The paper focuses on ceramic vessels unearthed from Copper Age necropolises located in the area of the modern city of Rome and commonly attributed to the Rinaldone culture. The peculiar vessels' ...shapes, mainly associated with the consumption of beverages, their accuracy of manufacture and the very low impact of these ceramic morphologies in the coeval household assemblages lead to the study of such an apparently selected production through a multidisciplinary research. Petrographic analysis, X‐ray fluorescence (XRF) and X‐ray diffraction (XRD) integrated with the analysis of manufacturing traces and X‐ray investigation suggest the transmission of technological choices, which remained unchanged over almost two millennia.
This article shows the first pigment identification of the Campana reliefs, Roman architectural earthenware plaques. The Campana reliefs polychromy were investigated by applying a multidisciplinary ...approach involving non-invasive and micro-destructive techniques to some fragments with traces of colour found on the north-eastern slopes of the Palatine Hill in Rome. X-ray fluorescence analysis and reflectance measurements provided preliminary identification of pigments, which was subsequently confirmed by X-ray diffraction and elemental mapping by scanning electron microscopy-energy dispersive spectrometry carried out on micro-samples and cross sections, respectively. Yellow ochre, red ochre, lead white, calcium-based white pigment, Egyptian blue and minium were identified. In addition, PIL (Photo Induced Luminescence) imaging was performed, identifying the macro-distribution of Egyptian blue, even on plaques without visible traces of colour.
Although didelphid marsupials are considered to have a conservative body shape, they show a considerable amount of size variation. They also have different diets (from frugivore to animalivore), but ...none of the species are specialized. Didelphid marsupials also have a certain degree of specialization in vertical habitat use, from ground-dwellers to canopy-dwellers. Several authors have shown in other mammals that diet, activity patterns, locomotion, and habitat use influence skull shape in different groups of mammals, but also phylogenetic legacy plays a major role in skull evolution. Up till now, there are no published studies that investigate the form-function relationship in didelphid skulls; so the aim of this study is to analyze to what extent diet and vertical habitat use influence skull shape and override the influence of size and phylogeny. We used 2D geometric morphometry data from the skull and by analyzing the phylomorphospace, GLS, and PGLS we studied the effect of diet, vertical habitat use, allometry, and phylogenetic legacy on shape. Our results show that there are almost no shape differences between species of different diets and use of the vertical habitat, while allometry shows a strong correlation with shape, and also there is an evident effect of phylogenetic history. As didelphimorphians are not highly specialized, it is possible they developed a more generalized skull shape, flexible enough to adapt to different pressures. Moreover, as they have a highly integrated skull with few modules, it is expected that they respond to selection pressures by changing their size.
The FACE-BD cohort is an observational cohort of individuals with bipolar disorders (BD) who benefited from a systematic evaluation with evidence-based treatment recommendations and who were ...followed-up every year for 3 years in France. The objectives were to describe the lifetime course of BD, associated psychiatric and somatic comorbidities, and cognition profile. This cohort aims to identify clinical/biological signatures of outcomes, trajectories of functioning and transition between clinical stages. This article summarizes 10 years of findings of the FACE-BD cohort.
We included 4422 individuals, all having a baseline assessment, among which 61.2% had at least one follow-up visit at either one, two or three years. A subsample of 1200 individuals had at least one biological sample (serum, plasma, DNA). Assessments include family history of psychiatric disorders, psychiatric diagnosis, current mood symptoms, functioning, hospitalizations, suicidal attempts, physical health, routine blood tests, treatment history, psychological dimensions, medico-economic data and a cognitive assessment. Studies from this cohort illustrate that individuals with BD display multiple coexistent psychiatric associated conditions including sleep disturbances, anxiety disorders, substance use disorders and suicide attempts as well as a high prevalence of metabolic syndrome. During follow-up, we observed a 55% reduction of the number of days of hospitalization and a significant improvement in functioning.
The FACE-BD cohort provides a strong research infrastructure for clinical research in BD and has a unique position among international cohorts because of its comprehensive clinical assessment and sustainable funding from the French Ministry of Health.
•The FACE-BD cohort is a french longitudinal, multicentric, observational cohort of individuals with bipolar disorders•The FACE-BD cohort provides a strong research infrastructure for research on BD•4422 participants with bipolar disorders have been extensively assessed and followed up three years
L’essere umano è immerso nel mondo, nella realtà umana costantemente in relazione e il suo sguardo è inevitabilmente sugli oggetti, sui fatti, sull’Altro. In un’ottica fenomenologica- esistenziale ...l’Altro è colui che mi costituisce e che io costituisco attraverso lo sguardo. È ciò che emerge nella mia ricerca sull’accoglienza domestica mediante la quale, con la raccolta di 74 storie di vita, analizzo il fenomeno della mobilità e il tentativo di questi esseri umani di inserirsi in un nuovo contesto.
Introduction
Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar ...disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS.
Methods
Participants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE‐BD) cohort and followed‐up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow‐up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow‐up. We applied inverse probability‐of‐censoring weighting method to minimize selection bias due to loss during follow‐up.
Results
Among individuals without MetS at baseline (n = 1521), 19.3% developed MetS during follow‐up. Multivariable analyses showed that incident MetS during follow‐up was significantly associated with male sex (OR = 2.2, 95% CI = 1.7–3.0, p < 0.0001), older age (OR = 2.14, 95% CI = 1.40–3.25, p = 0.0004), presence of a mood recurrence during follow‐up (OR = 1.91, 95% CI = 1.22–3.00, p = 0.0049), prolonged exposure to second‐generation antipsychotics (OR = 1.56, 95% CI = 0.99, 2.45, p = 0.0534), smoking status at baseline (OR = 1.30, 95% CI = 1.00–1.68), lifetime alcohol use disorders (OR = 1.33, 95% CI = 0.98–1.79), and baseline sleep disturbances (OR = 1.04, 95% CI = 1.00–1.08), independently of the associations observed for baseline MetS components.
Conclusion
We observed a high incidence of MetS during a 3 years follow‐up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS.
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