Chronic hepatitis C virus (HCV) infection is a worldwide public health problem with a global prevalence of 2-3%. It is believed that about 170 million people are currently infected (about 3% of the ...world's population), and a further 3-4 million are infected each year. HCV is the main reason for liver transplantation in the developed world, and the main cause of liver-related morbidity and mortality in a number of countries, including Italy. It is not only a frequent cause of chronic liver diseases such as hepatitis, cirrhosis and hepatocellular carcinoma, but is also involved in the pathogenesis of various autoimmune and rheumatic disorders (arthritis, vasculitis, sicca syndrome, porphyria cutanea tarda, lichen planus, nephropathies, thyroid diseases, and lung fibrosis), as well as in the development of B-cell lymphoproliferative diseases. Furthermore, patients suffering from C hepatitis tend to produce rheumatoid factor, cryoglobulins and a large series of autoantibodies (ANA, anti-SSA/SSB, SAM, ATG, aCL). The use of glucocorticoids or immuno-suppressant agents in HCV infected individuals, which are needed to treat autoimmune and rheumatic disorders, leads to a risk of worsening the clinical outcome of HCV. Under these conditions, the viral infection often needs to be treated with antiviral agents, mainly pegylated interferon combined with ribavirin. However, cyclosporine A seems to be safe and effective in patients with autoimmune disease (AD) and concomitant chronic HCV infection as is documented by the reduction in viremia and transaminases, particularly in patients with high baseline levels. Finally, HCV is the main trigger of mixed cryoglobulinemia. An attempt at viral eradication is therefore indicated in most patients, and is particularly effective in the case of mild or moderate manifestations. In severe cases, rituximab is an apparently safe and effective alternative to conventional immunosuppression and, specifically, it controls B-cell proliferation.
Utilizing spectroscopic observations taken for the VIMOS Ultra-Deep Survey (VUDS), new observations from Keck/DEIMOS, and publicly available observations of large samples of star-forming galaxies, we ...report here on the relationship between the star-formation rate (SFR) and the local environment (
δ
gal
) of galaxies in the early universe (2 <
z
< 5). Unlike what is observed at lower redshifts (
z
≲ 2), we observe a definite, nearly monotonic increase in the average SFR with increasing galaxy overdensity over more than an order of magnitude in
δ
gal
. The robustness of this trend is quantified by accounting for both uncertainties in our measurements and galaxy populations that are either underrepresented or not present in our sample (e.g., extremely dusty star-forming and quiescent galaxies), and we find that the trend remains significant under all circumstances. This trend appears to be primarily driven by the fractional increase of galaxies in high-density environments that are more massive in their stellar content and are forming stars at a higher rate than their less massive counterparts. We find that, even after stellar mass effects are accounted for, there remains a weak but significant SFR–
δ
gal
trend in our sample implying that additional environmentally related processes are helping to drive this trend. We also find clear evidence that the average SFR of galaxies in the densest environments increases with increasing redshift. These results lend themselves to a picture in which massive gas-rich galaxies coalesce into proto-cluster environments at
z
≳ 3, interact with other galaxies or with a forming large-scale medium, subsequently using or losing most of their gas in the process, and begin to seed the nascent red sequence that is present in clusters at slightly lower redshifts.
Aims. The chemical evolution of galaxies on a cosmological timescale is still a matter of debate despite the increasing number of available data provided by spectroscopic surveys of star-forming ...galaxies at different redshifts. The fundamental relations involving metallicity, such as the mass − metallicity relation (MZR) or the fundamental metallicity relation, give controversial results about the reality of evolution of the chemical content of galaxies at a given stellar mass. In this work we shed some light on this issue using the completeness reached by the 20 k bright sample of the zCOSMOS survey and using for the first time the nitrogen-to-oxygen ratio (N/O) as a tracer of the gas phase chemical evolution of galaxies that is independent of the star formation rate. Methods. Emission-line galaxies both in the SDSS and 20 k zCOSMOS bright survey were used to study the evolution from the local Universe of the MZR up to a redshift of ~1.32, and the relation between stellar mass and N/O (MNOR) up to a redshift of ~0.42 using the N2S2 parameter. All the physical properties derived from stellar continuum and gas emission-lines, including stellar mass, star formation rates, metallicity and N/O, were calculated in a self-consistent way over the full redshift range. Results. We confirm the trend to find lower metallicities in galaxies of a given stellar mass in a younger Universe. This trend is even observed when taking possible effects into account that are due to the observed larger median star formation rates for galaxies at higher redshifts. We also find a significant evolution of the MNOR up to z ~ 0.4. Taking the slope of the O/H vs. N/O relation into account for the secondary-nitrogen production regime, the observed evolution of the MNOR is consistent with the trends found for both the MZR and its equivalent relation using new expressions to reduce its dependence on star formation rate.
