Contrast-induced neurotoxicity (CIN) is an adverse reaction to contrast agents which can occur in the context of diagnostic and therapeutic neurological endovascular procedures. Our goal was to ...conduct a systematic review of patients reported in the literature diagnosed with CIN after neurological endovascular procedures. A systematic search of EMBASE and MEDLINE databases was conducted. Inclusion criteria were age ≥ 18 years; neurological endovascular procedure performed ≤ 24 h before ictus; new manifestations compatible with encephalic dysfunction; imaging performed < 7 days after ictus; exclusion of other causes and manifestations attributed to pre-existing conditions. Forty-eight patients were included, of which 60.4% were female and 60.4% had arterial hypertension; median age was 63 years. The most frequent procedure was diagnostic cerebral angiography (
n
= 24, 50.0%) and non-ionic contrast agents were more frequently used (
n
= 40, 83.3%). Twenty-six patients (54.2%) developed clinical manifestations compatible with CIN during or immediately after the procedure, and the most frequent manifestations were encephalopathy, cortical blindness and motor deficit. The most frequent imaging findings were cortical contrast enhancement on CT (
n
= 23/42), and cortical sulci effacement (
n
= 18/48). Most patients presented complete clinical recovery (89.6%) at a median time of 3 days. Among patients with neuroimaging changes who underwent follow-up, complete regression of the abnormalities was shown in 81.5% at a median time of 5 days. CIN is a rare adverse reaction in the context of neurological endovascular procedures. Recognition of clinical manifestations and typical imaging abnormalities, while excluding other causes, is essential for diagnosis.
This paper focuses on the analysis of the different motifs that shape the linguistic expression of shame and guilt in Old English. Through the fine-grained analysis of the whole set of shame and ...guilt expressions recorded in a corpus of Old English texts, a network of literal and figurative conceptualizations for each emotion is proposed. On the basis of these expressions, I argue here that body-related expressions (either metonymic or metaphoric) occupy a very secondary role in the Anglo-Saxon imagery of shame and guilt. In clear contrast with this view of shame and guilt as instruments of social control, the Christianization of England implied the spread of new shame-related values and the growing use of a new set of embodied conceptualizations for the two emotions under scrutiny here, most of which have become common figurative expressions of shame and guilt in later varieties of English. The new expressions (e.g. SHAME IS REDNESS IN THE FACE and SHAME IS SOMETHING COVERING A PERSON) illustrate the shift towards a progressive embodiment of the new emotional standards brought by Christianization. According to these standards, rather than an external judgment or reproach, shame and guilt involve a negative evaluation of oneself. Furthermore, I argue here that these onomasiological changes are informing us on the lexical choices of Old English speakers and on the sociolinguistic factors that conditioned the development of new emotional styles (i.e., the different ways feelings were expressed and, surely, felt) in Anglo-Saxon England.
For patients with metastatic castration-resistant prostate cancer (mCRPC) progressing after an androgen receptor axis–targeted therapy and docetaxel, poly (ADP-ribose) polymerase (PARP) inhibitors ...and chemotherapy with cabazitaxel have shown promise. We address the trials for the two approaches and consider possible sequencing of these drugs. We suggest that only patients with a BRCA2 mutation should receive a PARP inhibitor, and docetaxel or cabazitaxel should be favored in the absence of BRCA2 alterations, provided the patient is naïve to these drugs.
This study reports the identification of a new gene conferring resistance to the Ug99 lineage of races of Puccinia graminis f. sp. tritici in wheat (Triticum aestivum L.). Because the virulent races ...of stem rust pathogen continue to pose a serious threat in global wheat production, identification and molecular characterization of new resistance genes remains of utmost important to enhance resistance diversity and durability in wheat germplasm. Advanced wheat breeding line 'ND643/2*Weebill1' carries a stem rust resistance gene, temporarily designated as SrND643, effective against the Ug99 group of P. graminis f. sp. tritici races at both seedling and adult growth stages. This study was conducted to map the chromosomal location of SrND643 and identify closely linked molecular markers to allow its selection in breeding populations. In total, 123 recombinant inbred lines, developed by crossing ND643/2*Weebill1 with susceptible line 'Cacuke', were evaluated for stem rust response in field nurseries at Njoro, Kenya, during two growing seasons in 2010, and were genotyped with DNA markers, including Diversity Arrays Technology, simple sequence repeats (SSR), and single-nucleotide polymorphisms. Linkage mapping tagged SrND643 at the distal end of chromosome 4AL, showing close association with SSR markers Xgwm350 (0.5 centimorgans cM), Xwmc219 (4.1 cM), and Xwmc776 (2.9 cM). The race specificity of SrND643 is different from that of Sr7a and Sr7b, indicating that the resistance is conferred by a gene at a new locus or by a new allele of Sr7. The flanking markers Xgwm350 and Xwmc219 were predictive of the presence of SrND643 in advanced germplasm, thus validating the map location and their use in marker-assisted selection.
