics of the IWM drive system are analyzed under the long climbing condition with low-speed and rapid acceleration driving cycles. The results show that the temperature of the stator winding and stator core is relatively high under the two driving cycles. The temperature of the stator winding is always in the highest level, and the maximum all appear on the end winding. The highest temperature of the end winding can reach 229.49 °C under the rapid acceleration driving cycles, which significantly exceeds the limitation for the insulation (155 °C) and will seriously affect the normal operation of the IWM and the vehicle. Therefore, in the follow-up design of cooling system, spray cooling with good local cooling effect can be adopted to focus on the cooling for the end winding. This paper can provide theory for the design of the feasibility thermal cooling solution.
In this paper, a 15 KW in-wheel motor (IWM) is taken as the research object, and the coupling factors among the electromagnetic field, temperature field and flow field are analyzed, and the strong ...and weak coupling factors between the three fields are clarified, and by identifying the strong and weak coupling factors between the three fields, a three-field coupling analysis model for IWM with appropriate complexity is established, and the validity of the model is verified. In a certain driving condition, the electromagnetic field, temperature field and flow field characteristics of IWM are analyzed with the multi-field coupling model. The result shows that, after the IWM runs 8440 s under driving conditions, in this paper, the IWM electromagnetic torque of the rated working condition is 134.2 Nm, and IWM the electromagnetic torque of the peak working condition is 451.36 Nm, and the power requirement of the motor can be guaranteed. The highest temperature of the IWM is 150 °C, which does not exceed the insulation grade requirements of the motor (155 °C), the highest temperature of the permanent magnet (PM) is 65.6 °C, and it does not exceed the highest operating temperature of the PM, and ensures the accurate calculation of components loss and the temperature of the motor. It can be found, through research, that the electromagnetic torque difference between unidirectional coupling and bidirectional coupling is 3.2%, the maximum temperature difference is 7.98% in the three-field coupling analysis of IWM under rated working conditions. Therefore, it is necessary to consider the influence of coupling factors on the properties of motor materials when analyzing the electromagnetic field, temperature field and flow field of IWM; it also provides some reference value for the simulation analysis of IWM in the future.
For the in-wheel motor (IWM)-driven electric vehicle, the drive motor is directly integrated in the wheel. The magnet gap deformation of the motor can be generated due to road surface roughness (RSR) ...excitation, uneven load, and other reasons. The magnet gap deformation will lead to unbalanced magnetic force, which is a critical vibration source to the vehicle dynamics. Focusing on this problem, an IWM-driven electric vehicle without a speed reducer is considered as the research subject, and an 11-degree-of-freedom dynamics model is developed and verified to study the magnetic force influence on vehicle vertical and lateral coupling dynamics. The effect of magnetic force on the vehicle dynamics is analyzed under two operation conditions first. The results show that the magnetic force makes all dynamic response variables deteriorate in different degrees, regardless of the operation conditions, which indicates that the magnetic force has some negative influence on both the vertical and lateral vehicle dynamics. The results also show that even if the hub bearing stiffness is 5 MN/m, the maximum magnet gap deformation of the IWMs can still reach a big value. Therefore, the hub bearing stiffness should be designed to be stiff enough to conquer the magnet gap deformation under permitting conditions. In addition, extended study is performed with different motor speeds to further investigate the vehicle coupling dynamics. The results show that all the root-mean square (RMS) values of the evaluation indexes increase with the increase in motor speed. This result contributes to both RSR and magnetic force, since the motor speed is not only related to road excitation but also concerns magnetic force. For electric vehicles driven by IWMs, magnetic force must be considered as one of the important factors in the system design. This study can provide some theoretical basis for the design, optimization, and coordinated control of the IWM-driven electric vehicles.
