Problems with emotion regulation and behavior are often reported in children with autism spectrum disorders (ASD). This pilot study examined the effect of physical exercise on emotion regulation and ...behavioral functioning in children with ASD. Twenty-seven children aged 8–12 years were randomized into either an exercise intervention group (n = 15) or a control group (n = 12). The intervention group received a 12-week jogging intervention. Children’s parents completed the Emotion Regulation Checklist and the Child Behavior Checklist pre- and post-intervention. The intervention group demonstrated significant improvement in emotion regulation and reduction in behavioral problems (
p
s < .05). Future studies should explore the mechanisms underlying the effects of physical exercise on emotion regulation and behavior in children with ASD.
This brief review of the human Na/H exchanger gene family introduces a new classification with three subgroups to the SLC9 gene family. Progress in the structure and function of this gene family is ...reviewed with structure based on homology to the bacterial Na/H exchanger NhaA. Human diseases which result from genetic abnormalities of the SLC9 family are discussed although the exact role of these transporters in causing any disease is not established, other than poorly functioning NHE3 in congenital Na diarrhea
An achievable bit rate per source-destination pair in a wireless network of n randomly located nodes is determined adopting the scaling limit approach of statistical physics. It is shown that ...randomly scattered nodes can achieve, with high probability, the same 1/radicn transmission rate of arbitrarily located nodes. This contrasts with previous results suggesting that a 1/radicnlogn reduced rate is the price to pay for the randomness due to the location of the nodes. The network operation strategy to achieve the result corresponds to the transition region between order and disorder of an underlying percolation model. If nodes are allowed to transmit over large distances, then paths of connected nodes that cross the entire network area can be easily found, but these generate excessive interference. If nodes transmit over short distances, then such crossing paths do not exist. Percolation theory ensures that crossing paths form in the transition region between these two extreme scenarios. Nodes along these paths are used as a backbone, relaying data for other nodes, and can transport the total amount of information generated by all the sources. A lower bound on the achievable bit rate is then obtained by performing pairwise coding and decoding at each hop along the paths, and using a time division multiple access scheme
The capacity of the two-user Gaussian interference channel has been open for 30 years. The understanding on this problem has been limited. The best known achievable region is due to Han and Kobayashi ...but its characterization is very complicated. It is also not known how tight the existing outer bounds are. In this work, we show that the existing outer bounds can in fact be arbitrarily loose in some parameter ranges, and by deriving new outer bounds, we show that a very simple and explicit Han-Kobayashi type scheme can achieve to within a single bit per second per hertz (bit/s/Hz) of the capacity for all values of the channel parameters. We also show that the scheme is asymptotically optimal at certain high signal-to-noise ratio (SNR) regimes. Using our results, we provide a natural generalization of the point-to-point classical notion of degrees of freedom to interference-limited scenarios.
In a wireless network with a single source and a single destination and an arbitrary number of relay nodes, what is the maximum rate of information flow achievable? We make progress on this long ...standing problem through a two-step approach. First, we propose a deterministic channel model which captures the key wireless properties of signal strength, broadcast and superposition. We obtain an exact characterization of the capacity of a network with nodes connected by such deterministic channels. This result is a natural generalization of the celebrated max-flow min-cut theorem for wired networks. Second, we use the insights obtained from the deterministic analysis to design a new quantize-map-and-forward scheme for Gaussian networks. In this scheme, each relay quantizes the received signal at the noise level and maps it to a random Gaussian codeword for forwarding, and the final destination decodes the source's message based on the received signal. We show that, in contrast to existing schemes, this scheme can achieve the cut-set upper bound to within a gap which is independent of the channel parameters. In the case of the relay channel with a single relay as well as the two-relay Gaussian diamond network, the gap is 1 bit/s/Hz. Moreover, the scheme is universal in the sense that the relays need no knowledge of the values of the channel parameters to (approximately) achieve the rate supportable by the network. We also present extensions of the results to multicast networks, half-duplex networks, and ergodic networks.
Summary
Background
Metabolic syndrome is a known risk factor of cirrhosis in chronic hepatitis B (CHB).
Aim
To investigate the effects of coincidental metabolic syndrome on liver fibrosis progression ...in treatment‐naïve CHB patients.
