The SARS-CoV-2 pandemic brought a radical shift in the healthcare system and suboptimal care for vulnerable patients, such as those with Type 2 Diabetes Mellitus (T2D). Therefore, we compared ...metabolic control and macro/microvascular complications of patients with T2D before and throughout the three-year SARS-CoV-2 pandemic.
A retrospective observational cohort of subjects with T2D studied from 2018 to 2022 in Northern Mexico was treated by a dynamic multidisciplinary team. Levels of Glycated hemoglobin (HbA1c), fasting serum glucose (FG), LDL-Cholesterol (LDL-C), blood pressure (BP), albuminuria, triglycerides, Body Mass Index (BMI), and FIB-4 score, micro and macrovascular complications were evaluated.
A total of 999 patients were studied, 51.7% males with a mean (SD) age of 60.1 (12.7) years. Adequate glycemic control based on HbA1c increased by 15.2% and 42.3% in FSG (p < 0.001) between the beginning 2018 and the end of 2022. LDL-C control decreased by 5.1% between 2018 and 2022 (p < 0.001). Systolic BP control decreased by 2.6% (p < 0.001), whereas diastolic BP control increased by 1.8% (p = 0.01) between 2018 and 2022. Albuminuria control increased by 8.5% (p = 0.002). When comparing the Area Under the Curve (AUC) of metabolic parameters between patients who developed SARS-CoV-2 vs. those who did not, AUC was statistically higher in those who developed SARS-CoV-2 (p < 0.05). Diabetic neuropathy was the most prevalent microvascular complication (n = 35; 3.6%); ischemic heart disease was the most frequent macrovascular complication (n = 11;1.1%).
A multidisciplinary dynamic team that adapts to the pandemic SARS-CoV-2 maintains and increases metabolic control in subjects with type 2 diabetes in Mexico. This represents a low percentage of chronic complications. The AUC of metabolic parameters of subjects with SARS-CoV-2 infection is higher, reflecting more variability in metabolic control.
Excess weight and obesity are major risk factors for many chronic diseases, and weight-loss interventions often include systematic exercise and nutritional supplements. The purpose of this study was ...to determine the independent/synergistic effects of
supplementation (six weeks, 4.5 g·day
) and a systematic physical exercise program (six weeks, twice weekly) on the body composition and cardiorespiratory fitness of overweight and obese subjects. To achieve this, 27 overweight and 25 obese sedentary male subjects were assigned to four interventions through a randomized double-blind, crossover controlled trial: A physical exercise program, with (SE) or without (Ex)
; or no-exercise program, with (Sm) and without (C)
. The body composition and cardiorespiratory fitness parameters were taken during a maximum intensity test. As compared to the C group, the body fat percentage of the SE, Sm and Ex groups was reduced (
< 0.05), while their maximal oxygen uptake improved (
= -0.40), and obese subjects benefited more significantly. Weight loss, the time to reach fatigue and the onset of blood lactate accumulation were improved in both of the
supplemented groups, regardless of the subjects' body weight.
supplementation synergistically improves the effects of systematic exercise on body composition and cardiorespiratory fitness parameters in overweight, but mostly in individuals with obesity.
Clinical Trials, NCT02837666. Registered 19 July 2016.
The maximal fat oxidation rate (MFO) assessed during a graded exercise test is a remarkable physiological indicator associated with metabolic flexibility, body weight loss and endurance performance. ...The present review considers existing biomarkers related to MFO, highlighting the validity of maximal oxygen uptake and free fatty acid availability for predicting MFO in athletes and healthy individuals. Moreover, we emphasize the role of different key enzymes and structural proteins that regulate adipose tissue lipolysis (i.e., triacylglycerol lipase, hormone sensitive lipase, perilipin 1), fatty acid trafficking (i.e., fatty acid translocase cluster of differentiation 36) and skeletal muscle oxidative capacity (i.e., citrate synthase and mitochondrial respiratory chain complexes II–V) on MFO variation. Likewise, we discuss the association of MFO with different polymorphism on the ACE, ADRB3, AR and CD36 genes, identifying prospective studies that will help to elucidate the mechanisms behind such associations. In addition, we highlight existing evidence that contradict the paradigm of a higher MFO in women due to ovarian hormones activity and highlight current gaps regarding endocrine function and MFO relationship.
