The association of type 2 diabetes mellitus (T2DM) with the
and
genes in the Russian population has not been well studied. In this study, we analysed the population frequencies of polymorphic markers ...of these genes.
The study included 862 patients with T2DM and 443 control subjects of Russian origin. All subjects were genotyped for 10 single nucleotide polymorphisms (SNPs) of the genes using real-time PCR (TaqMan assays). HOMA-IR and HOMA-
were used to measure insulin resistance and
-cell secretory function, respectively.
The analysis of the frequency distribution of polymorphic markers for genes
and
showed statistically significant associations with T2DM in the Russian population. The association between the
gene and T2DM was not statistically significant. The polymorphic markers
of the
gene,
of the
gene,
of the
gene and
,
and
of the
gene showed a significant association with impaired glucose metabolism or impaired
-cell function.
In the Russian population, genes, which affect insulin synthesis and secretion in the
-cells of the pancreas, play a central role in the development of T2DM.
According to the "Federal Law on the Fundamentals of Protection of the Public Health", medical care for patients should be provided in accordance with National Russian guidelines for the relevant ...nosology, which are based on the principles of evidence-based medicine. The article presents an analysis of the compliance with the completeness of implementation of National Russian guidelines in the treatment of patients with type 2 diabetes mellitus (DM 2) in real clinical practice. The analysis of the actual state of management of DM 2 patients was carried out from the Federal Register of diabetes as of 01.01.2023. Incomplete compliance with the guidelines on the frequency of measuring glycated hemoglobin, the rate of intensification of hypoglycemic therapy, and the appointment of new classes of hypoglycemic drugs was established. Possible reasons for the identified discrepancies between real practice and guidelines requirements are discussed, as well as possible measures to overcome these discrepancies.
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