Methods
A total of 1466 CHB patients underwent liver stiffness measurement (LSM) by transient elastography in 2006–2008; 663 patients remained treatment‐naïve and had second LSM in 2010–2012. Liver fibrosis progression was defined as an increase in LSM ≥30% at the second assessment. The impact of coincidental metabolic syndrome and its factors on liver fibrosis progression were evaluated after adjustment for viral load and hepatitis activity.
Results
At baseline, the mean age was 43 ± 12 years, 55% were males, serum alanine aminotransferase (ALT) was 44 ± 40 IU/L, HBV DNA was 4.0 ± 2.0 log IU/mL and LSM was 6.3 ± 3.6 kPa. Metabolic syndrome was diagnosed in 80 (12%) and 142 (21%) patients at baseline and follow‐up visit, respectively; 84 (13%) and 22 (3%) patients had coincidental and resolved metabolic syndrome respectively. After an interval of 44 ± 7 months, 107 (16%) patients developed liver fibrosis progression. Coincidental metabolic syndrome adjusted odds ratio (aOR) 2.0, 95% confidence interval (CI) 1.1–3.5, P = 0.015, central obesity (aOR 2.0, 95% CI 1.0–4.1, P = 0.05) and low level of high‐density lipoprotein cholesterol (aOR 1.9, 95% CI 1.0–3.7, P = 0.04) were associated with liver fibrosis progression independent of change in viral load and ALT level. The effects of coincidental metabolic syndrome were most apparent in the immune‐tolerant phase.
Conclusion
Coincidental metabolic syndrome increases the risk of liver fibrosis progression in patients with chronic hepatitis B infection, independent of viral load and hepatitis activity.
Downlink Interference Alignment Changho Suh; Ho, Minnie; Tse, D. N. C.
IEEE transactions on communications,
09/2011, Letnik:
59, Številka:
9
Journal Article
Recenzirano
We develop an interference alignment (IA) technique for a downlink cellular system. In the uplink, IA schemes need channel-state-information exchange across base-stations of different cells, but our ...downlink IA technique requires feedback only within a cell. As a result, the proposed scheme can be implemented with a few changes to an existing cellular system where the feedback mechanism (within a cell) is already being considered for supporting multi-user MIMO. Not only is our proposed scheme implementable with little effort, it can in fact provide substantial gain especially when interference from a dominant interferer is significantly stronger than the remaining interference: it is shown that in the two-isolated cell layout, our scheme provides four-fold gain in throughput performance over a standard multi-user MIMO technique. We also show through simulations that our technique provides respectable gain under a more realistic scenario: it gives approximately 28% gain for a 19 hexagonal wrap-around-cell layout. Furthermore, we show that our scheme has the potential to provide substantial gain for macro-pico cellular networks where pico-users can be significantly interfered with by the nearby macro-BS.
Summary
Background
Patients with nonalcoholic steatohepatitis (NASH) have gut dysbiosis and intestinal bacterial overgrowth.
Aim
To test the hypothesis that endotoxemia is associated with the ...histological severity of nonalcoholic fatty liver disease (NAFLD) and determine factors associated with endotoxemia.
Methods
The endotoxemia markers lipopolysaccharide‐binding protein (LBP) and endotoxin levels were measured in 237 NAFLD patients 1 day before liver biopsy. Biomarkers of liver injury and transient elastography were performed as additional markers of disease severity.
Results
A total of 114/237 (48%) patients had NASH and 80/237 (34%) had F2‐4 fibrosis. LBP was correlated with lobular inflammation (P=.001), while both LBP (P=.0004) and endotoxin levels (P=0.008) were correlated with fibrosis. LBP was also correlated with cytokeratin‐18 fragments (P=.002) and aspartate aminotransferase‐to‐alanine aminotransferase ratio (P=.006), and both LBP (P=.019) and endotoxin (P=.006) were correlated with liver stiffness measurement by transient elastography. LBP was increased in patients with NASH (15.3±4.6 vs 13.8±3.3 μg/mL; P=.005) and F2‐4 fibrosis (15.4±4.4 vs 14.0±3.7 μg/mL; P=.008). Interestingly, patients harbouring the TM6SF2 rs58542926 T allele that predispose to NAFLD/NASH had higher LBP level. By multivariate analysis, gender, higher body mass index and glycated haemoglobin, and TM6SF2 variants were independent factors associated with increased LBP level.
Conclusions
Endotoxemia is positively associated with NASH and significant fibrosis. The association between TM6SF2 and endotoxemia warrants further investigations. The findings may shed light on the pathogenesis of NASH and inform a novel treatment target.
