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zadetkov: 211
1.
  • Complement-mediated kidney ... Complement-mediated kidney diseases
    Poppelaars, Felix; Thurman, Joshua M. Molecular immunology, December 2020, 2020-12-00, 20201201, Letnik: 128
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    •Immune-complexes activate the classical pathway of complement in many forms of glomerulonephritis.•The alternative and lectin pathways are also activated in several forms of kidney ...
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2.
  • The Role of Complement in O... The Role of Complement in Organ Transplantation
    Grafals, Monica; Thurman, Joshua M Frontiers in immunology, 10/2019, Letnik: 10
    Journal Article
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    The current immunosuppressive protocols used in transplant recipients have improved short-term outcomes, but long-term allograft failure remains an important clinical problem. Greater understanding ...
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3.
  • Rhabdomyolysis and compleme... Rhabdomyolysis and complement—once again, epithelial cells take center stage
    Thurman, Joshua M. Kidney international, March 2021, 2021-03-00, 20210301, Letnik: 99, Številka: 3
    Journal Article
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    Rhabdomyolysis is frequently associated with kidney injury. Unfortunately, there are no specific treatments for this condition, and patient care primarily consists of supportive measures. In this ...
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4.
  • Developmental Fate and Cell... Developmental Fate and Cellular Maturity Encoded in Human Regulatory DNA Landscapes
    Stergachis, Andrew B.; Neph, Shane; Reynolds, Alex ... Cell, 08/2013, Letnik: 154, Številka: 4
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    Cellular-state information between generations of developing cells may be propagated via regulatory regions. We report consistent patterns of gain and loss of DNase I-hypersensitive sites (DHSs) as ...
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5.
  • Complement Therapeutics in ... Complement Therapeutics in Autoimmune Disease
    Thurman, Joshua M; Yapa, Roshini Frontiers in immunology, 04/2019, Letnik: 10
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    Many autoimmune diseases are characterized by generation of autoantibodies that bind to host proteins or deposit within tissues as a component of immune complexes. The autoantibodies can activate the ...
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6.
  • The Immune System and Idiop... The Immune System and Idiopathic Nephrotic Syndrome
    Campbell, Ruth E; Thurman, Joshua M Clinical journal of the American Society of Nephrology, 12/2022, Letnik: 17, Številka: 12
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    Idiopathic nephrotic syndrome often responds to immunosuppressive treatment. Nevertheless, this syndrome-and the drugs used to treat it-remain important causes of patient morbidity. Idiopathic ...
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7.
  • The Complement System and Antibody-Mediated Transplant Rejection
    Stites, Erik; Le Quintrec, Moglie; Thurman, Joshua M The Journal of immunology (1950), 12/2015, Letnik: 195, Številka: 12
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    Complement activation is an important cause of tissue injury in patients with Ab-mediated rejection (AMR) of transplanted organs. Complement activation triggers a strong inflammatory response, and it ...
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8.
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9.
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10.
  • All Things Complement All Things Complement
    Thurman, Joshua M; Nester, Carla M Clinical journal of the American Society of Nephrology, 10/2016, Letnik: 11, Številka: 10
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    The complement (C) cascade is an ancient system of proteins whose primary role is to initiate and modulate immune responses. During C activation, circulating proteins are cleaved and nascent cleavage ...
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