T-cell lymphoma was diagnosed, and the patient ultimately died despite chemotherapy. ...an extremely high copy number (5 x 109 copies/mL) of Torque teno virus (TTV) DNA was detected in the patient's ...plasma, corresponding to the highest TTV titer measured in our experience (plasma samples of 33 healthy adult controls all harbored <105 copies/mL of TTV DNA). A unique feature of T cells in the Elektra mouse is premature entry into cell-cycle S-phase on activation.8 Similarly, 18 hours after in vitro activation with phorbol 12-myristate 13-acetate/ionomycin, more than 75% of the patient's T cells versus less than 25% of the control's T lymphocytes displayed hyperdiploid DNA content, indicative of increased S-phase transition (Fig 2, D). ...phosphorylation of the retinoblastoma protein, a major orchestrator of S-phase entry, was augmented in the patient's T cells (Fig 2, E).
Abstract
Pleural effusion (PE), a complication of community-acquired pneumonia (CAP), is usually attributed to a bacterial infection. Nonetheless, viral infections have not been investigated ...routinely. We searched for bacterial and viral infections among 277 children hospitalized with CAP. Among these children 206 (74%) had radiographic confirmation, of whom 25 (12%) had PE. The aetiology was established in 18 (72%) PE cases: bacterial (n = 5; 28%), viral (n = 9; 50%), and viral-bacterial (n = 4; 22%) infections were found. Infection by rhinovirus (n = 3), enterovirus, Streptococcus pneumoniae (n = 2 each), Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, influenza A virus, and respiratory syncytial virus (RSV) (n = 1 each) were detected as probable sole infections. Parainfluenza virus 1/3 + influenza A virus and RSV + influenza A virus (n = 1 each) were identified as mixed viral-viral infections. Probable viral non-bacterial infection was identified in a third of the cases with CAP and PE. It is advisable to investigate viral as well as bacterial infections among children with CAP and PE.
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