S 872419 A, a specific receptor antagonist of peptide leukotrienes, was tested in the early-phase treatment of chemically burned eye (0.25 mol/l sodium hydroxide) of the rabbit. The drug was ...topically applied 5 times a day in a 1% solution, controls were the untreated opposite eye. Gross and microscopic investigations indicated that S 872419 A inhibits the inflammatory response of the chemically burned anterior eye segment. The parameters of healing considered (epithelial regeneration, corneal clouding and swelling, infiltration with polymorphonuclear leukocytes) suggest inhibition of lipoxygenase-mediated reactions in the tissue. PGF2 alpha levels were the same in aqueous humour of treated and untreated eyes. Further experiments with S 872419 A and other nonsteroidal drugs should improve the anti-inflammatory therapy of the chemically burned eye.
A decisive condition for the clarification of malformations and degenerations is knowledge of the pre- and postnatal development. Therefore investigations were undertaken to determine the plan and ...lay-out of the eye-lids in an hairloss mutant of mouse.
Biomicroscopical and histological investigations were carried out in 51 hl-mice from the 10th day of gestation unto the birth. This particular mouse is a spontaneous hairloss mutant, in which corneal degenerations also occur.
On the 11th day of gestation the ectodermal dips may be distinguished, as well as the shoe-lace-like furrows around the eye-ball, which indicate the development of the eyelids. The upper and lower lid are formed by proliferation. The fusion of the eyelids is completed around the 16th day of gestation.
The eyelid development starts in mice between the 11th and 14th day of gestation. The fusion is completed on day 15-17. The morphogenesis of the eyelid development will be discussed.
Wyburn-Mason syndrome Tost, F; Weidlich, R; Tost, M
Klinische Monatsblätter für Augenheilkunde
208, Številka:
2
Journal Article
Recenzirano
There are various malformations of retinal vessels. Some of them are associated with cerebral vascular anomalies.
This report is given on a girl 6 years of age with a retinal racemose angioma.
The ...clinical examination showed a unilateral racemose angioma combined with retinachorioidal anastomosis and a hemifacial vascular malformation. We found teleangiectasia in this area. The ophthalmoscopy demonstrated a blurred border of optic disc on the right eye with forward protrusion of the disc about + 2.0 dioptres. Large racemose lesions may be localized to the optic nerve and may involve segmental areas of the macula. The ultrasound showed a papillary stasis with highly reflective structures. The ultrasonic patterns are interpreted as a cholesterosis or fibrovascular tissue. This findings may belong to the rare Wyburn-Mason syndrome. Acute neurological symptoms by similar lesions the midbrain and hemorrhages during extraction of teeth are reported in literature.