Low-fat diets, lipid-modifying nutraceuticals and a higher level of physical activity are often recommended to reduce dyslipidemia. A double-blind, randomized, crossover, controlled trial was ...designed to evaluate the independent and synergistic effects of
(
)
supplementation (4.5 g·day
) with or without performing a physical exercise program (
: aerobic exercise (3 days·week
) + high-intensity interval training (2 days·week
)) on blood lipids and BMI of 52 sedentary men with excess body weight. During six weeks, all participants were assigned to four intervention treatments (
with PEP (SE), placebo with PEP (Ex),
without PEP (Sm), placebo without PEP (C; control)) and plasma lipids were evaluated spectrophotometrically pre- vs. post intervention in stratified subgroups (overweight, obese and dyslipidemic subjects). Pre/post comparisons showed significant reductions in all plasma lipids in the SE group, particularly in those with dyslipidemia (
≤ 0.043). Comparing the final vs. the initial values, BMI, total cholesterol, triglycerides and low-density lipoprotein cholesterol were decreased. High-density lipoprotein cholesterol increased in all treatment groups compared to C. Changes were observed mostly in SE interventions, particularly in dyslipidemic subjects (
< 0.05).
supplementation enhances the hypolipidemic effect of a systematic PEP in men with excess body weight and dyslipidemia.
Purpose: This work studies the interrelation of the first ventilatory threshold (VT1), the heart rate inflection point (HRIP), and the exercise intensity at which blood lactate started to accumulate ...(LIAB) or increased 1 mmol∙L-1 above baseline (LT+1.0); and examinee their association with the exercise intensity eliciting maximal fat oxidation (FATmax). Methods: Eighteen young men with obesity performed an incremental-load exercise test on a treadmill after overnight fasting. Gas exchange, heart rate, and blood lactate concentration were recorded. Linear regression analysis was used to determine the association among FATmax and AeT markers. A standard error of estimate (SEE) ≤9 beats∙min-1 and the concordance correlation coefficient (CCC) were used to examine the accuracy of different AeT for predicting FATmax heart rate. Results: The FATmax occurred at 36±7%VO2peak before the HRIP (41±6%VO2peak), LIAB (42±10%VO2peak), LT+1.0 (61±9%VO2peak) and VT1 (40±7%VO2peak). Furthermore, the HRIP (R2= 0.71; SEE= 6 beats∙min-1; CCC=0.77), VT1 (R2= 0.76; SEE= 5 beats∙min-1; CCC=0.84) and LIAB (R2= 0.77; SEE= 5 beats∙min-1; CCC=0.85) were strongly associated to FATmax and showed an acceptable estimation error for predicting FATmax heart rate. Otherwise, LT+1.0 showed a moderate correlation with FATmax, a low accuracy for predicting FATmax HR (R2= 0.57; SEE= 7 beats∙min-1; CCC=0.66) and a poor agreement with the rest of AeT markers (Bias: +20%VO2peak). Conclusion: The HRIP, LIAB and VT1 did not perfectly captured the FATmax, however, these could be exchanged for predicting the FATmax heart rate in men with obesity. Moreover, the LT+1.0 should not be used for AeT or FATmax assessment in men with obesity.
A body mass index (BMI) ≥30 kg/m(2) and a waist circumference (WC) ≥80 cm in women (WCF) or ≥90 cm in men (WCM) are reference cardiometabolic risk markers (CMM) for Mexicans adults. However, their ...reliability to predict other CMM (index tests) in young Mexicans has not been studied in depth.
A cross-sectional descriptive study evaluating several anthropometric, physiological and biochemical CMM from 295 young Mexicans was performed. Sensitivity (Se), specificity (Sp) and Youden's index (J) of reference BMI/WC cutoffs toward other CMM (n = 14) were obtained and their most reliable cutoffs were further calculated at Jmax.
Prevalence, incidence and magnitude of most CMM increased along the BMI range (p < 0.01). BMI explained 81 % of WC's variance Se (97 %), Sp (71 %), J (68 %), Jmax (86 %), BMI = 30 kg/m(2) and 4-50 % of other CMM. The five most prevalent (≥71 %) CMM in obese subjects were high WC, low HDL-C, and three insulin-related CMM Fasting insulin, HOMA-IR, and QUICKI. For a BMI = 30 kg/m(2), J ranged from 16 % (HDL-C/LDL-C) to 68 % (WC), being moderately reliable (Jmax = 61-67) to predict high uric acid (UA), metabolic syndrome (MetS) and the hypertriglyceridemic-waist phenotype (HTGW). Corrected WCM/WCF were moderate-highly reliable (Jmax = 66-90) to predict HTGW, MetS, fasting glucose and UA. Most CMM were moderate-highly predicted at 27 ± 3 kg/m(2) (CI 95 %, 25-28), 85 ± 5 cm (CI 95 %, 82-88) and 81 ± 6cm (CI 95 %, 75-87), for BMI, WCM and WCF, respectively.
BMI and WC are good predictors of several CMM in the studied population, although at different cutoffs than current reference values.
