Summary
Background
(Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing ...clinical presentations.
Objectives
To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clinical data.
Methods
A retrospective review of results from patch tests performed between July 2002 and September 2015, in one tertiary Cutaneous Allergy Unit, was performed
Results
A series of 28 (meth)acrylates was applied to 475 patients. Results were positive in 52 cases, with occupational sources being identified in 24. Industrial exposures and acrylic nails were responsible for 13 and 10 cases, respectively, with wound dressings being implicated in 7. We found that four individual (meth)acrylates (2‐hydroxyethyl acrylate, 2‐hydroxypropyl methacrylate, bisphenol A glycerolate dimethacrylate, and ethyl acrylate), if used as a screening tool, could have identified 47 (90.4%) of our positive cases.
Conclusions
Our 13‐year experience indicates a changing landscape of (meth)acrylate contact allergy and allergic contact disease, with an observed shift in exposures away from manufacturing and towards acrylic nail sources. Wound dressings are highlighted as emerging sources of sensitization. Larger studies are required to establish the sensitivity and specificity of the four (meth)acrylates proposed for potential screening.
Who is LISA? Thompson, Donna
EPJ Web of Conferences,
01/2018, Letnik:
186
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
The field of library science is always changing. Even professional library organizationshave conducted studies about changing the name of the profession. All of the attendees of the LISA meeting are ...involved in Library and Information Sciences in Astronomy and we represent a number of different organizations and professions. In crafting a white paper about the profession, an ethnographic study of the field was proposed with the research reported on at the LISA meeting. The research methods include an online survey and in person interviews with various members of the community. We hope to identify trends, differences and a road map for the future.
The urology nurse has not only instructed patients in managing urinary retention, held the hand of a newly incontinent man after radical prostatectomy, and performed urodynamic evaluations or managed ...patients with long-term indwelling catheters, but has also counseled patients on bladder retraining and strategies to prevent urine leakage, made recommendations for containment products, assisted with skin protection, and provided education on how to prevent constipation. Today, the role of the urology nurse as a continence nurse has grown to encompass pelvic floor rehabilitation with biofeedback, percutaneous tibial nerve stimulation (PTNS), programming and monitoring sacral nerve stimulation, follow-up care of patients with Botox® injections, and surgical placement of artificial sphincters, as well as continuing to provide what has been defined by the American Urological Association (AUA) (Gormley et al., 2012) as first-line management strategies for non-neurogenic over active bladder (OAB). Ongoing SUNA conferences; online continuing education offerings; publications, such as SUNA's Core Curriculum for Urologic Nursing and SUNA's official journal Urologic Nursing; and the newly launched online community Ur°Connect, are also in line with the recommendation of Wagg and colleagues (2014) to "train existing healthcare professionals, such as primary care-based nurse practitioners, community nurses, physician's assistants...to provide evidence-based continence care" (p. 4).
Purpose
The 21-gene recurrence score (RS) assay predicts the recurrence risk and magnitude of chemotherapy benefit in patients with invasive breast cancer (BC). This study examined low-grade tumors ...yielding a high-risk RS and their outcomes.Kindly check the edit made in the article titleOk
Methods
We compared patients with grade 1 BC and a high-risk RS to those with low-risk RS. Histologic sections were reviewed and features reported to elevate the RS were noted, mainly biopsy cavity and reactive stromal changes (BXC).
Results
A total of 54 patients had high-risk RS (median RS of 28, range 26–36). On review, BXC were seen in all cases. Thirty BCs in this group also had low to negative PR. Treatment regimens included: chemoendocrine therapy (63%), endocrine therapy alone (31%) and no adjuvant therapy (6%). There were no additional breast cancer events over a median follow-up of 54.0 months (range 6.2 to 145.3). A total of 108 patients had low-risk RS (median RS of 7, range 0–9). BXC were seen in 47% of cases and none were PR negative. One patient had a recurrence at 64.8 months while the rest had no additional events over a median of 68.1 months (2.4 to 100).
Conclusion
We provide further evidence that reactive stromal changes and/or low-PR scores enhance the elevation of the RS. A high-RS result in low grade, PR-positive BC may not reflect actual risk and any suspected discrepancies should be discussed with the management teams. Multigene testing results should be interpreted after correlation with pathologic findings to optimize patient care.
Data from 72 infants, tested using a serial paired‐comparison paradigm, were analyzed to better understand infant novelty preferences. Infants between the ages of 15 and 26 weeks were tested in three ...studies with familiar stimuli displayed adjacent to novel stimuli on each trial. Differences in look duration, look number, and gaze shifts directed at novel versus familiar stimuli were assessed to measure their contributions to group and individual novelty preferences. Infants produced longer looks for novel stimuli in all three studies, and stimulus differences in look duration accounted for more than 50% of the variability in individual novelty preferences. Infants that produced more looks to novel rather than familiar stimuli did not produce overall novelty preferences unless they also looked longer at novel stimuli. Gaze shift patterns did not predict individual novelty preferences, and novel stimuli did not determine where infants looked. The infants’ visual exploration was constrained by memories for the direction of the previous look as well as by the attention‐holding features of novel stimuli.
