Background: Although there are studies that adequately document the linear correlation between pelvic incidence (PI), sacral slope, lumbar lordosis, and thoracic kyphosis, few have analyzed the ...pelvic-spine correlation including the cervical spine.
Methods: This is a cross-sectional study, wherein the cervical spine was evaluated using radiography and computed tomography (CT) scans, the lumbosacral spine and the pelvis was evaluated using radiography, in adult patients without spinal pathology. Using the Surgimap tool, cervical and spinopelvic parameters were calculated by several investigators. To evaluate the correlation between cervical and spinopelvic parameters, Spearman's coefficient was calculated. To evaluate the concordance correlation of the measured parameters of cervical sagittal alignment on tomography and conventional radiography, Lin's coefficient was calculated and Bland-Altman plots were performed.
Results: A total of 51 healthy adults were included in a follow-up from January 2019 to December 2020. Cervical sagittal alignment and sagittal spinopelvic alignment were assessed using radiography, and a correlation was observed between T1 slope (T1S) and lumbar mismatch (coefficient of 0.28, P = 0.047). Then, cervical sagittal alignment was evaluated using CT and sagittal spinopelvic alignment using radiography, and no correlation was observed between PI and thoracic inlet angle or cervical mismatch with lumbar mismatch.
Conclusion: In asymptomatic patients, in whom cervical sagittal alignment and spinal-pelvic alignment were evaluated, only a positive correlation was found between lumbar mismatch and T1S, which lacks clinical significance. No concordance was identified between lumbar mismatch and cervical mismatch. Therefore, it is inferred that there is an independence between the sagittal spine-pelvic alignment with respect to the sagittal cervical alignment.
The flat wasp family Bethylidae Haliday lacks global scale literature on their alpha taxonomy. The only world revision for the family was by Kieffer in 1914 and is fully out of date and somewhat ...useless; the only catalog for the family was made by Gordh Móczár in 1990 and does not include hundreds of changes made since then; and the most recent world genera keys were proposed by Terayama in 2003, but do not reflect the current knowledge we have for the family. Given this scenario, we present a global guide of Bethylidae with diagnoses, taxonomic evaluation, keys, and a checklist of all their extant genera and subfamilies. We visited the main collections around the world, analyzed about 2,000 holotypes, and examined at least 400,000 specimens. To eliminate homonymies, we add the prefix "neo" to the original specific epithet when possible. The family is now composed by 2,920 species allocated in 96 genera distributed in eight subfamilies: Bethylinae, Pristocerinae, Epyrinae, Mesitiinae, Scleroderminae, Lancepyrinae, Holopsenellinae and Protopristocerinae. The latter three are extinct. One new family-group synonym is proposed: Fushunochrysidae Hong syn. nov. of Bethylidae. Two incertae sedis genera are allocated into Bethylinae: Cretobethylellus Rasnytsyn and Omaloderus Walker. One new genus-group synonym is revalidated: Pristepyris Kieffer stat. rev. from Acrepyris Kieffer. Sixteen new genus-group synonyms are proposed: Fushunochrysites Hong syn. nov. and Sinibethylus Hong syn. nov. of Eupsenella Westwood; Messoria Meunier syn. nov. of Goniozus Förster; Acrepyris Kieffer syn. nov. of Pristepyris Kieffer; Apristocera Kieffer syn. nov. and Parapristocera Brues syn. nov. of Pristocera Klug; Usakosia Kieffer syn. nov. of Prosapenesia Kieffer; Isobrachium Förster syn. nov., Leptepyris Kieffer syn. nov., Neodisepyris Kurian syn. nov., Rhabdepyris Kieffer syn. nov. of Epyris Westwood; Codorcas Nagy syn. nov., Hamusmus Argaman syn. nov. and Ukayakos Argaman syn. nov. of Heterocoelia Dahlbom; Domonkos Argaman syn. nov. of Incertosulcus Móczár; Ateleopterus Förster syn. nov. of Sclerodermus Latreille. One new genus-group synonym is revalidated: Topcobius Nagy syn. rev. of Sulcomesitius Móczár. One new genus-group revalidation is proposed: Incertosulcus Móczár stat. rev. from Anaylax Móczár. The following species-group nomenclatural acts are established: 153 new or revalidated combinations, 16 new names to avoid secondary homonyms, 11 species with revalidated status, and one synonym. Keys to the subfamilies and genera are provided. The text is supported by 599 illustrations organized onto 92 plates.
