As consultants for the largest enterprises in Slovenia, we found that even though the literature lists plenty of strategic information systems planning (SISP) methods with clear theoretical merits, ...the enterprises find these methods too abstract and/or too cumbersome to use in practice. To address this issue, we developed a new approach for the measurement of SISP success that attempts to combine key predictors of SISP success from the fields of strategic information systems planning and strategic business planning in a way that would be as practical as possible for everyday use in enterprises. We hope that our method will thus enable enterprises to validly, reliably and with greater ease measure and control the outcome of the SISP process by clearly defining the SISP success predictors that need to be monitored and by identifying the stakeholders responsible for their management. PUBLICATION ABSTRACT
A series of azaphenylalanine derivatives were investigated as novel thrombin inhibitors based on the prodrug principle. By systematic structural modifications we have identified optimal groups for ...this series that led us to potent inhibitors of thrombin incorporating the benzamidine fragment at the P1 position, and their potentially orally active benzamidoxime prodrugs. The binding modes in the thrombin active site of two representative compounds were identified by X-ray crystallographic analysis.
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The design, synthesis and biological activity of non-covalent thrombin inhibitors incorporating 4,5,6,7-tetrahydroindazole, 2-methyl-4,5,6,7-tetrahydroindazole, 4,5,6,7-tetrahydroisoindole, ...5,6,7,8-tetrahydroquinazoline and 5,6,7,8-tetrahydroquinazolin-2-amine as novel, partially saturated, heterobicyclic P(1)-arginine side-chain mimetics is described. The binding mode of the most potent candidate in the series co-crystallized with human alpha-thrombin, which exhibited an in vitro K(i) of 140nM and more that 478-fold selectivity against trypsin, is discussed.
The design, synthesis and biological activity of non-covalent thrombin inhibitors incorporating 4,5,6,7-tetrahydroindazole, 2-methyl-4,5,6,7-tetrahydroindazole, 4,5,6,7-tetrahydroisoindole, ...5,6,7,8-tetrahydroquinazoline and 5,6,7,8-tetrahydroquinazolin-2-amine as novel, partially saturated, heterobicyclic P
1-arginine side-chain mimetics is described. The binding mode of the most potent candidate in the series co-crystallized with human α-thrombin, which exhibited an in vitro
K
i of 140
nM and more that 478-fold selectivity against trypsin, is discussed.
The design, synthesis and biological activity of thrombin inhibitors incorporating novel non-basic partially saturated, heterobicyclic P
1-arginine side-chain mimetics is described.
Conjugated linoleic acid (CLA) has diverse influences on the immune response in different experimental models. In the present study we investigated the effect of CLA feeding on inflammatory and ...immune responses in a piglet model. We studied the duration of this effect and possible detrimental effects of CLA feeding. After 12 weeks of CLA and control supplementation and washout, animals were sacrificed and parenchymal organs were histologically examined.
In activated peripheral mononuclear cells interferon-gamma was significantly (p = 0.008) lower in the CLA group by the end of the feeding period. This effect disappeared as soon as supplementation was stopped. No differences were found in the tumour necrosis factor-alpha, interleukin-10 production, serum immunoglobulin-G levels and fat infiltration of the liver, except that fat storage cell infiltration was significantly (p < 0.04) higher in the CLA-fed group. The effect of time for interferon-gamma, interleukin-10 and immunoglobulin-G levels was statistically significant.
At the end of the feeding period the interferon-gamma response was depressed. However, the maturation of the piglet immune system in our young pig model probably outweighs the impact of CLA feeding on the immune response, even though liver fat storage cell infiltration, which plays an important role in liver regeneration, increased during CLA feeding of the piglets.
17ß-testosterone (testosterone) and 17ß-estradiol (estradiol), together with their synthetic analogues, have been banned in the EU as growth promoters for fattening purposes. A simple, reliable ...method for their detection in animals is therefore required. Levels of testosterone and estradiol in hair and plasma of Wistar rats have been determined, following intramuscular (i.m.) administration of tes
The design, synthesis and biological activity of a series of novel non-covalent D-Phe-Pro-Arg motif-based thrombin inhibitors incorporating 4,5,6,7-tetrahydrobenzothiazol-2-amine as a novel arginine ...surrogate are described. Compound
9, the most potent in the series of thrombin inhibitors, exhibited an in vitro
K
i of 128 nM and 342-fold selectivity against trypsin. The binding mode of this novel class of thrombin inhibitors in the enzyme active site, based on the X-ray crystal structure of compound
9 co-crystallized with human α-thrombin, is discussed.
An adult in Slovenia, who has partially or totally lost sight, is entitled to at least some basic aids and some financial assistance, which does not suffice for survival. Such a person, however, is ...not entitled to comprehensive rehabilitation, which would equip him/her for as independent living as possible and would emanate form the loss of sight per se. Therefore we are endeavoring to have this right enshrined in the legislation governing the system of public health.
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