Technology-assisted self-management programs are increasingly recommended to patients with long-term conditions such as diabetes. However, there are a number of personal and external factors that ...affect patients' abilities to engage with and effectively utilize such programs. A randomized controlled trial of a multi-modal online program for diabetes self-management (BetaMe/Melon) was conducted in a primary care setting, and a process evaluation was completed at the end of the study period.
This process evaluation aimed to examine the utilization patterns of BetaMe/Melon, identify which components participants found most (and least) useful, and identify areas of future improvement.
Process evaluation data were collected for intervention arm participants from 3 sources: (1) the mobile/web platform (to identify key usage patterns over the 16-week core program), (2) an online questionnaire completed during the final study assessment, and (3) interviews conducted with a subset of participants following the study period. Participants were classified as "actively engaged" if any usage data was recorded for the participant (in any week), and patterns were reported by age, gender, ethnicity, and diabetes/prediabetes status. The online questionnaire asked participants about the usefulness of the program and whether they would recommend BetaMe/Melon to others according to a 5-point Likert Scale. Of 23 invited participants, 18 participated in a digitally recorded, semistructured telephone interview. Interview data were thematically analyzed.
Out of the 215 participants, 198 (92%) received an initial health coaching session, and 160 (74%) were actively engaged with the program at some point during the 16-week core program. Engagement varied by demographic, with women, younger participants, and ethnic majority populations having higher rates of engagement. Usage steadily declined from 50% at Week 0 to 23% at Week 15. Participants ranked component usefulness as education resources (63.7%), health coaches (59.2%), goal tracking (48.8%), and online peer support (42.1%). Although 53% agreed that the program was easy to use, 64% would recommend the program to others. Interview participants found BetaMe/Melon useful overall, with most identifying beneficial outcomes such as increased knowledge, behavioral changes, and weight loss. Barriers to engagement were program functionality, internet connectivity, incomplete delivery of all program components, and participant motivation. Participants suggested a range of improvements to the BetaMe/Melon program.
The program was generally well received by participants; active engagement was initially high, although it declined steadily. Maintaining participant engagement over time, individualizing programs, and addressing technical barriers are important to maximize potential health benefits from online diabetes self-management programs.
Australian New Zealand Clinical Trial Registry ACTRN12617000549325; https://tinyurl.com/y622b27q.
This study examined how look dynamics contribute to infants’ emerging novelty preferences. Time‐series analyses were used to study the temporal nature of looking displayed by 3‐ to 5‐month‐old ...infants during a serial paired‐comparison task. Evidence was found only for short‐term stability: Novelty preferences and side biases were not stable from one visit to the next, but looking was consistent from one moment to the next producing stability within trials and temporarily across trials leading to the formation of behavioral runs. Persistence in looking left or right across multiple trials did not change from one visit to the next, but persistence in looking at familiar stimuli declined with age. By Visit 3, familiarity runs occurred less often than did novelty runs. Frequent but highly variable runs, including surprisingly late familiarity preferences, suggest that overall side biases and novelty preferences found during visual preference tasks are emergent phenomena affected by moment‐to‐moment changes in looking.
Modifying fluid intake to decrease overactive bladder (OAB) symptoms, urgency, frequency, and urge urinary incontinence is advocated by health care professionals.
This Evidence Based Report Card ...reviews whether increasing or decreasing the daily intake of water and/or fluids by adults decreases their OAB symptoms.
Three reviewers systematically reviewed the literature for studies that evaluated the association or effect of fluid intake on OAB urinary symptoms in adult men and women. A professional librarian performed the literature search, which yielded 260 articles. Following title and abstract reviews, 48 articles were identified for full-text review, and of these, 10 articles met the criteria for inclusion in this review.
Results of studies measuring the effect of fluid intake on the severity of OAB symptoms support that reducing fluid intake is beneficial in reducing OAB symptoms of urge UI, urgency, and frequency. There is evidence that increasing fluid by 25% to 50% could increase daytime frequency; however, studies did not show a significant effect on urgency. Increasing fluid intake is associated with worsening of OAB symptoms in observational studies and shows no difference in symptoms compared to controls in interventional studies.
WOC nurses should recommend decreased fluid intake for managing OAB symptoms, while ensuring adequate hydration for other health needs (Strength of Recommendations for Treatment statement level 1).
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