OBJECTIVE:Exposure to airborne particulate matter (PM) is estimated to cause millions of premature deaths annually. This work conveys known routes of exposure to PM and resultant health effects.
...METHODS:A review of available literature.
RESULTS:Estimates for daily PM exposure are provided. Known mechanisms by which insoluble particles are transported and removed from the body are discussed. Biological effects of PM, including immune response, cytotoxicity, and mutagenicity, are reported. Epidemiological studies that outline the systemic health effects of PM are presented.
CONCLUSION:While the integrated, per capita, exposure of PM for a large fraction of the first-world may be less than 1 mg per day, links between several syndromes, including attention deficit hyperactivity disorder (ADHD), autism, loss of cognitive function, anxiety, asthma, chronic obstructive pulmonary disease (COPD), hypertension, stroke, and PM exposure have been suggested. This article reviews and summarizes such links reported in the literature.
We present imrphenomxphm, a phenomenological frequency-domain model for the gravitational-wave signal emitted by quasicircular precessing binary black holes, which incorporates multipoles beyond the ...dominant quadrupole in the precessing frame. The model is a precessing extension of imrphenomxhm, C. García-Quirós et al., Phys. Rev. D 102, 064002 (2020) based on approximate maps between aligned-spin waveform modes in the coprecessing frame and precessing waveform modes in the inertial frame, which is commonly referred to as "twisting up" the nonprecessing waveforms. imrphenomxphm includes imrphenomxp as a special case, the restriction to the dominant quadrupole contribution in the coprecessing frame. We implement two alternative mappings, one based on a single-spin post-Newtonian approximation, as used in imrphenompv2 M. Hannam et al., Phys. Rev. Lett. 113, 151101 (2014)., and one based on the double-spin multiple scale analysis approach of K. Chatziioannou et al., Phys. Rev. D 95, 104004 (2017).. We include a detailed discussion of conventions used in the description of precessing binaries and of all choices made in constructing the model. The computational cost of imrphenomxphm is further reduced by extending the interpolation technique of C. García-Quirós et al., Classical Quant. Grav. 38, 015006 (2021). to the Euler angles. The accuracy, speed, robustness, and modularity of the imrphenomx family will make these models productive tools for gravitational wave astronomy in the current era of greatly increased number and diversity of detected events.
A 96-well microplate reader for absorption spectroscopy was designed, constructed, and tested at a total cost of ca. 500 USD. The reduced cost of the device represents the major technical ...contribution of this manuscript, as costs were reduced 7 fold from previous reports. The device was able to achieve 3σ limits of detection of ca. 0.01 absorbance units (AU) over a 60 second measurement for the mid-visible wavelength range. Component parts are either commercially available, or 3D printed from plans. Analysis wavelength can be altered throughout the visible region through use of various photographic or theatrical filters. This feature allows the well plate reader to be used for typical laboratory assays such as cell population estimation by optical density (OD) at 600 nm, or enzyme-linked immunosorbent assays (ELISA) at 450 nm. This manuscript reports on the motivation and process of constructing the device, lists required parts, presents data demonstrating device function, and provides the community of scholars with plans to reproduce the work. The device can be reproduced in laboratories lacking sufficient resources to purchase commercially available options and this outcome contributes towards empowerment of individuals and equity of scientific enquiry.
Accurate gravitational-wave (GW) signal models exist for black hole binary (BBH) and neutron-star binary (BNS) systems, which are consistent with all of the published GW observations to date. ...Detections of a third class of compact-binary systems, neutron-star black hole (NSBH) binaries, have not yet been confirmed, but are eagerly awaited in the near future. For NSBH systems, GW models do not exist across the viable parameter space of signals. In this work we present the frequency-domain phenomenological model, phenomnsbh, for GWs produced by NSBH systems with mass ratios from equal-mass up to 15, spin on the black hole (BH) up to a dimensionless spin of | χ | = 0.5 , and tidal deformabilities ranging from 0 (the BBH limit) to 5000. We extend previous work on a phenomenological amplitude model for NSBH systems to produce an amplitude model that is parametrized by a single tidal deformability parameter. This amplitude model is combined with an analytic phase model describing tidal corrections. The resulting approximant is compared to publicly available NSBH numerical-relativity simulations and hybrid waveforms constructed from numerical-relativity simulations and tidal inspiral approximants. For most signals observed by second-generation ground-based detectors, it will be difficult to use the GW signal alone to distinguish single NSBH systems from either BNSs or BBHs, and therefore to unambiguously identify an NSBH system.
