Features of the DUNE deep underground neutrino accelerator experiment will enable scientists to complete the studying of three-flavor neutrino oscillations within the extended Standard Model. In this ...paper, it is considered how sensitive DUNE will be to the determination of weakly measured or almost unknown neutrino oscillation parameters. The dependencies of the significance level on the true values of the charge-parity phase
to the definition of the neutrino mass ordering and the conservation or breaking of the charge-parity symmetry are shown. A simulation was carried out in two software environments created for oscillation analysis—GLoBES and GNA. Since this analysis in GNA is implemented for the first time, the authors have previously developed a shell that can calculate the number of events, build histograms of oscillated channels, and calculate the sensitivities for DUNE and for other accelerator experiments. It was found that after 7 yr of experiment operation the neutrino mass ordering will be determined at a significance level greater than
for all values of
, after 10 yr of experiment operation—for 50% values of
at a significance level
will be determined whether CP-symmetry breaking exists in the lepton sector.
The last unknown neutrino mixing angle has been successfully measured by the Daya Bay, RENO and Double Chooz experiments. The used oscillation probability formula is based on the plane-wave model. A ...wave-packet model is necessary for a self-consistent description of neutrino oscillations. The oscillation probability formula in the wave-packet model describes effects missing in the plane-wave approximation, such as delocalization, decoherence and dispersion which all depend on a single unknown parameter σp - momentum dispersion of the neutrino wave-packet. The survival probability formula in the wave-packet model was used to fit the Daya Bay data. The high-statistics data set of reactor ν ¯ e interactions in the Daya Bay experiment allows us to study the neutrino oscillation in the wave-packet model and provide the first experimental constraint of σp. Some results of our study are reported in this paper.
On the basis of the fact that the amplitude of elastic pp scattering is well described in the high energy region by the contribution of a dipole pomeron and an odderon, the profile function is ...calculated in this approximation and its behavior is investigated in the region of small impact parameters. It is shown that the profile function in this region does not have any singularities, and they arise only in the limit of small phase volumes (i.e., as the Planck constant tends to zero ħ → 0). The behavior of the elastic cross section and of
as s → ∞ is investigated. It is shown that these characteristics increase as the logarithm of the energy ratio
.
Diabetic patients develop a cardiomyopathy that consists of ventricular hypertrophy and diastolic dysfunction. Although the pathogenesis of this condition is poorly understood, previous studies ...implicated abnormal G-protein activation. In this work, mice with cardiac overexpression of the transcription factor peroxisome proliferator-activated receptor-alpha (PPAR-alpha) were examined as a model of diabetic cardiomyopathy. PPAR-alpha transgenic mice develop spontaneous cardiac hypertrophy, contractile dysfunction, and "fetal" gene induction. We examined the role of abnormal G-protein activation in the pathogenesis of cardiac dysfunction by crossing PPAR-alpha mice with transgenic mice with cardiac-specific overexpression of regulator of G-protein signaling subtype 4 (RGS4), a GTPase activating protein for Gq and Gi. Generation of compound transgenic mice demonstrated that cardiac RGS4 overexpression ameliorated the cardiomyopathic phenotype that occurred as a result of PPAR-alpha overexpression without affecting the metabolic abnormalities seen in these hearts. Next, transgenic mice with increased or decreased cardiac Gq signaling were made diabetic by injection with streptozotocin (STZ). RGS4 transgenic mice were resistant to STZ-induced cardiac fetal gene induction. Transgenic mice with cardiac-specific expression of mutant Galphaq, Galphaq-G188S, that is resistant to RGS protein action were sensitized to the development of STZ-induced cardiac fetal gene induction and bradycardia. These results establish that Gq-mediated signaling plays a critical role in the pathogenesis of diabetic cardiomyopathy.
Varieties of alcoholic abstinence Anufriev, A K; Treskov, V G
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
1984, Letnik:
84, Številka:
2
Journal Article
On the basis of the evidence obtained from a clinical-psychopathological study of 154 patients with chronic alcoholism, four types of the abstinence syndrome were specified, including 1) ordinary ...nonpsychotic astheno-vegetative dysthymia; 2) an astheno-melancholic reaction as exogenically resolved "soil depression"; 3) a depressive-vegetative cyclothymic reaction or phase; 4) a schizothymovegetative reaction or exacerbation of an uneventful schizophrenic shift.
Radioimmunoassay was used to measure the blood content of beta-endorphines in patients with chronic alcoholism. The concentration of endogenous ethanol in these patients was determined by gas ...chromatography. The blood concentration of beta-endorphines was found to be high in patients who showed atypical affective disorders off the period of abstinence. It is assumed that peripheral beta-endorphine is not linked with the development of the narcomanic syndrome proper but mirrors the pathogenetic mechanisms of psychopathological disorders. The levels of endogenous ethanol vary in alcoholics and healthy subjects within the same ranges. However, the percentage distribution indicates that in patients, they are shifted toward lower concentrations, which is likely to be conditioned by the induction of enzymatic systems that metabolize ethanol.
Sodium salt of gamma-hydroxybutyric acid (Na-GHB) was administered to 37 drug-free alcoholic men in placebo controlled study. The psychotropic effect was evaluated using psychometric scale of 4 ...ranges. Changes in plasma levels of epinephrine, norepinephrine, dopamine, serotonin and platelet MAO-B activity were assessed. The psychotropic effect was observed in 27 (76%) patients. The baseline of dopamine concentration was significantly correlated with the expression of psychotropic effect. Na-GHB decreased dopamine concentration in responders. The possible involvement of dopaminergic system in the realization of psychotropic effect of Na-GHB was discussed.
Clinical pharmacokinetics of mebikar Serov, N V; Treskov, V G; Berliand, A S ...
Farmakologiia i toksikologiia,
1984 May-Jun, Letnik:
47, Številka:
3
Journal Article
Twenty-two patients admitted to the narcological clinic of an industrial enterprise were examined for the clinical effect and pharmacokinetic parameters after intake of a single dose of a Soviet ...psychotropic drug mebicar. The clinical status was assessed by means of psychometric mapping and concurrent recording of the EEG. The correlation of the pharmacodynamic and pharmacokinetic data can be used for the choice of minimal effective concentrations applied in further calculations of individual dosage regimens.
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