Nonenzymic glycation, also known as the Maillard reaction, is a complex series of reactions between reducing sugars and amino compounds. Previous studies have demonstrated that reactive dicarbonyl ...compounds (e.g., methylglyoxal MG and glyoxal GO), formed as intermediate products of the Maillard reaction, irreversibly and progressively modify proteins over time and yield advanced glycation end products (AGEs), which are thought to contribute to the development of diabetes mellitus and its complications. Several studies have shown that higher levels of MG are present in diabetic patients' plasma than in healthy people's plasma. Thus, decreasing the levels of MG and GO will be an effective approach to reduce the formation of AGEs and the development of diabetic complications. Here, we briefly describe our effort in searching for non‐ or less‐toxic trapping agents of reactive dicarbonyl species from dietary sources. In addition, we have discovered that commercial beverages contain extremely high levels of MG. The potential hazardous effects of dietary MG on humans remain to be explored.
Objective： To systematically evaluate the effectiveness and safety of Sodium Tanshinone ⅡA Sulfonate Injection（STS） as one adjuvant therapy for treating unstable angina pectoris（UAP）. Methods： ...Randomized controlled trials（RCTs） of UAP treated by STS were searched in the China National Knowledge Infrastructure Database（CNKI）, VIP Database for Chinese Technical Periodicals（VIP）, Wanfang Database, the Chinese Biomedical Literature Database（CBM）, Web of Science, the Cochrane Library, Embase, and Pub Med, which from inception to January, 2016. The Cochrane Risk Assessment Tool was used to evaluate the methodological quality of the RCTs. The Review Manager 5.3 software was used to conduct the metaanalysis. Results： The results showed that 17 RCTs involving 1,372 patients were included. The meta-analysis indicated that the combined use of STS and Western medicine（WM） in the treatment of UAP can obviously improve the total effective rate risk ratio（RR）=1.31, 95% confidence interval（CI）（1.24,1.39）, P〈0.0001, and the total effective rate of electrocardiogram RR=1.43, 95% CI（1.30,1.56）, P〈0.0001, decrease the level of CRP mean difference（MD）=–3.06, 95%CI（–3.85, –2.27）, P〈0.00001, fibrinogen MD=–1.03, 95% CI（–1.16, –0.89）, P〈0.00001, and whole blood high shear viscosity MD=–0.70, 95% CI（–0.92, –0.49）, P〈0.00001. Additionally, the occurrence of adverse drug reaction of the experimental group was significantly higher than that of the control group RR=3.57, 95% CI（1.28, 9.94）, P〈0.05. Conclusions： Compared with WM, the combined use of STS was more effective.
Bacteria release flagellin that elicits innate responses via Toll-like receptor 5 (TLR5). Here, we investigated the fate of apically administrated full length flagellin from virulent and avirulent ...bacteria, along with truncated recombinant flagellin proteins in intestinal epithelial cells and cellular responses. Flagellin was internalized by intestinal epithelial cell (IEC) monolayers of IEC-18. Additionally, apically applied flagellin was internalized by polarized human Caco-2BBe and T-84 cells in a TLR5 dependent mechanism. More, flagellin exposure did not affect the integrity of intestinal monolayers. With immunofluorescent staining, internalized flagellin was detected in both early endosomes as well as lysosomes. We found that apical exposure of polarized Caco-2BBe and T-84 to flagellin from purified Salmonella, Escherichia coli O83:H1 (isolate from Crohn's lesion) or avirulent E. coli K12 induced comparable levels of basolateral IL-8 secretion. A recombinant protein representing the conserved amino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1) induced IL-8 secretion from IEC similar to levels elicited by full-length flagellins. However, a recombinant flagellin protein containing only the D3 hypervariable region elicited no IL-8 secretion in both cell lines compared to un-stimulated controls. Silencing or blocking TLR5 in Caco-2BBe cells resulted in a lack of flagellin internalization and decreased IL-8 secretion. Furthermore, apical exposure to flagellin stimulated transepithelial migration of neutrophils and dendritic cells. The novel findings in this study show that luminal-applied flagellin is internalized by normal IEC via TLR5 and co-localizes to endosomal and lysosomal compartments where it is likely degraded as flagellin was not detected on the basolateral side of IEC cultures.
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