Linked ContentThis article is linked to Valenti and Romeo paper. To view this article visit https://doi.org/10.1111/apt.14154.
Background. Better understanding of complications and outcomes of adults hospitalized with respiratory syncytial virus (RSV) infection is necessary. Methods. A retrospective cohort study was ...conducted on all adults (≥18 years) admitted to 3 acute care general hospitals in Hong Kong with virologically confirmed RSV infection during 2009–2011 (N = 607). Adults hospitalized for seasonal influenza during the period were used for comparison (n = 547). Both infections were prospectively diagnosed following a standard protocol. Independent reviews of chest radiographs were performed by radiologists. Main outcome measures were all-cause death, respiratory failure requiring ventilatory support, and hospitalization duration. Cox proportional hazards models were used for analyses. Results. The mean age of RSV patients was 75 (SD, 16) years; 87% had underlying conditions. Lower respiratory and cardiovascular complications were diagnosed in 71.9% (pneumonia, 42.3%; acute bronchitis, 21.9%; chronic obstructive pulmonary disease/asthma exacerbation, 27.3%) and 14.3% of patients, respectively; 12.5% had bacterial superinfections. Supplemental oxygen and ventilatory support were required in 67.9% and 11.1%, respectively. Crude all-cause mortality was 9.1% and 11.9% within 30 days and 60 days, respectively; mean length of stay of survivors was 12 (SD, 13) days. Advanced age, radiographic pneumonia, requirement for ventilation, bacterial superinfection, and elevated urea level and white blood cell count were independently associated with poorer survival. Systemic corticosteroid use was associated with longer hospitalization and secondary infections. The overall outcomes of survival and length of stay were not significantly different from those in influenza. Conclusions. RSV can cause severe lower respiratory complications in older adults, resulting in respiratory failure, prolonged hospitalization, and high mortality similar to seasonal influenza. Corticosteroids did not seem to improve outcomes. The unmet need for antiviral therapy and vaccination against RSV in adults should be promptly addressed.
sHER-2 : un nouveau marqueur ? Tse, C.
Médecine nucléaire (Paris),
2010, 2010-1-00, Letnik:
34, Številka:
1
Journal Article, Conference Proceeding
Recenzirano
Dans les cellules tumorales mammaires surexprimant le récepteur transmembranaire HER-2 (ERBB2), la partie extracellulaire de la protéine HER-2 peut être clivée par des métalloprotéases et être ...libérée dans la circulation générale. Le fragment issu de ce clivage est une protéine d’environ 105
kDa appelée p105
HER-2 ou sHER-2 et dosable dans le sérum par une méthode immunochimique. Les valeurs usuelles de la concentration sérique en sHER-2 ont été établies à 15
ng/mL. À l’heure actuelle, le dosage sérique HER-2 n’est préconisé que pour évaluer le statut HER-2 dans le cancer du sein métastatique, lorsque la tumeur n’est pas accessible ou la biopsie métastatique non réalisable. Le seuil requis pour une décision de traitement ciblé sur HER-2 est alors établi à 50
ng/mL. La protéine sHER-2 est un nouveau biomarqueur sérique qui pourrait offrir une valeur prédictive et pronostique supplémentaire à celle apportée par le statut HER-2 de la tumeur. De plus, le dosage de sHER-2 est réalisable à différents temps et permettrait de suivre la réponse au traitement, de prédire la survenue d’une récidive et de suivre en temps réel l’évolution du statut HER-2 en situation métastatique.
The extracellular domain of the HER-2 (ERBB2) oncoprotein (p105
HER-2, ECD HER-2) is shed in the serum and can be detected by immunoassay. The currently approved cutoff for an elevated HER-2 ECD is greater than 15
ng/mL. HER-2 ECD is attractive as a potentially useful serum biomarker. In metastatic breast cancer, serum assay of HER-2 ECD is recommended to assess HER-2 status when unknown in primary tumor or metastatic biopsy is not feasible. In that case, it has been recommended to consider a 50
ng/mL serum HER-2 ECD cutoff as criteria to select patients for HER-2 targeted therapy. It might offer additional prognostic or predictive value compared with HER-2 tumor tissue testing. In addition, it can be measured serially and might be able to monitor treatment response, predict relapse or provide a real-time assessment of HER-2 status at metastatic disease.
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