Cardiovascular diseases are part of the highly preventable chronic diseases associated with changes in lifestyle. Within them, physical activity, low-fat and high-fiber diets are distinguished as the ...main support for prevention, even when supplementation with nutraceuticals has become a very common practice. Fifty-two young sedentary men with excess body weight (body mass index (BMI) ≥ 25 kg·m
) were enrolled in a randomized-crossover controlled trial six weeks of a systematic physical exercise with
or placebo supplementation (4.5 g·day
). Body composition, blood lipid profile, and maximal oxygen uptake were determined pre/post intervention. Pairwise comparisons showed a significant improvement (
< 0.01) on blood lipid profile in the group of exercise plus
. Moreover, correlations of absolute changes of BMI, body fat percentage, blood lipids and maximal oxygen uptake were statistically significant (
< 0.01). These results indicate that the
supplementation could be acting in a synergistic way with exercise due to the enhanced effects on body composition, cardiorespiratory fitness, and blood lipid profile. This phenomenon should be considered to reduce risk of cardiovascular disorders. Trial registration: Clinical Trials, NCT02837666 (July 19, 2016).
Body shape as body image determinant in university students Ramos-Jiménez, Arnulfo; Hernández Torres, Rosa P; Wall Medrano, Abraham ...
Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral,
2017-Oct-24, Letnik:
34, Številka:
5
Journal Article
Odprti dostop
Body shape (BSP) and body image (BI) are part of the external physical structure, then modifications in body shape necessarily affect body image; however, both combined have not been studied. The ...purpose of the study was to evaluate the statistical relationship between BSP and BI in university students.
Two hundred and ninety-six participants (17-35 years) were included in this study. Different anthropometric measurements were used to define their somatotype (BSP), body mass index (BMI), waist to hip ratio (WHR) and waist circumference (WC). In addition, a questionnaire on body image perception was applied (McElhone et al.), regarding "how do I look?", "how do I think others see me?", "how do others see me?", and "how do I want to look like?".
On average, men perceived themselves in normal weight; in contrast, women perceived themselves as overweight. Men were meso-endomorphic, while women were endo-mesomorphic as an average.
Body shape measured as somatotype as well as WC and WHR were excellent determinants of body image. Participants who presented a higher endomorphy, WC and WHR and a lower ectomorphy had a higher appreciation of being overweight or obese and wish to become thinner.
This study investigates the immediate effects of acute postural exercises on the stature of seniors, focusing on changes in both upright and supine stature measurements. A within-subject design with ...repeated measures was applied, involving seniors participating in continuous exercises aimed at enhancing core musculature strength and promoting muscle relaxation. Stature measurements were recorded pre- and post-exercise in both upright and supine positions, alongside assessments of body mass index (BMI) category classifications. The results revealed a post-exercise increase in stature ranging from 0.9 to 6.0 cm and from 0.2 to 7.2 cm in upright and supine positions, respectively, with an average increase of approximately 3.5 cm in both upright and supine positions. Statistically significant and clinically relevant changes were observed (
< 0.05), including a modification of BMI by approximately two units, reclassifying 55% of participants from overweight or obese to normal weight or overweight. Furthermore, the similarity between post-exercise upright stature and pre-exercise supine stature suggested that the supine position might provide a more accurate measure of stature in seniors. Conclusively, acute postural exercises have an immediate positive impact on the stature of seniors, suggesting their potential utility in clinical settings for accurate stature measurement. However, BMI results should be interpreted with caution because they are only related to the acute change in stature and therefore may lead to the misinterpretation of the study findings, so future studies focused on evaluating the chronic effect of postural exercises integration on the health outcomes of older adults are needed to demonstrate their potential utility in clinical settings to improve postural health and general well-being.
Although it is common to measure bone lengths for study, methodological errors in data measurement and processing often invalidate their clinical and scientific usefulness. This manuscript reviews ...the validity of several published equations used to determine the maximum height in older adults, since height is an anthropometric parameter widely employed in health sciences. A systematic review of original articles published in the English, Spanish, or Portuguese languages was performed in PubMed, ScienceDirect, EBSCO, Springer Link, and two institutional publisher integrators (UACJ and CONRICYT). The search terms were included in the metasearch engines in a combined way and text form using the Boolean connectors AND and OR {(Determination OR Estimation OR Equation) AND Height AND (Elderly OR "Older adults")}. Eleven manuscripts were selected from 1935 records identified through database searching after applying the following criteria: (1) original articles that designed and validated equations for the determination of height by anthropometric methods in adults 60 years of age and older and (2) manuscripts that presented robust evidence of validation of the proposed regression models. The validity of the reported linear regression models was assessed throughout a manuscript review process called multi-objective optimization that considered the collection of the models, the prediction errors, and the adjustment values (i.e., R
, standard error of estimation, and pure error). A total of 64 equations were designed and validated in 45,449 participants (57.1% women) from four continents: America (85.3%, with 46 equations), Asia (8.1%, with 10), Europe (4.6%, with 7), and Africa (2.0%, with 1); the Hispanic American ethnic group was the most numerous in participants and equations (69.0%, with 28). Due to various omissions and methodological errors, this study did not find any valid and reliable equations to assess the maximum height in older adults by anthropometric methods. It is proposed to adjust allometric mathematical models that can be interpreted in the light of ontogenetic processes.
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