We present here a survey of high-ionization absorption lines in the afterglow spectra of long-duration gamma-ray bursts (GRBs) obtained with the VLT/X-shooter spectrograph. Our main goal is to ...investigate the circumburst medium in the natal regions of GRBs. Our primary focus is on the N vλλ 1238, 1242 line transitions, but we also discuss other high-ionization lines such as O vi, C iv, and Si iv. We find no correlation between the column density of N v and the neutral gas properties such as metallicity, H i column density, and dust depletion; however, the relative velocity of N v, typically a blueshift with respect to the neutral gas, is found to be correlated with the column density of H i. This may be explained if the N v gas is part of an H ii region hosting the GRB, where the region’s expansion is confined by dense, neutral gas in the GRB’s host galaxy. We find tentative evidence (at 2σ significance) that the X-ray derived column density, N_H, X, may be correlated with the column density of N v, which would indicate that both measurements are sensitive to the column density of the gas located in the vicinity of the GRB. We investigate the scenario where N v (and also O vi) is produced by recombination after the corresponding atoms have been stripped entirely of their electrons by the initial prompt emission, in contrast to previous models where highly ionized gas is produced by photoionization from the GRB afterglow.
Aims. We present and release photometric redshifts for a uniquely large and deep sample of 522286 objects with $i'_{\rm AB}\le 25$ in the Canada-France Hawaii Telescope Legacy Survey (CFHTLS) “Deep ...Survey” fields D1, D2, D3, and D4, which cover a total effective area of 3.2 $\deg^2$. Methods. We use 3241 spectroscopic redshifts with $0 \leq z \leq 5$ from the VIMOS VLT Deep Survey (VVDS) as a calibration and training set to derive these photometric redshifts. Using the “Le Phare” photometric redshift code, we developed a robust calibration method based on an iterative zero-point refinement combined with a template optimisation procedure and the application of a Bayesian approach. This method removes systematic trends in the photometric redshifts and significantly reduces the fraction of catastrophic errors (by a factor of 2), a significant improvement over traditional methods. We use our unique spectroscopic sample to present a detailed assessment of the robustness of the photometric redshift sample. Results. For a sample selected at $i'_{\rm AB}\le 24$, we reach a redshift accuracy of $\sigma_{\Delta z/(1+z)}=0.029$ with $\eta=3.8\%$ of catastrophic errors (η is defined strictly as those objects with $|\Delta z|/(1+z) > 0.15$). The reliability of our photometric redshifts decreases for faint objects: we find $\sigma_{\Delta z/(1+z)}=0.025, 0.034$ and $\eta=1.9\%, 5.5\%$ for samples selected at $i'_{\rm AB}=17.5$–22.5 and 22.5–24 respectively. We find that the photometric redshifts of starburst galaxies are less reliable: although these galaxies represent only 22% of the spectroscopic sample, they are responsible for 50% of the catastrophic errors. An analysis as a function of redshift demonstrates that our photometric redshifts work best in the redshift range $0.2\le z \le 1.5$. We find an excellent agreement between the photometric and the VVDS spectroscopic redshift distributions at $i'_{\rm AB}\le 24$. Finally, we compare the redshift distributions of i' selected galaxies on the four CFHTLS deep fields, showing that cosmic variance is still present on fields of 0.7–0.9 deg2. These photometric redshifts are made publicly available at http://terapix.iap.fr (complete ascii catalogues) and http://cencos.oamp.fr/cencos/CFHTLS/ (searchable database interface).
We explore the role of environment in the evolution of galaxies over 0.1 < z < 0.7 using the final zCOSMOS-bright data set. Using the red fraction of galaxies as a proxy for the quenched population, ...we find that the fraction of red galaxies increases with the environmental overdensity δ and with the stellar mass M
*, consistent with previous works. As at lower redshift, the red fraction appears to be separable in mass and environment, suggesting the action of two processes: mass m(M
*) and environmental ρ(δ) quenching. The parameters describing these appear to be essentially the same at z ∼ 0.7 as locally. We explore the relation between red fraction, mass and environment also for the central and satellite galaxies separately, paying close attention to the effects of impurities in the central-satellite classification and using carefully constructed samples well matched in stellar mass. There is little evidence for a dependence of the red fraction of centrals on overdensity. Satellites are consistently redder at all overdensities, and the satellite quenching efficiency, sat(δ, M
*), increases with overdensity at 0.1 < z < 0.4. This is less marked at higher redshift, but both are nevertheless consistent with the equivalent local measurements. At a given stellar mass, the fraction of galaxies that are satellites, f
sat(δ, M
*), also increases with overdensity. The obtained ρ(δ)/f
sat(δ, M
*) agrees well with sat(δ, M
*), demonstrating that the environmental quenching in the overall population is consistent with being entirely produced by a satellite quenching process at least up to z = 0.7. However, despite the unprecedented size of our high-redshift samples, the associated statistical uncertainties are still significant and our statements should be understood as approximations to physical reality, rather than physically exact formulae.
