Three anti-EGF receptor MoAbs were used in these studies. Administration of MoAbs 3 and 176 inhibited tumor formation in nude mice by CNE-2, a poorly differentiated nasopharyngeal carcinoma cell line ...and A431, an epidermoid carcinoma cell line. When the same MoAbs were used in treatment against HeLa, a cervical carcinoma, tumor growth was not affected. The number of EGF receptors and apparent dissociation constants for 125I-EGF on CNE-2 and A431 was 1.3 x 10(5)/cell (Kd 7.7 x 10(-8) mol/L) and 1.4 x 10(6)/cell (Kd 2.4 x 10(-9) mol/L), respectively. Both MoAbs 3 and 176, capable of competing with EGF for receptor binding, showed significant tumor growth inhibition. MoAb 101 was incapable of blocking the binding of EGF to its receptor, and not as effective as MoAbs 3 and 176 in tumor growth inhibition. Our observation is that the MoAb anti-EGF receptor is cytostatic rather than cytocidal, in vitro against CNE-2 and A431.
The results of a high-statistics study of inclusive muon spectra at PETRA are reported. Improved mass limits have been obtained for heavy quarks, heavy leptons, and charged Higgs particles. It is ...shown that the fragmentation properties of b quarks and c quarks are different, with the mean fragmentation variables 〈zb〉=0.75±0.03±0.06, 〈zc〉=0.46±0.02±0.05 and the average semileptonic branching ratio for the B and C hadrons R(B)=(10.5±1.5±1.3)%, R(C)=(11.5±1.0±1.7)%.
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