Irradiation of aqueous (pHaa=aa5) mixtures containing hydrogen peroxide (1aamM) and phenolic compounds (10aamM) were found to produce visible light absorbing solutions over the course of several ...hours. The kinetics and products of these reactions were studied by UV-VIS absorbance, electrospray mass spectrometry, FTIR, fluorescence, and NMR and compared to humic-like substances commonly found in atmospheric particulate matter. It was determined the reactions leading to formation of color are quite general to this compound class, and the reactions proceeded more rapidly with hydroxyl or methoxy substitution ortho to the phenolic OH. However, para substitution generally slowed formation of colored compounds compared to the unsubstituted form. Mass spectrometry confirms compounds of several hundred Da formed in the reaction mixtures. The IR spectra of the reaction products bear similarity to that observed for authentic aerosol humic-like substances. The results indicate radical coupling of phenols and methoxylated phenols in tropospheric waters may contribute to humic-like particulate matter.
Matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry (MS) has become a valuable laboratory tool for rapid diagnostics, research, and exploration in veterinary ...medicine. While instrument acquisition costs are high for the technology, cost per sample is very low, the method requires minimal sample preparation, and analysis is easily conducted by end-users requiring minimal training. Matrix-assisted laser desorption ionization-time-of-flight MS has found widespread application for the rapid identification of microorganisms, diagnosis of dermatophytes and parasites, protein/lipid profiling, molecular diagnostics, and the technique demonstrates significant promise for 2D chemical mapping of tissue sections collected postmortem. In this review, an overview of the MALDI-TOF technique will be reported and manuscripts outlining current uses of the technology for veterinary science since 2019 will be summarized. The article concludes by discussing gaps in knowledge and areas of future growth.
An inexpensive and portable device for monitoring personal ozone exposure is described and its performance characterized. The device is built from commercially available components, exhibits time ...resolution of approx. 60s, and highest analytical sensitivity under 100ppbv ozone. The sensor has been employed to provide insights into ozone exposure for 8 volunteers living in Lubbock, Texas during the winter months of 2015. Consistent with previous literature, the results indicate the volunteers were exposed to highest levels of ozone when outdoors during daylight hours. Exposure to ozone indoors was typically only a fraction (0.3–0.7) of the dose observed during times spent outdoors. The sensing system described requires minimal technical skills to assemble and use at a cost of approximately $150 USD per unit (see Table 1). The device's batteries provide power for 8–10h on a single charge and the sensor can be re-used many times after recharging the battery pack. A major advantage of the sensor over chromogenic filters for exposure monitoring is the collection of time-series data that allows users to better understand when and where individuals are exposed to highest ozone concentrations. The device may prove useful for industries requiring a low-cost solution to monitor employee exposure to ozone for specific work environments.
To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012."
A consensus committee of 55 international experts representing 25 international ...organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development.
The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable.
The Surviving Sepsis Guideline panel provided 93 statements on early management and resuscitation of patients with sepsis or septic shock. Overall, 32 were strong recommendations, 39 were weak recommendations, and 18 were best-practice statements. No recommendation was provided for four questions.
Substantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Objective
To provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012”.
Design
A consensus committee of 55 international experts representing 25 ...international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development.
Methods
The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable.
Results
The Surviving Sepsis Guideline panel provided 93 statements on early management and resuscitation of patients with sepsis or septic shock. Overall, 32 were strong recommendations, 39 were weak recommendations, and 18 were best-practice statements. No recommendation was provided for four questions.
Conclusions
Substantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
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