La Porción Surponiente del Estado de México (PSEM) se ubica en la Zona de Transición Mexicana de Montaña. Las comunidades forestales que predominan en este territorio son bosques de pino (Pinus ...spp.), encino (Quercus spp.), mixtos (Pinus spp. - Quercus spp. y Quercus spp. - Pinus spp.), mesófilo de montaña y tropical caducifolio, los cuales están siendo modificados por la influencia de procesos antropogénicos. Este estudio presenta el análisis de los cambios de cobertura y uso del suelo ocurridos entre 1989 y 2009 en la PSEM, a través de la interpretación de imágenes de satélite (Landsat TM), que en complemento con la aplicación del algoritmo máxima verosimilitud permitieron la construcción de mapas temáticos de uso de suelo y vegetación, los cuales fueron evaluados para conocer su confiabilidad temática. A partir de la sobreposición de estos mapas se elaboró una matriz de cambios que comprende la superficie de las coberturas y usos del suelo para cada año y con base en esta se determinaron las tasas de cambio. Los resultados obtenidos demuestran que la cobertura del bosque disminuyó considerablemente, es decir, se eliminaron 19 262 ha, las cuales fueron ocupadas por las categorías cuerpos de agua (105 ha), agropecuario (19 113 ha), asentamientos humanos (39 ha) y agricultura tecnificada controlada (5 ha). La superficie deforestada es resultado del establecimiento y la práctica de actividades relacionadas con la agricultura y ganadería.
Resistive switching, a phenomenon in which the resistance of a device can be modified by applying an electric field
, is at the core of emerging technologies such as neuromorphic computing and ...resistive memories
. Among the different types of resistive switching, threshold firing
is one of the most promising, as it may enable the implementation of artificial spiking neurons
. Threshold firing is observed in Mott insulators featuring an insulator-to-metal transition
, which can be triggered by applying an external voltage: the material becomes conducting ('fires') if a threshold voltage is exceeded
. The dynamics of this induced transition have been thoroughly studied, and its underlying mechanism and characteristic time are well documented
. By contrast, there is little knowledge regarding the opposite transition: the process by which the system returns to the insulating state after the voltage is removed. Here we show that Mott nanodevices retain a memory of previous resistive switching events long after the insulating resistance has recovered. We demonstrate that, although the device returns to its insulating state within 50 to 150 nanoseconds, it is possible to re-trigger the insulator-to-metal transition by using subthreshold voltages for a much longer time (up to several milliseconds). We find that the intrinsic metastability of first-order phase transitions is the origin of this phenomenon, and so it is potentially present in all Mott systems. This effect constitutes a new type of volatile memory in Mott-based devices, with potential applications in resistive memories, solid-state frequency discriminators and neuromorphic circuits.
Background
Splenectomy is a therapy for patients with treatment‐refractory autoimmune cytopenias. Antiphospholipid antibodies (aPL) can be identified in 25%–85% of these patients. In this study, we ...sought to identify whether the presence of aPL was associated with worse outcomes in autoimmune cytopenia's patients who had undergone splenectomy.
Methods
We conducted a retrospective cohort study of patients who underwent splenectomy from 2000 to 2018. We describe clinical characteristics and outcomes in patients with autoimmune cytopenia's diagnosis with positive determinations of aPL. Additionally, we performed a case–control sub‐analysis 1:1 of the cases with autoimmune cytopenia's matched control patients with negative aPL determination.
Results
A splenectomy was performed in 707 patients, of which we included 34 for the analysis. The median age at the time of splenectomy was 37 years (range 19–61), 53% corresponded to immune thrombocytopenia (ITP) and 47% to autoimmune hemolytic anemia (AIHA). Compared with controls (n = 34), patients had more treatment lines in addition to steroids (p = .02). There were no differences in complete response rate, 65% in cases and 80% in controls (p = .17). However, there was numerically a higher incidence of early infections (21% of cases vs. 3% controls, p = .05). During the entire follow‐up, 15% of aPL patients compared with 9% of control patients had a thrombotic event (p = .70).
Discussion
Splenectomy for treatment‐refractory autoimmune cytopenia's patients with persistent aPL is an effective treatment despite some safety concerns related to early infections. These results suggest that the presence of aPL should not impact the decision to undergo splenectomy.
