The Hijacking of the Bioeconomy Vivien, F.-D.; Nieddu, M.; Befort, N. ...
Ecological economics,
05/2019, Letnik:
159
Journal Article
Recenzirano
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Georgescu-Roegen used the term bioeconomy to refer to a radical ecological perspective on economics he developed in the 1970s and 1980s. In recent years, it has also become a buzzword used by public ...institutions to announce and describe a supposed current economic and ecological transition. We see in this use an attempt of semantic hijacking of the original term. To support this claim we analyze three different interpretations of the term bioeconomy, presenting each of them as narratives combining distinct visions of future economic development, technical trajectories and imaginaries associated with a particular relationship to nature. Finally, we discuss these narratives in relation to the endorsement they receive by different stakeholders.
•Reviews the bioeconomy as defined by N. Georgescu-Roegen in order to discuss the development of the bioeconomy.•Adopts a narrative-based approach in order to identify main narratives as ideal-types.•Compares three main narratives of the bioeconomy: sustainability-oriented, science-oriented, and biomass-oriented.•Science and biomass-oriented narratives are dominating and trying to hijack Georgescu-Roegen’ bioeconomy.
Engineered culture substrates have proven invaluable for investigating the role of cell and extracellular matrix geometry in governing cell behavior. While the mechanisms relating geometry to ...phenotype are complex, it is clear that the actin cytoskeleton plays a key role in integrating geometric inputs and transducing these cues into intracellular signals that drive downstream biology. Here, we review recent progress in elucidating the role of the cell and matrix geometry in regulating actin cytoskeletal architecture and mechanics. We address new developments in traditional two-dimensional culture paradigms and discuss efforts to extend these advances to three-dimensional systems, ranging from nanotextured surfaces to microtopographical systems (e.g. channels) to fully three-dimensional matrices.
Tissue-type plasminogen activator (tPA) is a serine protease well known to promote fibrinolysis. This is why: its recombinant form (rtPA) can be used, either alone or combined with thrombectomy, to ...promote recanalization/reperfusion following ischemic stroke. However, its overall benefits are counteracted by some of its side-effects, including incomplete lysis of clots, an increased risk of hemorrhagic transformation and the possibility of neurotoxicity. Nevertheless, better understanding of the mechanisms by which tPA influences brain function and promotes its alteration may help in the design of new strategies to improve stroke therapy.
To update the estimated global incidence of Japanese encephalitis (JE) using recent data for the purpose of guiding prevention and control efforts.
Thirty-two areas endemic for JE in 24 Asian and ...Western Pacific countries were sorted into 10 incidence groups on the basis of published data and expert opinion. Population-based surveillance studies using laboratory-confirmed cases were sought for each incidence group by a computerized search of the scientific literature. When no eligible studies existed for a particular incidence group, incidence data were extrapolated from related groups.
A total of 12 eligible studies representing 7 of 10 incidence groups in 24 JE-endemic countries were identified. Approximately 67,900 JE cases typically occur annually (overall incidence: 1.8 per 100,000), of which only about 10% are reported to the World Health Organization. Approximately 33,900 (50%) of these cases occur in China (excluding Taiwan) and approximately 51,000 (75%) occur in children aged 0-14 years (incidence: 5.4 per 100,000). Approximately 55,000 (81%) cases occur in areas with well established or developing JE vaccination programmes, while approximately 12,900 (19%) occur in areas with minimal or no JE vaccination programmes.
Recent data allowed us to refine the estimate of the global incidence of JE, which remains substantial despite improvements in vaccination coverage. More and better incidence studies in selected countries, particularly China and India, are needed to further refine these estimates.
More than 90% of cervical cancer deaths occur in low- and middle-income countries (LMICs), which have limited capacity to mount the comprehensive national screening and precancer treatment programs ...that could prevent most of these deaths. The development of vaccines against the human papillomavirus (HPV) has dramatically altered the landscape of cervical cancer prevention. As of mid-2020, 56 LMICs (41% of all LMICs) have initiated national HPV vaccination programs. This paper reviews the experience of LMICs that have introduced HPV vaccine into their national programs, key lessons learned, HPV vaccination sustainability and scale-up challenges, and future mitigation measures.
As international guidance evolved and countries accumulated experience, strategies for national introduction shifted with regard to target groups, delivery site and timing, preparation and planning, communications and social mobilization, and ultimately monitoring, supervision and evaluation. Despite the successes that LMICs have been able to achieve in reaching large proportions of eligible girls, there are still considerable challenges countries encounter in overcoming rumors, reaching out-of-school girls, completing the vaccine series, estimating target populations, monitoring program performance, and assuring vaccination sustainability. New opportunities, such as the entry of additional vaccine manufacturers and ongoing studies to evaluate one-dose delivery, could help overcome the outstanding barriers to higher coverage and financial sustainability. Effective use of the experience to date and advances on the horizon could enable all LMICs to move towards the coverage levels that are needed to achieve eventual elimination.
•School-based delivery achieves higher coverage but countries concerned about cost.•Trade-offs between age- and grade-based strategy remains complex, country-specific.•Managing rumors and misinformation is critical to success; preparedness is key.•Good coordination between health and education sectors essential for HPV vaccine.
