Correction to Bos, Isabelle; Verhey, Frans R; Ramakers, Inez H G B ...
Alzheimer's research & therapy,
2018, Letnik:
10, Številka:
56
Journal Article
Recenzirano
Odprti dostop
Upon publication of this article 1, it was noticed that there were some inconsistencies in Tables 1, 2 and 3. Some of the superscript letters were incorrectly assigned. Please see below the correct ...tables.
Automated structural magnetic resonance imaging (MRI) processing pipelines and different multivariate techniques are gaining popularity for Alzheimeras disease (AD) research. We used four supervised ...learning methods to classify AD patients and controls (CTL) and to prospectively predict the conversion of mild cognitive impairment (MCI) to AD from baseline MRI data. A total of 345 participants from the AddNeuroMed cohort were included in this study; 116 AD patients, 119 MCI patients and 110 CTL individuals. High resolution sagittal 3D MP-RAGE datasets were acquired and MRI data were processed using FreeSurfer. We explored the classification ability of orthogonal projections to latent structures (OPLS), decision trees (Trees), artificial neural networks (ANN) and support vector machines (SVM). Applying 10-fold cross-validation demonstrated that SVM and OPLS were slightly superior to Trees and ANN, although not statistically significant for distinguishing between AD and CTL. The classification experiments resulted in up to 83% sensitivity and 87% specificity for the best techniques. For the prediction of conversion of MCI patients at baseline to AD at 1-year follow-up, we obtained an accuracy of up to 86%. The value of the multivariate models derived from the classification of AD vs. CTL was shown to be robust and efficient in the identification of MCI converters.
Target symptoms for fluvoxamine in old age depression N Fountoulakis, Magda Tsolaki, Aristides Kazis, Konstantinos
International journal of psychiatry in clinical practice,
2000, Letnik:
4, Številka:
2
Journal Article
Recenzirano
INTRODUCTION: Old age depression is difficult to treat. It is presumed that the underlying biochemical mechanism differs from that of depression of younger age. Clinical manifestations also differ, ...as elderly people manifest more irritability, anxiety, conduct and cognitive disorders than pessimism or guilt. Response to treatment is believed to be poorer than in younger patients. METHOD: Fifty patients, with a mean age of 66.65, suffering from major depression or dysthymia according to DSM-IV criteria, took part in the study. Their mean HDRS score was 16.77. They were prescribed 100 mg of fluvoxamine daily. Half of them returned 3 months later for reassessment by GDS, HDRS, MMSE, CAMCOG and FRSSD. RESULTS: Mean changes in scores were: GDS, -3.14 +/- 10.86; MMSE, -0.96 +/- 3.34; CAMCOG, +1.59 +/- 8.95; and FRSSD -3 +/- 4.96; statistically significant differences were found for GDS and FRSSD scores. All patients manifested residual symptoms. CONCLUSION: Fluvoxamine improved elderly patients suffering from geriatric depression, particularly in respect of depressive thought content (GDS) and impairment in everyday activities (FRSSD). When cognitive impairment due to depression was present, response to treatment was greater. Severely depressed patients showed a greater response to treatment, but also more severe residual symptoms. (Int J Psych Clin Pract 2000; 4:127-134) 3.17 +/- 4.06; HDRS,
Glaucoma, the most common form of which is primary open-angle glaucoma (POAG), is a neurodegenerative disease which is the second most common cause of blindness worldwide. Among the factors that have ...been implicated in the pathophysiology of this disease is infection with Helicobacter pylori. This alleged association has caused a great deal of scientific discussion during the past decade, as the establishment of such a correlation might lead to therapeutic applications for all glaucoma patients. In this review, we assess all relevant major studies and trials in an effort to elucidate the issue.
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