Four dengue virus serotypes (DENV1-4) circulate globally, causing more human illness than any other arthropod-borne virus. Dengue can present as a range of clinical manifestations from ...undifferentiated fever to Dengue Fever to severe, life-threatening syndromes. However, most DENV infections are inapparent. Yet, little is known about determinants of inapparent versus symptomatic DENV infection outcome. Here, we analyzed over 2,000 DENV infections from 2004 to 2011 in a prospective pediatric cohort study in Managua, Nicaragua. Symptomatic cases were captured at the study health center, and paired healthy annual samples were examined on a yearly basis using serological methods to identify inapparent DENV infections. Overall, inapparent and symptomatic DENV infections were equally distributed by sex. The mean age of infection was 1.2 years higher for symptomatic DENV infections as compared to inapparent infections. Although inapparent versus symptomatic outcome did not differ by infection number (first, second or third/post-second DENV infections), substantial variation in the proportion of symptomatic DENV infections among all DENV infections was observed across study years. In participants with repeat DENV infections, the time interval between a first inapparent DENV infection and a second inapparent infection was significantly shorter than the interval between a first inapparent and a second symptomatic infection. This difference was not observed in subsequent infections. This result was confirmed using two different serological techniques that measure total anti-DENV antibodies and serotype-specific neutralizing antibodies, respectively. Taken together, these findings show that, in this study, age, study year and time interval between consecutive DENV infections influence inapparent versus symptomatic infection outcome, while sex and infection number had no significant effect. Moreover, these results suggest that the window of cross-protection induced by a first infection with DENV against a second symptomatic infection is approximately 2 years. These findings are important for modeling dengue epidemics and development of vaccines.
•Conflict may damage forests or help preserving them by dissuading economic activity.•We use satellite data to study the effect of Colombia’s peace deal on forest cover.•Former conflict areas ...differentially lose forest cover after the FARC’s ceasefire.•Loss in forest cover is offset by state capacity, but exacerbated by cattle ranching.•Findings highlight the importance of complementing peacemaking with state building.
Armed conflict can endanger natural resources through several channels such as direct predation from fighting groups, but it may also help preserve ecosystems by dissuading extractive economic activities through the fear of extortion. The effect of conflict on deforestation is thus an empirical question. This paper studies the effect on forest cover of Colombia’s recent peace negotiation between the government and the FARC insurgency. Using yearly deforestation data from satellite images and a difference-in-differences identification strategy, we show that areas controlled by FARC prior to the declaration of a permanent ceasefire experienced a differential increase in deforestation after the start of the ceasefire. The deforestation effect of peace is attenuated in municipalities with higher state presence and judicial capacity, and is exacerbated by land intensive economic activities. Our results highlight the importance of complementing peacemaking milestones with state building efforts to avoid environmental damage.
The concept of rule-governed behavior (RGB) has been used in the behavior-analytic literature as a way to analyze complex human behavior, including thinking and problem-solving. Relational frame ...theory suggests the existence of two main functional types of RGB termed pliance and tracking. In this paper, we describe the development of the Generalized Tracking Questionnaire (GTQ) and the preliminary evaluation of its psychometric properties and validity through three studies, with a total of 1155 participants. In Study 1, a pool of items describing the main characteristics of generalized tracking was designed and evaluated by experts on the RFT account of RGB. The resulting 11 items were administered to 460 undergraduates to examine the understandability and psychometric quality of the items. The exploratory factor analysis indicated that the GTQ can be seen as a unidimensional scale, with all items exhibiting high factor loadings and corrected item-total correlations. In Study 2, the GTQ was administered online to a sample of 464 non-clinical participants and a clinical sample of 125 participants. The one-factor model of the GTQ obtained a good fit in the conducted confirmatory factor analysis. The GTQ showed measurement invariance across gender and clinical and nonclinical participants. It also obtained excellent internal consistency and correlated in theoretically coherent ways with other constructs. In Study 3, the GTQ and a neuropsychological battery of executive functions were administered to 105 participants. The GTQ showed statistically significant, medium-size correlations with working memory tests, verbal fluency, planning, and behavioral inhibition. In conclusion, the GTQ seems to be a promising measure to advance in the empirical analysis of functional classes of RGB.
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