In cancer treatment organ and tissue deformation betweenradiotherapy sessions represent a significant challenge to op-timal planning and delivery of radiation doses. Recent de-velopments in image ...guided radiotherapy has caused a soundrequest for more advanced approaches for image registrationto handle these deformations. Viscous-fluid registration isone such deformable registration method. A drawback withthis method has been that it has required computation timesthat were too long to make the approach clinically appli-cable. With recent advances in programmability of graph-ics hardware, complex user defined calculations can now beperformed on consumer graphics cards (GPUs). This pa-per demonstrates that the GPU can be used to drasticallyreduce the time needed to register two medical 3D imagesusing the viscous-fluid registration method. This facilitatesan increased incorporation of image registration in radio-therapy treatment of cancer patients, potentially leading tomore efficient treatment with less severe side effects.
In cancer treatment organ and tissue deformation between
radiotherapy sessions represent a significant challenge to op-
timal planning and delivery of radiation doses. Recent de-
velopments in image ...guided radiotherapy has caused a sound
request for more advanced approaches for image registration
to handle these deformations. Viscous-fluid registration is
one such deformable registration method. A drawback with
this method has been that it has required computation times
that were too long to make the approach clinically appli-
cable. With recent advances in programmability of graph-
ics hardware, complex user defined calculations can now be
performed on consumer graphics cards (GPUs). This pa-
per demonstrates that the GPU can be used to drastically
reduce the time needed to register two medical 3D images
using the viscous-fluid registration method. This facilitates
an increased incorporation of image registration in radio-
therapy treatment of cancer patients, potentially leading to
more efficient treatment with less severe side effects.
The purpose of this study was to describe our initial "real-world" experience with vascular b-radiation for in-stent restenosis using a simple angioplasty approach without stent implantation.
...Thirty-five consecutive patients with in-stent restenosis were treated with balloon angioplasty (n = 28), cutting balloon angioplasty (n = 3), or angioplasty plus stent implantation (only in case of significant dissection: n = 4), followed by catheter-based beta-radiation. Angiographic follow-up was performed after 6 to 10 months.
One patient experienced a left main stem occlusion immediately after beta-radiation, which necessitated an acute coronary bypass operation. No other complications related to the radiation procedure were observed. In-stent restenosis recurred in 6 of the 34 patients (18%).
Our results indicate that catheter-based radiation can be safely introduced at centres without previous experience with this treatment modality. Furthermore, the in-stent restenosis recurrence rates after catheter-based radiation which have been obtained in randomised trials can be reproduced in consecutive patients.
Magnetic resonance imaging (MRI)-guided brachytherapy for locally advanced cervical cancer was introduced at Aarhus University Hospital in December 2005. Until then two-dimensional (2D) X-ray based ...planning had been performed with prescription of dose to point A. After a short learning period of 2 months, we moved to full prospective MRI-guided dose planning and optimization for every brachytherapy fraction. Two fractions of pulsed dose rate (PDR) brachytherapy are given, and a planning MRI is obtained one week prior first brachytherapy in order to plan the application. An MRI compatible tandem-ring applicator is used. When parametrial extension would lead to insufficient coverage by an intracavitary application, a combined intracavitary-interstitial applicator is used with blunt-ended titanium needles.
Simulation of cervical cancer response to radiotherapy Kyroudis, Christos A.; Dionysiou, Dimitra D.; Kolokotroni, Eleni A. ...
Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation - The CHIC Project Workshop (IARWISOCI),
11/2014
Conference Proceeding
The goal of this article is to present basic scientific principles and core algorithms of the simulation module of the CERvical cancer ONCOsimulator (CERONCO) developed within the context of the ...DrTherapat project (FP7-ICT-600852). CERONCO simulates the response of cervical tumours to radiotherapy treatment (external beam radiotherapy followed by brachytherapy) with concomitant weekly cisplatin, in the patient-individualized context. Results from a preliminary clinical adaptation study based on the MR imaging data of a clinical case are presented as well.
The integration of 3D imaging for gynecological brachytherapy treatment planning allows the use of dose and volume parameters to describe the dose distribution related to target volumes and normal ...tissue. The dose and volume specifications introduced by the GEC ESTRO serve as recommendations for recording and reporting, and can also be used for prospective treatment planning. However, these dose volume histogram parameters do not fully describe the spatial dose distribution. By increasing the target conformity and dose shaping, accuracy in the 3D reconstruction of applicator geometry and its relation to the anatomy is paramount. This form of brachytherapy can be performed as real image-guided radiotherapy, with adaptive treatment planning for each application or fraction. Uncertainties and variations must be studied and taken into account to arrive at high-quality treatments with increased target dose and lower dose to the organs at risks.
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