Blazars are the most abundant type of extragalactic gamma-ray source, usually presenting high variability across the electromagnetic spectrum. Their Very High Energy (VHE, above 0.1 TeV) emission has ...been studied in detail using Air Cherenkov Telescopes, with observations biased to flaring periods while their average activity has not been properly characterized. In this work, we report the results of 2090 days of quasi-continuous observations of the blazars 1ES 1215+303 and VER J0521+211, carried out with the High Altitude Water Cherenkov (HAWC) gamma-ray observatory. Fitting a power-law attenuated by photon-photon interaction with the extragalactic background light, we obtained a 6.2 \(\sigma\) level detection for 1ES 1215+303 and a 4.3 \(\sigma\) marginal detection for VER J0521+211. With the inclusion of the HAWC TeV spectrum, we built quasi-simultaneous multiwavelength spectral distributions and fitted a leptonic emission model to the observed data.
We present an update of the survey of Active Galaxies with the High Altitude Water Cherenkov (HAWC) gamma-ray observatory. This work adds 567 days of HAWC data to the previously published survey, ...providing a refined analysis of an updated total exposure of 2090 days. The sample includes 138 nearby AGNs from the 3FHL catalog. We fit a modified power-law to their very high energy spectra, including the exponential attenuation caused by the Extragalactic Background Light. We found four sources with significant detections (above 5\(\sigma\)): the radio galaxy M87 and the BL Lac objects Mkn 421, Mkn 501 and 1ES 1215+303. We also report eight sources with a marginal detection (between 3\(\sigma\) and 5\(\sigma\)) of which seven are classified as BL Lac objects and one as a radio galaxy.
M87 is a giant radio galaxy located in the Virgo Cluster, known to be a very high energy (VHE) gamma-ray source. As radio galaxies are considered the misaligned low-redshift counterparts of blazars, ...they are excellent laboratories for testing AGN emission models. M87 has been detected and monitored by Fermi-LAT and several atmospheric Cherenkov telescopes. Recently, the HAWC Collaboration presented marginal evidence of 4.5 year TeV gamma-ray emission from this object. The HAWC data has the potential to constrain the average VHE emission of sources of complex behavior, like M87, for which the physical origin of the VHE gamma-ray emission is still uncertain. We fitted a lepto-hadronic scenario to the broadband spectral energy distribution of M87 to model its non-flaring VHE emission using HAWC data.
To evaluate sleep disorders and associated factors in patients with rheumatoid-arthritis-associated interstitial lung disease (RA-ILD).
We performed an observational study of 35 patients with RA-ILD ...(cases) and 35 age- and sex-matched RA patients without ILD (controls). We evaluated sleep disorders (Oviedo Sleep Questionnaire), positive psychological factors (resilience using the Wagnild and Young Resilience Scale, emotional intelligence using the 24-item Trait Meta-Mood Scale), anxiety and depression (Hospital Anxiety and Depression Scale), quality of life (36-item short-form survey), and fatigue (Functional Assessment of Chronic Illness Therapy Questionnaire). Other variables studied included the Charlson Comorbidity Index (CCI) and RA activity according to the DAS28-ESR.
Compared to the controls, the cases were characterized by poorer sleep quality with a higher prevalence of insomnia (42% vs. 20%;
= 0.039), greater severity of insomnia (
= 0.001), and lower sleep satisfaction (
= 0.033). They also had poorer resilience and emotional recovery and more severe anxiety and depression. A diagnosis of ILD was the only factor independently associated with the three dimensions of sleep quality. The predictors of poorer sleep satisfaction in patients with RA-ILD were age (β = -0.379), DAS28-ESR (β = -0.331), and usual interstitial pneumonia pattern (β = -0.438). The predictors of insomnia were DAS28-ESR (β = 0.294), resilience (β = -0.352), and CCI (β = 0.377).
RA-ILD is associated with significant sleep disorders. RA-ILD seems to be an independent risk factor for sleep alterations, with a greater impact on insomnia. Age, disease activity, and comorbidity also play a role in sleep disorders in patients with RA-ILD.