We present the Galaxy Stellar Mass Function (GSMF) up to z~1 from the zCOSMOS-bright 10k spectroscopic sample. We investigate the total MF and the contribution of ETGs and LTGs, defined by broad-band ...SED, morphology, spectral properties or star formation activities. We unveil a galaxy bimodality in the global MF, at least up to the z~0.55, better represented by 2 Schechter functions dominated by ETGs and LTGs, respectively. For the global population we confirm that low-mass galaxies number density increases later and faster than for massive galaxies. We find that the MF evolution at intermediate-low Mstar (logM<10.6) is mostly explained by a growth in stellar mass driven by smooth and decreasing SFHs. The low/negligible evolution at higher Mstar sets a limit of 30-15%, decreasing with redshift, to the fraction of major merging. We find that ETGs increase in number density with cosmic time faster for decreasing Mstar, with a median "building redshift" increasing with mass, in contrast with hierarchical model predictions. For LTGs we find that the number density of blue or spiral galaxies remains almost constant with cosmic time from z~1. Instead, the most extreme population of active star forming galaxies is rapidly decreasing in number density. We suggest, firstly, a transformation from blue active spiral galaxies of intermediate mass into blue quiescent and successively (1-2 Gyr after) into red passive types. The complete morphological transformation into red spheroidal galaxies, required longer time-scales or follows after 1-2 Gyr. A continuous replacement of blue galaxies is expected by low-mass active spirals growing in stellar mass. We estimate that on average ~25% of blue galaxies is transforming into red per Gyr for logM<11. We expect a negligible evolution of the global Galaxy Baryonic MF. ABRIDGED
Abstract
We report the detection of the CO(3-2) emission line from the host galaxy of gamma-ray burst (GRB) 080207 at z = 2.086. This is the first detection of molecular gas in emission from a GRB ...host galaxy beyond redshift 1. We find this galaxy to be rich in molecular gas with a mass of $1.1 \times 10^{11}\,\rm M_{{\odot }}$ assuming αCO = 4.36 $\rm M_{{\odot }}\,(\rm K\,km\,s^{-1}\,pc^2)^{-1}$. The molecular gas mass fraction of the galaxy is ∼0.5, typical of star-forming galaxies (SFGs) with similar stellar masses and redshifts. With an $\rm SFR_{FIR}$ of 260 $\rm M_{{\odot }}\,yr^{-1}$, we measure a molecular gas depletion time-scale of 0.43 Gyr, near the peak of the depletion time-scale distribution of SFGs at similar redshifts. Our findings are therefore in contradiction with the proposed molecular gas deficiency in GRB host galaxies. We argue that the reported molecular gas deficiency for GRB hosts could be the artefact of improper comparisons or neglecting the effect of the typical low metallicities of GRB hosts on the CO-to-molecular-gas conversion factor. We also compare the kinematics of the CO(3-2) emission line to that of the H α emission line from the host galaxy. We find the H α emission to have contributions from two separate components, a narrow and a broad one. The narrow component matches the CO emission well in velocity space. The broad component, with a full width at half-maximum of ∼1100 $\rm km\,s^{-1}$, is separated by +390 $\rm km\,s^{-1}$ in velocity space from the narrow component. We speculate this broad component to be associated with a powerful outflow in the host galaxy or in an interacting system.
Observations of distant supernovae indicate that the Universe is now in a phase of accelerated expansion the physical cause of which is a mystery. Formally, this requires the inclusion of a term ...acting as a negative pressure in the equations of cosmic expansion, accounting for about 75 per cent of the total energy density in the Universe. The simplest option for this 'dark energy' corresponds to a 'cosmological constant', perhaps related to the quantum vacuum energy. Physically viable alternatives invoke either the presence of a scalar field with an evolving equation of state, or extensions of general relativity involving higher-order curvature terms or extra dimensions. Although they produce similar expansion rates, different models predict measurable differences in the growth rate of large-scale structure with cosmic time. A fingerprint of this growth is provided by coherent galaxy motions, which introduce a radial anisotropy in the clustering pattern reconstructed by galaxy redshift surveys. Here we report a measurement of this effect at a redshift of 0.8. Using a new survey of more than 10,000 faint galaxies, we measure the anisotropy parameter = 0.70 ± 0.26, which corresponds to a growth rate of structure at that time of f = 0.91 ± 0.36. This is consistent with the standard cosmological-constant model with low matter density and flat geometry, although the error bars are still too large to distinguish among alternative origins for the accelerated expansion. The correct origin could be determined with a further factor-of-ten increase in the sampled volume at similar redshift.
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