•Many entrepreneurs start their businesses while staying employed.•The employers’ perceptions and behaviors towards such employees are unexplored.•We identify nine types of outcomes that employers ...associate with such employees.•Experience with enterprising individuals leads to more optimistic expectations.•The effects of outcome expectancies on employer behavior are context-specific.
Many entrepreneurs start their businesses while staying employed. Although such businesses are theorized to have positive and negative effects on employers’ businesses, employers’ perceptions and reactions to subordinates’ entrepreneurial side businesses are mostly unexplored. Based on a vignette study of 988 managers, we find that employers acknowledge both opportunities related to increased job performance and job attitudes as well as threats emerging from enterprising employees. Employers’ prior experiences with enterprising employees make them perceive positive consequences as more likely. Situational factors affect the outcome expectancies and moderate the relationships between these outcome expectancies and employer behavior. We discuss implications of our findings for fostering entrepreneurial mindsets in established organizations and for the emergence of entrepreneurship.
This study examines the relationship between prenatal testosterone exposure (PTE) and selection into entrepreneurship. We argue that the relationship between PTE and entrepreneurial intent is ...positive and mediated by general and domain–specific risk–taking related to financial investment and professional career. Using the second–to–fourth digit ratio (2D:4D) as noninvasive retrospective marker for PTE, we identify two–step mediation effects of PTE on entrepreneurial intent through both general and domain–specific risk–taking. To account for possible socialization–based effects, we control for gender and parental self–employment. Applying ordinary least squares (OLS) regression analyses and structural equation models, we provide empirical evidence for a biological association between 2D:4D and entrepreneurial intent.
•Captive and contract R&D offshoring differently affect firm innovation performance.•The degree of R&D offshoring determines positive or negative impact on firm innovation.•Captive offshoring R&D is ...advantageous at relatively higher degrees of offshoring.•Contract offshoring R&D is most beneficial at lower degrees of offshoring.•For both offshoring strategies, excessive R&D offshoring decreases firm innovation.
Innovating firms may acquire foreign knowledge and improve their innovation performance by offshoring their R&D activities to their own foreign affiliates (captive offshoring) as well as by contracting out their R&D to external foreign parties (contract offshoring). This study examines the impact of both R&D offshoring strategies on innovation performance. Based on a panel dataset of 2421 R&D-active firms in Germany, we demonstrate that captive offshoring and contract offshoring differ fundamentally in their impact on firm innovation performance. At low degrees of offshoring, contract offshoring positively affects innovation performance and is preferable over captive offshoring. At larger degrees of offshoring, captive offshoring becomes more beneficial while contract offshoring is disadvantageous. Both offshoring strategies eventually harm innovation performance when excessively employed. Furthermore, the R&D offshoring-performance relationship is leveraged by R&D intensity, such that firms with a larger knowledge stock benefit stronger from both captive and contract offshoring.
•We investigate the relationship between MNEs investment and divestment decisions.•Subsidiaries compete in the domestic arena (at home) and foreign arena (abroad).•We propose a conceptual framework ...of segmented intersubsidiary competition.•We find that intersubsidiary competition is stronger within than across the arenas.•There is a strong intertemporal relationship between investments and divestments.
This paper examines the interdependencies between MNE investment and divestment decisions. We derive a conceptual framework of “segmented intersubsidiary competition” and hypothesize that the competitive pressure of new investments on existing subsidiaries varies by regional dimension. Based on a database of 3524 French MNEs, we analyse intersubsidiary competition and intertemporal adjustment processes of the investment-divestment relationship between 2002 and 2010. Our empirical findings support the theoretical notion of segmented intersubsidiary competition within MNEs: Foreign investments create competitive pressure for foreign subsidiaries to be divested in subsequent periods, where domestic investments spur divestment at home. Inversely, foreign divestments are more likely to create new investment opportunities in the foreign than in the domestic arena. Our differentiations between investments/divestments in EU countries and in non-EU countries shows that the competitive pressure of new investments on existing subsidiaries is mainly limited to the same region.
Contractile actomyosin bundles are key force-producing and mechanosensing elements in muscle and non-muscle tissues. Whereas the organization of muscle myofibrils and mechanism regulating their ...contractility are relatively well-established, the principles by which myosin-II activity and force-balance are regulated in non-muscle cells have remained elusive. We show that Caldesmon, an important component of smooth muscle and non-muscle cell actomyosin bundles, is an elongated protein that functions as a dynamic cross-linker between myosin-II and tropomyosin-actin filaments. Depletion of Caldesmon results in aberrant lateral movement of myosin-II filaments along actin bundles, leading to irregular myosin distribution within stress fibers. This manifests as defects in stress fiber network organization and contractility, and accompanied problems in cell morphogenesis, migration, invasion, and mechanosensing. These results identify Caldesmon as critical factor that ensures regular myosin-II spacing within non-muscle cell actomyosin bundles, and reveal how stress fiber networks are controlled through dynamic cross-linking of tropomyosin-actin and myosin filaments.
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