A biopharmaceutic–pharmacodynamic model is proposed to characterize the antiproliferative effect of controlled release formulations of cisplatin in cancer cell culture. In vitro release profiles from ...PLGA poly(
d,
l-lactide-co-glycolide) systems were described using a model based on the characterization of two drug release processes: diffusion and matrix degradation. Cytotoxicity data available consisting of the number of survival cells after a continuous exposure to free or encapsulated cisplatin were simultaneously modeled under the Gompertz framework incorporating the drug release model.
The release model parameters showed that particle size was inversely related to the diffusion rate. The antiproliferative effect was described as a function of drug concentrations and exposure times. Two mechanisms were included: (i) an inhibition of cell proliferation, where cisplatin released from PLGA systems was mainly involved, followed by (ii) stimulation of cell death due to cisplatin activity and mediated by the activation of a signal transduction process. Cell accumulation in G2/M phase of the cell cycle followed by the activation of caspase-3, supported both mechanisms.
The selected drug-effect model and its model parameters were independent from the formulation, which makes it a suitable tool to explore
in silico, alternative in vitro and in vivo scenarios to optimize these delivery systems.
The Compact Muon Solenoid (CMS) experiment prepares its Phase-2 upgrade for the high-luminosity era of the LHC operation (HL-LHC). Due to the increase of occupancy, trigger latency and rates, the ...full electronics of the CMS Drift Tube (DT) chambers will need to be replaced. In the new design, the time bin for the digitization of the chamber signals will be of around 1 ns, and the totality of the signals will be forwarded asynchronously to the service cavern at full resolution. The new backend system will be in charge of building the trigger primitives of each chamber. These trigger primitives contain the information at chamber level about the muon candidates position, direction, and collision time, and are used as input in the L1 CMS trigger. The added functionalities will improve the robustness of the system against ageing. An algorithm based on analytical solutions for reconstructing the DT trigger primitives, called Analytical Method, has been implemented both as a software C++ emulator and in firmware. Its performance has been estimated using the software emulator with simulated and real data samples, and through hardware implementation tests. Measured efficiencies are 96 to 98% for all qualities and time and spatial resolutions are close to the ultimate performance of the DT chambers. A prototype chain of the HL-LHC electronics using the Analytical Method for trigger primitive generation has been installed during Long Shutdown 2 of the LHC and operated in CMS cosmic data taking campaigns in 2020 and 2021. Results from this validation step, the so-called Slice Test, are presented.
A search for a heavy resonance decaying into a top quark and a W boson in proton-proton collisions at $ \sqrt{s} $ = 13 TeV is presented. The data analyzed were recorded with the CMS detector at the ...LHC and correspond to an integrated luminosity of 138 fb$^{−1}$. The top quark is reconstructed as a single jet and the W boson, from its decay into an electron or muon and the corresponding neutrino. A top quark tagging technique based on jet clustering with a variable distance parameter and simultaneous jet grooming is used to identify jets from the collimated top quark decay. The results are interpreted in the context of two benchmark models, where the heavy resonance is either an excited bottom quark b$^{∗}$ or a vector-like quark B. A statistical combination with an earlier search by the CMS Collaboration in the all-hadronic final state is performed to place upper cross section limits on these two models. The new analysis extends the lower range of resonance mass probed from 1.4 down to 0.7 TeV. For left-handed, right-handed, and vector-like couplings, b$^{∗}$ masses up to 3.0, 3.0, and 3.2 TeV are excluded at 95% confidence level, respectively. The observed upper limits represent the most stringent constraints on the b$^{∗}$ model to date.graphic not available: see fulltext
In this case report, we describe a tawny owl chick (Strix aluco) coming from a Wild Fauna Recovery Center with multiple congenital malformations in the limbs. The animal was unable to fly and showed ...marked malnutrition and poor general appearance. Physical, radiologic, and anatomic examinations showed osseous malformations including dislocation of radius and carpometacarpus with abnormal nonfunctional fixation of ligamentum propatagialis, absence of most parts of the bones of the manus in both wings, and twisted nonfused left tarsometatarsus with marked griphosis of digits. Routine toxicologic and pathologic examinations did not reveal a specific etiology.
We propose a new collider probe for axion-like particles (ALPs), and more generally for pseudo-Goldstone bosons: non-resonant searches which take advantage of the derivative nature of their ...interactions with Standard Model particles. ALPs can participate as off-shell mediators in the \(s\)-channel of \(2 \to 2\) scattering processes at colliders like the LHC. We exemplify the power of this novel type of search by deriving new limits on ALP couplings to gauge bosons via the processes \(p p \to Z Z\), \(p p \to \gamma \gamma\) and \(p p \to j j\) using Run 2 CMS public data, probing previously unexplored areas of the ALP parameter space. In addition, we propose future non-resonant searches involving the ALP coupling to other electroweak bosons and/or the Higgs particle.
Two drift tubes (DTs) chambers of the CMS muon barrel system were exposed to a 40
MHz bunched muon beam at the CERN SPS, and for the first time the whole CMS Level-1 DTs-based trigger system chain ...was tested. Data at different energies and inclination angles of the incident muon beam were collected, as well as data with and without an iron absorber placed between the two chambers, to simulate the electromagnetic shower development in CMS. Special data-taking runs were dedicated to test for the first time the Track Finder system, which reconstructs track trigger candidates by performing a proper matching of the muon segments delivered by the two chambers. The present paper describes the results of these measurements.
Fine synchronization of the CMS muon drift tubes local trigger Aldaya, M.; Amapane, N.; Battilana, C. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
08/2006, Letnik:
564, Številka:
1
Journal Article
Recenzirano
The drift tubes based CMS barrel muon trigger, which uses self-triggering arrays of drift tubes, is able to perform the identification of the muon parent bunch crossing using a rather sophisticated ...algorithm. The identification is unique only if the trigger chain is correctly synchronized. Some beam test time was devoted to take data useful to investigate the synchronization of the trigger electronics with the machine clock. Possible alternatives were verified and the dependence on muon track properties was studied.
PDF