Objective. To determine how often patients with musculoskeletal (MSK) complaints prescribed a non-steroidal anti-inflammatory drug (NSAID) subsequently consult their general practitioner (GP) with a ...non-serious adverse drug reaction (ADR). Design. Cohort study. Setting. A healthcare database containing the electronic GP medical records of over 1.5 million patients throughout the Netherlands. Patients. A total of 16 626 adult patients with MSK complaints prescribed an NSAID. Main outcome measures. The patients' medical records were manually assessed for the duration of NSAID use for a maximum of two months, and consultations for complaints predefined as potential ADRs were identified. Subsequently, the likelihood of an association with the NSAID use was assessed and these potential ADRs were categorized as likely, possible, or unlikely ADRs. Results. In total, 961 patients (6%) consulted their GP with 1227 non-serious potential ADRs. In 174 patients (1%) at least one of these was categorized as a likely ADR, and in a further 408 patients (2.5%) at least one was categorized as a possible ADR. Dyspepsia was the most frequent likely ADR, followed by diarrhoea and dyspnoea (respectively 34%, 8%, and 8% of all likely ADRs). Conclusion. Of the patients with MSK complaints prescribed an NSAID, almost one in 30 patients re-consulted their GP with a complaint likely or possibly associated with the use of this drug. The burden of such consultations for non-serious ADRs should be taken into account by GPs when deciding whether treatment with an NSAID is appropriate.
- The trace spaces H1/2 and H1/2 00 play a key role in the FETI and mortar families of domain decomposition methods. However, a direct numerical evaluation of these norms is usually avoided. On the ...other hand, and for stability issues, the subspace of functions for which their jumps across the interfaces of neighbouring subdomains belong to these trace spaces yields a more suitable framework than the standard broken Sobolev space. Finally, the nullity of these jumps is usually imposed via Lagrange multipliers and using the pairing of the trace spaces with their duals. A direct computation of these pairings can be performed using the Riesz-canonical isometry. In this work we consider all these ingredients and introduce a domain decomposition method that falls into the FETI-DP mortar family. The application is to the incompressible Stokes problem and we see that continuous bounds are replicated at the discrete level. As a consequence, no stabilization is required. Some numerical tests are finally presented.
Lithium cobalt oxide (LiCoO2) is one of the most relevant components in lithium-ion batteries. The array of sought-after features of LiCoO2 depends on its synthesis method. In this work we ...synthesized and characterized a nanocrystalline LiCoO2 oxide obtained with a wet chemistry synthesis method. The oxide obtained was a homogeneous powder in the nanometric range (5-8 nm) and exhibited a series of improved properties. Characterization by FTIR and UV-Vis techniques led to identifying citrate species as main products in the first step of the synthesis process. X-ray diffraction (XRD), Raman, and transmission electron microscopy (TEM) characterizations led to identifying a pure crystalline phase of the synthesized LiCoO2 oxide. Steady state electrical characterization and solid-state impedance spectroscopy determined the high conductance of the synthesized oxide. All these features are desirable in the design of cathodes for lithium ion batteries.
Bilateral agenesis or hypoplasia of the internal carotid artery (ICA) is a rare anomaly of embryogenesis and the simultaneous occurrence of aneurysms is higher than in the general population. We ...report a 74-year-old patient presenting a spontaneous subarachnoid haemorrhage whose CT-angiography showed a basilar aneurysm and bilateral absence of the internal carotid arteries. Also bilateral hypoplastic carotid canal in the skull base was identified. Digital subtraction angiography after surgical clipping of the aneurysm confirmed the absence of the internal carotid arteries; anterior circulation was totally supplied by enlarged posterior communicating arteries.
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